DSpace-CRIS

Now showing 1 - 3 of 3

Some of the metrics are blocked by your
consent settings
Malignant transformation and tumour recurrence in sacrococcygeal teratoma: a global, retrospective cohort study
(Wolters Kluwer, 2024-11)
van Heurn, Lieke J
;
Derikx, Joep
;
Hall, Nigel
;
Aldrink, Jennifer H.
;
Bailez, Maria M.
Introduction: Sacrococcygeal teratoma (SCT) is a rare congenital tumour. The risk of malignancy and recurrence is not well defined. Previous studies are small and report differing conclusions about the timing of surgery and the duration of follow-up. The authors studied the risk of malignant transformation and SCT recurrence after surgery to address these gaps. Methods: This was a global retrospective cohort study. Data of consecutive SCT patients was obtained from 145 institutes in 62 countries. Malignant transformation, defined as malignancy at initial resection, malignant recurrence or death due to malignancy, and its risk factors were analysed. Results: Of the 3612 included patients, 3407 entered analysis. The risk of malignant transformation of the initial tumour was 3.3, 5.1, 10.1, and 32.9% at age 3 months, 6 months, 1 year, and 2 years, respectively. After 6 years, the censored risk of malignancy (64%) did not further increase. Recurrent SCT was diagnosed in 349 (10.2%) children with 126 (36.1%) malignant recurrences. Risk factors for recurrence were Altman type II [odds ratio (OR): 1.6, 95% confidence interval (CI): 1.2–2.2], Altman type III (OR: 1.6, 95% CI: 1.2–2.3), initial immature histology (OR: 1.9, 95% CI: 1.4–2.6), and initial malignant histology (OR: 4.0, 95% CI: 2.9–5.4). Conclusion: The risk of malignancy at initial resection in SCT increases with age reaching a plateau at 6 years of age. Recurrence after resection occurred in 10% of patients and 36% of these were malignant at that time. Altman type II or type III, and immature or malignant histology were associated with recurrence.
Some of the metrics are blocked by your
consent settings
CORRELATION BETWEEN HISTOLOGICAL FINDINGS AND CYTOLOGICAL FINDINGS AND HPV STATUS IN PATIENTS WITH HSIL - RETROSPECTIVE STUDY
(Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2025-01-01)
Stanojevic, Verdi
;
;
;
;
Mircevska, Megi
Introduction. Cervical intraepithelial neoplasia (CIN) and invasive cervical cancer are most commonly caused by human papillomavirus, which causes malig¬nant transformation of cervical epithelial cells. The aim of this study was to investigate the association between different HPV types and histological changes of the cervix in patients in our hospital. Methods. In the period from January 2022 to Decem¬ber 2023, an analysis of 100 samples was made with histological findings confirmed by biopsy from the University Clinic for Gynecology and Obstetrics in Skopje. The relationship between HRHPV and high-grade CIN and CIS, as well as the age-dependent prevalence of single HPV infection, were examined. Results. In both CIN2, CIN3 and CIS group, HPV16, 18, 31, 33 and 58 were detected as the top 5 high-risk human papillomavirus (hrHPV) types. HPV16 was the predominant genotype in CIN2, CIN3 and CIS, with 44.23%, 60.53% and 90% respectively. The prevalence of HPV16 was most common in all age groups. The peak incidence of CIN2 was observed from 31-40 and 41-50 years (28.85%), and CIN3 from 21-30 (28.95) and 51-60 years (23.68), and CIS from 31-40 (40%) and 41-50 years of age (30%). Conclusion. If circumstances permit, women between the ages of 21 and 60 are advised to undergo norma¬tive screening for high-grade CIN. Patients who test positive for HPV16 should be prioritised for opportu¬nistic screening. Patients infected with other forms of HPV should also be treated seriously if they are ladies 61 years of age or older. The most prevalent genotypes in our patients were HPV16, 18, 31, 33 and 58. Therefore, a vaccine including these dominant genotypes may be crucial for preventing cervical cancer.
Some of the metrics are blocked by your
consent settings
Malignant diffuse peritoneal leiomyomatosis: A case report
(Expansion Scientifique Publications, 1998-10)
;
Ivkovski, Ljube
;
Yashar, Genghis
;
Veljanovska, Slavica
;
Vuzevski, Vojislav
Diffuse peritoneal leiomyomatosis (DPL) is a rare condition characterized by the presence of multiple abdominal smooth muscle nodules. Malignant transformation appears to be extremely rare. This report presents the eighth case with proven malignancy. The patient is a 43 year old, Caucasian, non-pregnant female, with no history of hormonal therapy, presented with a few months old history of intermittent and increasing right lower abdominal pain. In October 1996, explorative laparatomy was performed. Innumerable subperitoneal gray-white masses with firm to rubbery consistency, varying in size from 0.2 to 11.5 cm, were found scattered over the parietal peritoneum, omentum and mesentery. Several of these nodules were removed. Their microscopic appearance was variable. Most of the lesions appeared to consist of subperitonel nodules of benign-appearing smooth muscle cells. Nevertheless, some of them showed malignant characteristics, marked cellularity, and numerous mitoses. Immunohistochemical and ultrastuctural studies proved the smooth muscle origin of the tumors. During the next few months the abdominal tumors increased in size and the patient's condition progressively deteriorated. A second laparotomy was performed in March 1997. More than 40 nodules were removed together with a small bowel segment where inflammatory fistula was found. After receiving three courses of chemotherapy, the patient refused further treatment. In December 1997, the patient was admitted to the hospital with acute abdominal pain due to ileus, and the third laparotomy was performed. This additional case indicates that DPL has a low, but definite malignant potential, and suggests that meticulous examination of histologic material and careful follow up are required.

Faculty of Medicine

Browse

Filters

Settings

Sort By

Results per page

Search Results