Faculty of Medicine

Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14

Browse

Settings

Language: search.filters.language.EnglishSubject: search.filters.subject.neoplasm

Search Results

Now showing 1 - 3 of 3
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Sex Differences in Patients With Occult Cancer After Venous Thromboembolism.
    (2018)
    Jara-Palomares L,
    ;
    Otero R,
    ;
    Jiménez D,
    ;
    Praena-Fernández JM,
    ;
    Rivas A,
    In patients with venous thromboembolism (VTE), male sex has been associated with an increased risk of occult cancer. The influence of sex on clinical characteristics, treatment, cancer sites, and outcome has not been thoroughly investigated yet. We used the Registro Informatizado Enfermedad TromboEmbólica registry to compare the clinical characteristics, treatment strategies, cancer sites, and clinical outcomes in patients with VTE having occult cancer, according to sex. As of June 2014, 5864 patients were recruited, of whom 444 (7.6%; 95% confidence interval: 6.8-8.2) had occult cancer. Of these, 246 (55%) were men. Median time elapsed from VTE to occult cancer was 4 months (interquartile range: 2-8.4), with no sex differences. Women were older, weighed less, and were less likely to have chronic lung disease than men. The most common cancer sites were the lung (n = 63), prostate (n = 42), and colorectal (n = 29) in men and colorectal (n = 38), breast (n = 23), uterine (n = 18), hematologic (n = 17), or pancreas (n = 15) in women. Men were more likely to have lung cancer than women (2.18% vs 0.30%; P < .01) and less likely to have pancreatic cancer (0.17% vs 0.5%; P = .03). Interestingly, breast cancer was more likely found in women aged ≥50 years than in those aged <50 years (0.97% vs 0.14%; P = .03). This study highlights the existence of sex differences in patients with VTE having occult cancer. One in every 2 men had lung, prostate, or colorectal cancer. In women, there is a heterogeneity of cancer sites, increasing risk of breast cancer in those aged >50 years.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Development of a Risk Prediction Score for Occult Cancer in Patients With VTE
    (Elsevier, 2016)
    Jara-Palomares L,
    ;
    Otero R,
    ;
    Jimenez D,
    ;
    Carrier M,
    ;
    Tzoran I,
    Background: The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE. Methods: We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period. Results: Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ≤ 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ≥ 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups. Conclusions: This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    The role of immunohistochemistry in lymphoplasmacyte-rich meningioma
    (Macedonian Association of Pathology, 2016-09)
    ;
    ;
    ;
    ;
    Objective: Lymphoplasmacyte-rich meningioma is a very rare subtype of benign meningioma, which is characterized by prominent inflammatory cell infiltration with sparse meningothelial component. The incidence is less than 1% of all meningiomas. We present a case of 45-year-old male without any systemic hematologic abnormalities. Material and Methods: The patient was admitted to the University Clinic of Neurosurgery with headache, confusion, disorientation, nausea and vomiting. Neurological examination and complete blood count were normal. The MRI revealed isodense, contrast-enhanced dural mass in the right frontal parasagital region. Total tumorectomy was done and gross examination showed oval, well-circumsribed tumor with diameter of 4 cm. Results: Microscopic analysis showed neoplasm composed of rare nests of meningothelial cells surrounded by extensive lymphocytic and plasma cell infiltrate, separated by proliferated collagenous connective tissue bands. The meningothelial cells had round to oval nuclei without clear cytoplasmic borders. Immunohistochemistry showed positive signal for EMA, PR, CD3, CD4, CD20, LCA, CD79alfa, and Bcl2; focal positive signal for CD138, IgA, IgD, IgG, IgM, kappa, lambda and negative signal for CD34, CD10,CD23. The proliferative index for Ki-67 was low (4%). Conclusions: Immunohistochemical analysis had a crucial diagnostic role in differentiating this rare tumor subtype from intracranial inflammatory process.