Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
64 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, INTEGRATED NON-INVASIVE VASCULAR PHENOTYPING USING ANKLE-BRACHIAL INDEX (ABI) AND PULSE WAVE VELOCITY (PWV) FOR EARLY DETECTION OF SUBCLINICAL ATHEROSCLEROSIS. BRIDGING EVIDENCE FROM COMPREHENSIVE LITERATURE REVIEW AND CASE-BASED CLINICAL EVALUATION(State University of Tetova, 2026-05-20) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, GALACTOMANNAN ANTIGEN TEST IN RESPIRATORY SAMPLES FOR ASPERGILLOSIS DIAGNOSIS(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2025-12-14)Introduction: Invasive aspergillosis is an important cause of mortality in patients with malignant diseases, and is an underestimated infection in critically ill patients. Early diagnosis is still challenging, therefore a rapid and more sensitive diagnostic methods could be beneficial. Aim: the aim of the study was to evaluate the sensitivity and specificity of the galactomannan antigen test in respiratory samples, compared to conventional methods, for early diagnosis of aspergillosis. Material and methods: Samples of 125 patients divided into 4 groups, classified according to diagnosis and EORTC/MSG criteria, were analysed at the Institute of Microbiology and Parasitology, with culture and galactomannan test in respiratory samples, during a period of two years. Results: A total of 71 isolates of Aspergillus were confirmed in this study. Culture of respiratory samples revealed Aspergillus in the group of chronic aspergillosis (63.33%), followed by groups of cystic fibrosis (56.67%), primary immune deficiency (51.43%), and the group with prolonged ICU stay (43.33%). Sensitivity and specificity of respiratory samples’ culture were: 64.29% and 100%, 59.09% and 100%, 54.55% and 12.5%, 100% and 54.17%, in all four groups, respectively. Sensitivity and specificity of galactomannan in respiratory samples, were: 75% and 57.14%, 86.36% and 62.5%, 81.82% and 0%, 50% and 70.83%, in all 4 groups, respectively. Conclusion: The results of this study demonstrate that positive galactomannan test in respiratory samples could be a useful diagnostic adjunct in diagnosis of aspergillosis, along with results from conventional mycological analyses, so timely antifungal treatment is administered. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Mycological profile of dermatomycoses in Macedonian patients(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2025-05) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Emerging opportunistic yeast infections – literature review(Institute of public health of Republic of Macedonia, 2025-12-30)The growing threat of fungal infections demands immediate attention from healthcare systems in all countries. With the advancement of modern medicine and a growing population of immunosuppressed and immunocompromised patients, as well as critically ill patients, increasingly frequent diagnoses of invasive yeast infections have become an important cause of morbidity and mortality. In the last decade, increased incidence of non-albicans Candida species infection compared to C. albicans has been registered worldwide. Several non-albicans Candida species, such as C. glabrata and C. krusei, may be resistant to azole antifungal therapy The emergence of multidrug-resistant C. auris is the latest threat in many countries, since this fungus can cause intrahospital infections. Trichosporon species are the second most common cause of invasive yeast infections in patients with haematological malignancies, and can be resistant to amphotericin and echinocandins. Despite diagnostic and therapeutic advances, cryptococcosis continues to be a disease with unacceptably high incidence and mortality, particularly in resource-limited settings. Rhodotorula species can be a significant cause of catheter-related fungaemia, sepsis, and invasive disease in severely immunosuppressed patients. Other uncommon yeasts that can cause invasive disease in severely immunosuppressed patients include Magnusiomyces capitatus, Geotrichum candidum, Kodamaea ohmeri, Saccharomyces cerevisiae, Malassezia furfur and Sporobolomyces species. Although rare yeasts are emerging as opportunistic human pathogens, diagnosis remains challenging and treatment suboptimal. Therefore, enhanced awareness of fungal infections is crucial among healthcare providers, and this requires great knowledge and understanding, and appropriate diagnostic testing, so every segment of the healthcare system can contribute to address the challenges posed by fungal infections. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EVALUATION OF (1,3)-B-D-GLUCAN ASSAY IN RESPIRATORY SAMPLES FOR DIAGNOSIS OF ASPERGILLOSIS(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-12-16)Introduction: Aspergillosis is significant problem in immunocompromised and critically ill patients. Early diagnosis is still challenging, and therefore there is a need for rapid and more sensitive diagnostic methods. Aim: the aim was to evaluate the performance, sensitivity and specificity of the panfungal (1,3)-b-D-glucan marker in respiratory samples, compared to conventional method, for early diagnosis of aspergillosis. Material and methods: Samples of 125 patients divided into 4 groups, classified according to clinical diagnosis and EORTC/MSG criteria, were analysed at the Institute of Microbiology and Parasitology, with conventional methods and (1,3)-b-D-glucan marker in respiratory samples, during a period of two years. Results: A total of 71 isolates of Aspergillus were confirmed in this study. Four isolates originated from bloodcultures. Culture of respiratory samples revealed Aspergillus in the group of chronic aspergillosis (63.33%), followed by groups of cystic fibrosis (56.67%), primary immune deficiency (51.43%), and the group with prolonged ICU stay (43.33%). Sensitivity and specificity of respiratory samples’ culture were: 64.29% and 100%, 59.09% and 100%, 54.55% and 12.5%, 100% and 54.17%, in all four groups, respectively. Sensitivity and specificity of panfungal (1,3)-b-D-glucan marker in respiratory samples, were: 71.43% and 85.71%, 72.73% and 62.5%, 68.18% and 0%, 50% and 50%, in all 4 groups, respectively. Conclusion: Results of this study demonstrate that a positive (1,3)-b-D-glucan marker in respiratory samples highlights the value of this test as a diagnostic adjunct in diagnosis of aspergillosis, along with results from conventional mycological analyses, so timely antifungal treatment with a favorable clinical outcome, is achieved. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ALMOST PHYSIOLOGICAL CONDUCTIVE DISEASE TREATMENT IN ADVANCED VALVULAR HEART DISEASE(MIT University, 2022) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, KОUNIS SYNDROME - A CASE REPORT OF ACUTE MYOCARDIAL INFARCTION AFTER BEE BITE(MIT University, 2024); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ACUTE MYOCARDIAL INFARCTION AS A PRIMARY MANIFESTATION IN AN ANTREATED TYPE 2 DIABETES MELLITUS PATIENT – CASE REPORT(MIT University, 2026); ; ; Adhurim Fazliu - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CONSERVATIVE TREATMENT OF A CHRONIC WOUND WITH HYDROFIBER DRESSINGS: A CASE REPORT(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2026-06-19); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MULTIPLI VENTRICULAR SEPTAL DEFECTS – A CASE REPORT(MIT University, 2025); ;