Faculty of Medicine

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Language: search.filters.language.EnglishSubject: search.filters.subject.Allergic Sensitization

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    Respiratory and Nasal Symptoms, Immunological Changes, and Lung Function in Industrial Bakers
    (ID Design 2012/DOOEL Skopje, 2012-03-01)
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    Background: Several studies reported that occupational exposure in bakery may cause respiratory impairment in exposed workers. Aim: To assess the respiratory effects and immunological changes of occupational exposure in industrial bakers. Material and Methods: We performed a cross-sectional study including 43 industrial bakers (20 males and 23 females, aged 34-55 years) and an equal number of office workers, matched by sex, age and smoking status. Evaluation of examined subjects included completion of questionnaire, skin prick tests to common and work-related inhalant allergens, spirometry, and histamine challenge. Results: We found higher prevalence of nasal symptoms in the last 12 months in bakers with significant difference for runny nose (P = 0.033). Prevalence of respiratory symptoms in the last 12 months was also higher in bakers and statistical significance was obtained for cough (P = 0.041) and phlegm (P = 0.023). We found similar prevalence of allergic sensitization to common inhalant allergens in both examined groups, while sensitization to wheat flour and meal flour was registered only among bakers. Measured spirometric parameters were lower in bakers with significant difference for MEF50 and MEF75 (P = 0.004, and P = 0.000, respectively). Prevalence of bronchial hyperresponsiveness (BHR) was non-significantly higher in bakers with significantly higher severity (P = 0.029). Conclusion: Our findings confirm that occupational exposure in industrial bakers may lead to adverse respiratory effects and immunological changes in exposed workers.
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    Prevalence of the Respiratory Allergies among Adult Population in the City of Skopje in Relation to Climatic Change and Change in Pollen Micro Flora
    (Scientific Research Publishing, Inc., 2012)
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    Kendrovski, Vladimir
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    Milkovska, Snezana
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    Introduction: Climate change may have an impact of prevalence and severity of respiratory allergies causing changes in the concentrations, distribution, dispersion patterns, and allergenic potential of aeroallergens in the environment. Objective: To assess the prevalence of atopy, sensitization to common pollen allergens, and respiratory allergies (aller-gic rhinitis and asthma) among adult population in the city of Skopje in relation to changes in pollen distributions caused by climate change and particularly maximum temperature, in the period 1996-2010. Methods: Aeropalinologi-cal measurements in the city of Skopje were performed by volumetric method in the period 1996-2009. Serial cross-sectional studies on the prevalence of atopy, sensitization to common pollen allergens, allergic rhinitis and asthma in adults by standardized methodology were conducted in defined critical periods (1996, 2003, 2007/2008 and 2009/2010). Evaluation of examined subjects included completion of a questionnaire, skin prick tests (SPT) to common inhalant allergens, and lung function tests. Results: Data from aeropalinological measurements showed differences in the pollen concentrations, as well as in the duration of pollen season for some pollen types. The prevalence of atopics was similar in all critical periods, and the prevalence of sensitization to common pollen allergens was slightly higher in the last study than in the study performed in 1996. We registered increase in the prevalence of allergic rhinitis in the examined period (11.5% in 1996 to 17.4% in 2009/2010) followed by increase in the prevalence of rhinitics sensitized to common pollen allergens. The prevalence of allergic asthma was significantly higher in the study conducted in 2009/2010 than in the study conducted in 1996 (5.1% vs. 2.1%, P = 0.037) followed by slightly higher prevalence of asthmatics sensitized to common pollen allergens in the same period. Conclusions: Registered changes in the preva-lence of sensitization to common pollen allergens, as well as in the prevalence of subjects with respiratory allergies sen-sitized to these allergens, even statistically non-significant, indicate the need of further monitoring and investigation in order to assess the association between climate change with change in pollen micro flora and related allergic disorders.