Faculty of Medicine
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Item type:Publication, THE IMPACT OF SUBCLINICAL HYPOTHYROIDISM ON THE LIPID PROFILE IN PERIMENOPAUSAL AND POSTMENOPAUSAL WOMEN(Македонска асоцијација на гинеколози и опстетричари = MACEDONIAN ASSSOCIATION OF GYNECOLOGISTS AND OBSTETRICIANS, 2025); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE CORRELATION BETWEEN HIGH BLOOD PRESSURE AND RISK OF ENDOMETRIAL MALIGNANCY IN POSTMENOPAUSAL WOMEN(Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2022); ; ; Introduction. Postmenopause is a period that starts one year after the last menstruation. Late menopause, after 70 years, is called senile. Aim. To examine the correlation between high blood pressure and the risk of endometrial malignancy in postmenopause. Methods. A prospective clinical study was conducted involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics in Skopje, divided into two groups: control and examined. The control group included 40 postmenopausal patients, hospitalized and operated due to urogenital pathology. The examined group consisted of 80 patients. A detailed history of patients was taken and blood pressure was measured, intervention was taken from both groups, and the material obtained was sent for histopathological analysis to determine eventual malignancy. Results. In our study women with high blood pressure were 15.724 [p=0.010, 95% CI=1.932-27.952] times more likely to have endometrial cancer compared to women with normal blood pressure. Conclusion. In postmenopausal patients, the likelihood of endometrial cancer significantly increases with high blood pressure. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HETEROGENEITY OF ENDOMETRIUM – AN INCREASED RISK FACTOR FOR ENDOMETRIAL MALIGNANCY(Македонско лекарско друштво = Macedonian Medical Association, 2021-03); ; ; Introduction. The normal postmenopausal endometrium should appear thin, homogeneous and echogenic. Endometrial cancer causes the endometrium to thicken, appear heterogeneous, have irregular or poorly defined margins, and show increased color Doppler signals. Aim. To examine the correlation between endometrial echogenicity and the risk of endometrial malignancy in postmenopausal women. Methods. This was a prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics-Skopje, divided into two groups: control and examined. The coнtrol group included 40 postmenopausal patients, hospitalized and operated on due to urogenital pathology. The examined group consisted of 80 patients divided into two subgroups – a group with uterine bleeding and the other one without uterine bleeding. According to the ultrasound verified thickness of the endometrium, the two subgroups were divided according to endometrial thickness into: the first group with endometrial thick ness from 5-8 mm; the second from > 8-11mm and the third group above 11 mm. We made ultrasound examination by measuring the echogenicity of the endometrium in both groups of patients as well as in sub groups, which were also divided into other subgroups according to endometrial thickness. Results. The probability of endometrial malignancy was significantly increased by 4,938 in heterogenous endometrium. Conclusion. There are many examples of intratumor heterogeneity in endometrial malignancy, either at the morphologic or the molecular level. Attention should be paid so as not to miss minor subpopulations of tumor cells with diagnostic and prognostic relevance. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hormonal changes in women with abnormal endometrial bleeding in peri and postmenopause(European Society of Endocrinology, 2022-05); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BONE MARKERS IN PERIMENOPAUSAL AND POSTMENOPAUSAL WOMEN WITH ABNORMAL UTERINE BLEEDING(International Osteoporosis Foundation, 2022-03-24); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CORRELATION BETWEEN ENDOMETRIAL NEOVASCULARIZATION AND RISK OF ENDOMETRIAL MALIGNANCY IN POSTMENOPAUSAL WOMEN(Македонско лекарско друштво = Macedonian medical association, 2020); ; ; Introduction. The period that starts one year after the last menstruation is called menopause and it is divided into early and late menopause. Aim. To examine the correlation between endometrial neovascularization and the risk of endometrial malig-nancy in postmenopausal women. Methods. This is a prospective clinical study invol-ving 120 postmenopausal patients treated at the Univer-sity Clinic for Gynecology and Obstetrics-Skopje, di¬vi-ded into two groups: control and examination. The control group included 40 postmenopausal patients, hospitalized and operated due to urogenital pathology. The examined group consisted of 80 patients divided into two subgroups –the group with uterine bleeding and the other one without uterine bleeding. According to the ultrasound verified thickness of the endomet-rium, the two subgroups were divided according to endometrial thickness into: the first group with endo-metrial thickness from 5-8 mm; the second from >8-11 mm and the third group above 11 mm. We made ul¬tra-sound examination by measuring the resistant index (Ri) of the endometrium in both groups of patients as well as in subgroups, which were also divided into other subgroups according to endometrial thickness. Results. The probability of endometrial malignancy was significantly increased by 0.097 times in postme-no¬pausal patients. Conclusion. Doppler examination of endovascular neo-vas¬cularization (Ri) is a significant predictor of endo-met¬rial malignancy (p<0.05). Women with endometrial Doppler Ri>0.42 were 0.097 [p=0.029, 95% CI=0.012- 0.787] times less likely to have endometrial cancer than women with endometrial Doppler Ri≤0.42.