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Etiology, epidemiology, clinical implications and treatment of acute bronchiolitis-a review of the literature
(Macedonian Association of Anatomists and Morphologists, 2013)
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Petrushevska-Kolekevska, Lidija
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Dilberovska, Mirjana
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Popova, Gorica
;
Stevic, Valentina
Bronchiolitis is an acute viral infection that is one of the leading causes for hospitalization in young children. Despite the fact that etiology and clinical sings of the disease are well-known, in this article we will give summary of the latest scientific data related to the bronchiolitis. Bronchiolitis still remains an active field for research with many open questions still remains to be answered – ista recenica. Majority of bronchiolitis episodes are caused by respiratory syncytial virus and most often occur in children aged between two and 24 months. Most children get better with supportive care at home. A small number of children require hospitalization and treatment with oxygen and hydration.
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SOME ASPECTS OF COVID-19 TREATMENT -CURRENT RECOMMENDATIONS AND OUR OBSERVATIONS
(Македонско лекарско друштво = Macedonian Medical Association, 2021-01)
Treatment of COVID-19 is currently a global challen-ge. Since the beginning of the infection, owing to awell-planned and organized research, knowledge in itstreatment has been gained and recommendations havebeen made. These recommendations are flexible andsubject to changes depending on the results obtained inthe latest investigations. There is no officially acceptedprotocol for treatment of patients with COVID-19 inthe Republic of North Macedonia. This has resulted invery diverse therapeutic regimens mainly based on in-dividual experience and intuition and without sufficientconsistency with the globally recommended therapeuticprinciples. By conducting a survey-questionnaire amongdoctors who are working in COVID-19 centers in ourcountry, the aim of this paper was to verify this sta-tement and to offer a solution for uniform approach totreatment of COVID-19 based on the recommendda-tions of renowned world health institutions. Each ques-tionnaire distributed among those involved in treatmentof COVID-19 contained 10 questions. A total of 194questionnaires were filled-in anonymously on a volun-tary basis, and of 1940 possible answers 851 (44%) werecorrect. To 6 of the 10 questions, the largest number ofsurveyed respondents has chosen the correct answer.The incorrect answers among the offered ones were ina range of 0 to 74%. The survey-questionnaire has showndistinct variations in the received answers, which infact reflects the divergent attitudes to treatment ofCOVID-19. Therefore, it is indispensable to have astandardized approach to management of patients withCOVID-19, supported by an organized and stimulatededucation of the involved health care workers.
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PREVENTION OF BONE MINERAL LOSS IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES
(Македонско лекарско друштво = Macedonian Medical Association, 2020)
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Filip Guchev
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Mimoza Nicolovska-Kotevska
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Dubravka Antova
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Introduction. Corticosteroids are therapeutic support for many medical conditions including systemic inflammatory rheumatic diseases. Secondary osteoporosis is one of the major complications from this therapy. Bisphosphonates are indicated for prevention and treatment of corticosteroid-induced osteoporosis. Aim. In a retrospective cross-sectional study to assess the effect of the early use of bisphosphonates on bone mineral density in patients with inflammatory rheumatic diseases treated with corticosteroids. Methods. We compared bone mineral density in an examined group of 75 posmenopausal women with inflammatory rheumatic diseases on a corticosteroid therapy who were treated early with bisphosphonates, with a control group of 80 postmenopausal women with osteoarthritis who have never been treated with corticosteroids. Bone mineral density was measured at the lumbar spine and left femur using Dual X-Ray absorptimetry in both groups of subjects. Results. Patients with inflammatory rheumatic diseases had an average T-score at the lumbar spine of -2.19, and -1.41 at the left hip. The average T-score for the control group was -2.24 at the lumbar spine and -1.53 at the hip. Difference in T-score at the lumbar spine and the left hip between the two groups was 0.073 and 0.300 (P=0.639 and P=0.048), respectively. There was no statistically significant difference in the T-scores for both groups. Conclusion. Osteoporosis is more prevalent in patients with inlammatory rheumatic diseases, both at the hips and the spine. The early use of bisphosphonates in patients with inflammatory rheumatic diseases, especially in those who are on corticosteroids, can prevent the loss of bone mineral density

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