Faculty of Medicine
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Item type:Publication, BACTERIAL MORPHOTYPES OF BACTERIAL VAGINOSIS(Institute of Knowledge Management, 2022-02); Bacterial vaginosis is a disorder in the composition of the vaginal flora that leads to a decrease in the number of hydrogen peroxide-producing lactobacilli and a predominance of various anaerobic bacteria. A retrospective cohort study, performed on a series of 192 patients aged 20 to 59 years, divided into two groups: examined and control. The study group included 128 sexually active women with a Pap smear that showed the presence of a squamous intraepithelial lesion or squamous invasive cervical cancer. The control group included 64 sexually active women with a normal PAP smear. All women have a Nugent score system. The most common bacterial morphotype of bacterial vaginosis in women in the study group was Gardnerella vaginalis (96.43%; 54/56), followed by descending order: Bacteroides species (69.64%; 39/56), Mobiluncus species (51,78%; 29/56), Prevotella species (50.00; 28/56) and Lactobacillus species (19.64%; 11/56). The most common bacterial morphotype detected in patients with normal cervical cytology was Lactobacillus species (96.87%; 62/64), followed by descending order: Gardnerella vaginalis (28.12%; 18/64), Bacteroides species (23.44%; 15/64) and Mobiluncus species and Prevotella species (with 9.37% each; 6/64). Bacterial vaginosis was detected in 43.75% of patients with squamous cell abnormalities of the cervix and in 12.50% of patients with normal cervical cytology. Data analysis showed: correlation between the presence of bacterial vaginosis and the occurrence of squamous cell abnormalities of the cervix (chi-square test = 4.19, p <0.05); increase in the presence of bacterial vaginosis in parallel with an increase in the cytopathological degree of cervical lesion (chi-square test = 12.19, p˂0.05) and that bacterial vaginosis was most common in patients under 30 years of age (57, 14%; 16/28). Our study showed that Gardnerella vaginalis is the most common bacterial morphotype of bacterial vaginosis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association Between Bacterial Vaginosis and Squamous Intraepithelial Lesions of the Uterine Cervix(Македонско лекарско друштво = Macedonian medical association, 2016-01-01); ; ; ; Introduction. Bacterial vaginosis is polymicrobial, primarily anaerobic infection, previously called non-specific vaginitis or vaginitis accompanied by Gardne-rella vaginallis. It is a result of an imbalance between different types of bacteria in the vagina. The aim of the study was to determine the association between bacterial vaginosis and squamous intraepithelial lesions of the uterine cervix. Methods. This cross-sectional study was conducted in a series of 338 sexually active women with cytologicallly diagnosed squamous intraepithelial lesion of the uterine cervix at the University Clinic of Gynecology and Obstetrics in Skopje in the period from October 2014 to October 2015. The age of the patients ranged from 20 to 59 years (35±10.49). All women underwent cervical biopsy with endocervical curettage for histopathological analysis and cervical biopsy for detection and HPV typing. Criteria for diagnosis of bacterial vaginosis was the presence of ≥20% clue cells of ePapanicolaou smear. Results. Bacterial vaginosis was detected in 19.5% (66/338) of the examined women. The most affected was the young population under the age of 30 years. The results showed an association between bacterial vaginosis and squamous intraepithelial lesions of the uterine cervix (p=0.032). There was no association between bacterial vaginosis and the grade of lesion of the uterine cervix (p=0.118), nor with HPV infection (p=0.570). But, however an association was found between HPV infection and squamous intraepithelial lesions of the uterine cervix (p=0.001). Conclusion.The most common risk factor for squamous intraepithelial lesions of the uterine cervix are persistent high-risk HPV infections. Bacterial vaginosis is the most common co-infection. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE PREVALENCE OF BACTERIAL VAGINOSIS IN PATIENTS WITH CERVICAL DYSPLASIA(Udruženje ginekologa i perinatologa Tuzlanskog kantona, 2022-05); ; Aleksandra Eftimova