Faculty of Medicine
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Item type:Publication, Lymphangiomas of the liver and spleen: rare case presentation(2020); ; Objectives: Lymphatic malformations are benign lesions of vascular origin that show lymphatic differentiation. It is considered the lymphatic equivalent of a hemangiomas of blood vessels. A hepatic lymphangioma is a rare benign neoplasm and is usually associated with lymphangiomas of other viscera. It can occur at any age and most lesions are found inciden- tally. Splenic lymphangiomas are relatively rare benign tumors that correspond to abnormal dilatation of lymphatic chan- nels that can be either congenital or acquired. On imaging, they usually present as lobulated and multiloculated cystic le- sions without solid component or significant enhancement. Here we report a rare case of a hepatic cystic lymphangioma in a 73-year-old man and multiple lymphangiomas (cyst) in spleen. Material and methods: It was discovered on a routine ultrasound examination and the patient had no obvious symptoms. A surgical resection of adenocarcinoma of prostate was performed one year ago. There is no need of hemotherapy after sur- gical treatment. Abdominal ultrasonography and computed tomography (CT) showed “hepatic neoplasm” and multiple cys- tic focal lesions in the spleen. Bone biopsy excluded hematological abnormalities. Laboratory examination with tumor markers and X-chest ray were normal. Screening gastroscopy and colonoscopy was performed, and the patient had reflux esophagitis and pendular polyp in sigmoid colon. After polypectomy of sigmoid polyp, histopathology findings show tubu- lous polyp. After all examinations, spleen biopsy was performed. Results: Histological examination of spleen revealed multiple cystic structures lined with epithelial cells on the inner walls, accompanied by interstitial swelling and necrosis, marked as lymphangiomas. Conclusion: A hepatic lymphangioma can be solitary, cystic or associated with multiple liver lesions and is characterized by cystic dilatation of lymphatic vessels in the hepatic parenchyma. A solitary lymphangioma is unusual. Presentation ranges from asymptomatic incidental finding to a large multicentric, symptomatic mass require surgical intervention. They may occur alone on the spleen or as a part of systemic lymphangiomatosis. In our case patient has been followed up for nearly two years with no worsen and enlarged lesions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CHANGES OF SPLEEN IN WISTAR RATS EXPOSED TO THERAPEUTIC DOSES OF DEXAMETHASONE AND MEDROXYPROGESTERONE ACETATE EVALUATED BY STEREOLOGICAL PARAMETERS(Macedonian Academy of Sciences and Arts, 2015); ; The aim of our investigation was to evaluate the immunosuppressive effect of medroxyprogesterone acetate (MPA) determining the volume densities of the structural components of the spleen. The volume densities of the same structural components of spleen were determined after administration of dexamethasone too, in order to see whether the morphological changes induced by MPA are in the same line with the changes caused by dexamethasone. 60 female Wistar rats were divided into 5 groups. The control group of rats was administered phy siological solution. The remaining, 4 experimental groups were administered: dexamethasone at a therapeutic daily dose of 0.6 mg/kg bw and maximal therapeutic dose of 3 mg/kg bw, and MPA at a therapeutic dose of 30 mg/kg bw and maximal therapeutic dose of 150 mg/kg bw. The drugs were applied intramuscularly for 7 days. Spleen paraffin sections were stained according to the methods: hematoxylin-eosin, Masson and Elastica van-Gieson. Stereological measurements were performed by using the Weibl’s multipurpose test system (M-42). The histological analyses of the structural components of the spleen in rats treated with dexametha sone and MPA have shown reduction of the white pulp and the marginal zone and an apparent decrease of the cellular density of the lymphocyte component of the pulp. The stereological analysis of the spleen showed significant decrease of the splenic pulp volume density and significant increase of the connective tissue volume density. Reducing the presence of splenic pulp was mainly due to the decrease in the volume density of all structural components of the white pulp. Changes were obser ved in all drug treated groups of rats. Our results have shown that the MPA provoked changes suggested atrophy of the spleen lymphoid tissue. Although the atrophic changes of the spleen were significant after the application of both dexamethasone and MPA, the white pulp was significantly more sensitive substrate for dexametha sone than for the MPA