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THE ROLE AND IMPORTANCE OF THE SCREENING PROGRAM IN DETECTING INVASIVE BREAST CARCINOMA OF NONSPECIFIC TYPE IN WOMEN WITHOUT PREVIOUS DIAGNOSTIC PROCEDURES FOR BREAST CANCER
(Македонско лекарско друштво = Macedonian medical association, 2025-04)
Angelovska, Makedonka
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Damcheska, Jasminka
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Trajchevska, Irena
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Gjorcheva Kamcheva, Gordana
A case presentation of a 66-year-old woman who was invited for a mammographic examination through the Screening Program for Early Detection of Breast Cancer. Previously, the woman had not undergone regular mammographic screenings. A mammogram was performed, and a spiculated dense mass of 2 cm was found in the upper lateral quadrant of the right breast, involving the surrounding parenchyma, highly suspicious for malignancy. A core biopsy was performed on the hypoechoic lesion of 2 cm in the upper outer quadrant of the right breast, guided by ultrasound. Three cylinders were taken, which were sent for pathohistological evaluation. The result from the pathohistological evaluation corresponds to invasive breast carcinoma of a nonspecific type.
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Breast Hamartoma with Coexistent DCIS: Radiological Challenges
(2024-04)
Lazareva, Zora
;
This article explores the diagnostic complexity of a 53-year-old woman with palpable breast abnormalities, uncovering a dual narrative of hamartoma and coexisting ductal carcinoma in situ (DCIS). Radiological insights into these lesions highlight the challenges in accurate diagnosis. Introduction: Breast hamartomas, presenting as a "breast within a breast" on mammograms, pose diagnostic challenges. In this case, a unique scenario emerges as a breast hamartoma coexists with cancer, emphasizing the complexity faced by radiologists in such diagnostic journeys. A 53-year-old woman with palpable breast abnormalities undergoes mammography, revealing a well-circumscribed mass with a "breast within a breast" appearance, characteristic of a hamartoma. However, suspicious features of malignant microcalcification within the hamartoma suggest coexisting cancer, showcasing the intricate interplay of benign and malignant elements. Ultrasound struggles to delineate the lesion's margins due to its normal breast tissue resemblance. Mammography displays the classic "breast in breast" appearance of the hamartoma, with additional features of microcalcification raising concerns of malignancy. Integrating imaging findings with pathology is crucial in discerning the complex interplay between benign and malignant elements. The diagnostic landscape reveals a breast hamartoma on the left side, intricately intertwined with cancerous components, highlighting the challenges in discerning dual pathology within breast lesions. This case illuminates the diagnostic intricacies associated with breast lesions, showcasing the coexistence of a benign hamartoma and cancerous elements. Accurate diagnosis demands a nuanced understanding of imaging findings and collaborative efforts between radiologists and pathologists. The diagnostic journey underscores the complexity of breast lesions, where a hamartoma conceals malignant elements. Advanced imaging is crucial for navigating this intricacy, and multidisciplinary collaboration is paramount for accurate diagnosis and tailored management. Keywords: Breast hamartoma, Ductal carcinoma in situ (DCIS), Mammography.
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The role of pre- operative wire localisation of occult lesions for early detection of breast cancer.
(2012-03)
An increasing number of non-palpable breast lesions are being detected due to the widespread use of screening mammography in asymptomatic women. The sensitivity of the first screening mammogram increases with age. The ability of mammography to differentiate malignant lesions from benign ones is quite variable, where 9%–63% of all reported mammographic abnormalities are eventually diagnosed as malignant. Needle localisation open breast biopsy was first introduced in 1965 in order to obtain a histological diagnosis of such lesions. The placement of the radio-opaque wire percutaneously into the lesion, under the guidance of either a mammogram or an ultrasonography, is done preoperatively by the radiologist. The rationale for this is that the wire guides the surgeon to the exact site of the lesion and hence avoids the removal of an unnecessarily large volume of breast tissue. In this audit, we examined our institution’s experience with performing hookwire localisation biopsy for mammogram-detected lesions that were classified as suspicious breast lesions such as non-palpable breast mass or clustered microcalcifications, that require accurate diagnosis to achieve early detection of cancer. Complete removal of the lesion associated with radiological study of the specimen appears to be critical to avoid false negative findings and to provide precise histopathologic diagnosis. The aim of the study was to evaluate our experience with an original method of wire localisation followed by excisional biopsy for occult breast lesions and to proove the usefulness of preoperative hooked-wire localization of such lesions for the early detection of breast cancer.

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