Faculty of Medicine
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Item type:Publication, Corrosive poisonings during the COVID-19 pandemic: trends and demographic shifts in the pre- and early vaccination periods (2020–2021)(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2025-09-15); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute poisonings from the perspective of a family doctor(2023-05)Acute poisonings with chemicals, plants and venoms are emergency medical problems, with medication ingestions as the most common and corrosive poisonings as severe dramatic conditions. The family doctor is often the patient’s first choice for medical consultation. The objective of this study is to present the evidence-based consensus guidelines that the family doctor can use as first line treatment and advice. Common poisonings are drug poisonings, mostly with benzodiazepines, antidepressants, antipsychotics, antiepileptics and others. Anamnesis according to a recommended list of questions can point to the probable severity of poisoning and the treatment emergency. The initial treatment for medication poisoning is the use of medical charcoal. The greatest efficiency is achieved if it is ingested during the first hour postingestion. Recommended doses are 1 g/kg or 25-100 gr, usually 50 g at once. Benzodiazepines induce sedative-hypnotic toxidrome that includes central nervous system (CNS) depression with normal or near-normal vital signs. The dose required to produce respiratory compromise is difficult to quantify. Toxicity depends on multiple factors, including dosage, tolerance, weight, age, coingestants and even genetics. Concomitant ingestion of other CNS depressants (alcohol, antipsychotics, opioids) may result in a more severe CNS depression and life-threatening condition. Corrosive poisoning is always a medical condition which should have in-hospital assessment. In case of the initial consultation with the family doctor, they should be advised not to perform self-lavage and not to take medical charcoal which further complicates the endoscopic evaluation of the severity of the poisoning and thus the appropriateness of the treatment. Conclusion: Acute poisonings are urgent, sometimes life-threatening conditions. Advised treatment from the general practitioner in the first hour of poisoning improves the clinical course and prognosis of poisoning. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE TREND OF CORROSIVE POISONINGS IN NORTH MACEDONIA – IS THERE A CHANGE IN THE PATTERN OF CORROSIVE POISONINGS?(2023-05); ; ; Corrosive poisonings (CP) has remained highly presented in developing countries as opposite to the developed ones where they are declining. Objective was comparing the epidemiological characteristics of CP in the last two years to the predicted values (PV) calculated according previous 10 year-period trend analysis. There were 1668 acute CP from 2010 to 2021. CP decreased during the last 12 years period (y=-6.5+181.4, R2=0.56), increased by 1.5% during 2020 due to COVID-19 curfews, and decreased by 25.5% in 2021, compared to PV. Females increased during 2020 by 7.7% and then continued to decrease during 2021 by 27.5%, while males declined during 2020 and 2021 by 16.6% and 32.4% respectively, compared to PV, becoming almost equally represented in 2021. During 2020 and 2021 CP increased in adolescents (by 12.8% and 80.0%) and older than 75 years (by 2.5% and 6.2%), but not in adults who rose during 2020 by 3.7% and declined in 2021 by 17.9% compared to PV. The suicidal CP presented in proportion slightly rose (y=0.01x+0.56, R2= 0.07) during 12 years period, decreased in 2020 by 4.6% and increased by 9.9% in 2021 compared to PV. The CP declined during the last 12 years in North Macedonia with an increase in suicidal CP and more significant reduction in females compared to males. The age group patterns changed by increasing poisonings in adolescent and older the 75 years during the last two years, becoming target vulnerable groups that require increased medico-social attention.