Faculty of Medicine

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    Rare concomitant myxoid and cystic degeneration of uterine leiomyoma: Case report
    (Centre for Evaluation in Education and Science (CEON/CEES), 2021)
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    Paneva, Iva
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    The uterine leiomyomas are monoclonal tumours of myometrial smooth muscle cells that are oestrogen dependent. A 43-year-old patient was referred by her gynaecologist under a suspected diagnosis of ovarian tumour. She complained of prolonged and profuse, regular menstrual bleeding that leaded to anaemia. The ultrasound examination showed a complex tumour mass with dimensions 68 x 85 mm, with several cystic formations fulfilled with clear fluid, which protrudes from the posterior wall of the uterus. Therefore, the diagnosis of leiomyoma with a cystic degeneration was considered preoperatively. In the case of cystic degeneration of the myoma, the ultrasound shows a combination of cystic and solid components with irregular shape and variable echogenicity. The ovarian malignancy should be ruled out in the presence of a large cystic mass with irregular septa and solid nodular parts filling the small pelvis. Ultrasound characteristics of degenerative myomas should always be considered, so as not to replace it with an ovarian mass, especially if it is subserosal and on the loop.
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    Common blue nevus of the uterine cervix - A report of 16 cases
    (Macedonian Association of Anatomists and Morphologists, 2005)
    Kubelka-Sabit, Katerina
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    Hadzi-Nicheva, Biljana
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    Grncharovska, Zlata
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    Prodanova, Irina
    Blue nevus is uncommon pigmented lesion of the skin that rarely appears in the different mucoses, such as cervix or vagina. Sixteen cases of cervical blue nevi were diagnosed in our department in a five-year period (2000-2004). Localized in the stroma of the cervical canal, predominantly in the posterior lip, the lesions measured 0.1-2 cm. Prussian blue stain excluded the presence of hemosiderin and Masson-Fontana, S100 and HMB-45 stains confirmed the melanocytic nature of the lesions. Our findings are similar to those published in several studies. The recognition of this obscure lesion prevents its misinterpretation as siderosis or malignant melanoma.
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    Recurrent aggressive angiomyxoma of the vulva. A case report
    (Macedonian Association of Anatomists and Morphologists, 2007)
    Kubelka-Sabit, Katerina
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    Prodanova, Irina
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    Zografski, George
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    Intraduction: Aggressive angiomyxoma is a rare, benign, slow-growing, locally aggressive tumor, occurring in women in their reproductive years. Case report: A case of aggressive angiomyxoma of the vulva, clinically interpreted as a cyst, occurring in a 32-year-old female patient is presented. After incomplete removal, the tumor recurred more than ten times in the next 28 years. During the initial histopathological examination of the recurrent tumors they were misinterpreted as dermatofibroma/dermatofibrosarcoma. Differential diagnostic and therapeutical possibilities are discussed as well. Conclusion: The risk of recurrence in patients with aggressive angiomyxoma can be significantly reduced with appropriate recognition and adequate therapy.