Faculty of Medicine
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Item type:Publication, Headache and Covid-19: Experience from the Covid-Centre at the University Clinic of Neurology in Skopje(2021); ; ; ;popovski, neronfilipovikj, dejan - Some of the metrics are blocked by yourconsent settings
Item type:Publication, POSTERIOR SEGMENTAL INSTRUMENTATION AND FUSION WITH HIGH DENSITY ALL POLYAXIAL PEDICLE SCREW CONSTRUCT IN THE TREATMENT OF ADOLESCENT IDIOPATHIC SCOLIOSIS – SINGLE CENTER STUDY(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University in Skopje, R.N.Macedonia, 2021) ;Popovski, Neron; ;Gavrilovski, A ;Shabani, I - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Iatrogenic complication of colorectal surgery: bilateral lesion of the ureters with consequent obstructive nephropathy(Македонско лекарско друштво = Macedonian medical association, 2014) ;Jakimovska, Zorica ;Tutureska, Maja; ; Masin-Spasovska, Jelka - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Evaluation of Neonatal Screening Programs for Tyrosinemia Type 1 Worldwide(MDPI AG, 2024-12-16) ;Kuypers, Allysa ;Bouva, Marelle ;Loeber, J. ;Boelen, AnitaDekkers, Eugenie - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MECONIUM ILEUS AS INITIAL PRESENTATION OF CYSTIC FIBROSIS: A RETROSPECTIVE CASE SERIES FROM A MACEDONIAN PEDIATRIC CYSTIC FIBROSIS CENTER(University Ss. Cyril and Methodius in Skopje, 2025-12-16) ;Krsteska, Elena ;Spirevska, Lidija ;Andreevska Stepanovska, Andrijana; Jordanova, OliveraIntroduction: Meconium ileus (MI) is often the earliest clinical sign of cystic fibrosis (CF), caused by intestinal obstruction due to thickened meconium from CFTR dysfunction. MI is commonly associated with severe CFTR mutations (classes I-III), which impair chloride and bicarbonate transport. Case report: We report a retrospective case series of six neonates with MI, diagnosed with CF at Pediatric CF Center at University Children’s Clinic, Skopje, over the last eight years. During this period, newborn bloodspot screening (NBS) program for CF was conducted, based on two sequential measurements of immunoreactive trypsinogen (IRT) and IRT-IRT protocol. All infants presented with early intestinal obstruction requiring surgical intervention, including enterotomy and ileostomy. Postoperative care included pancreatic enzyme therapy and nutritional support. CF diagnosis was confirmed via sweat chloride testing and genetic analysis, which showed a predominant presence of the F508del mutation in homozygous or compound heterozygous forms. Despite timely surgical intervention, three infants experienced severe complications and early mortality. It is noteworthy that one of these cases had false-negative NBS result, highlighting limitations of the IRT-IRT protocol in MI cases. The remaining patients showed varied recovery and nutritional outcomes. Conclusions: MI is a known cause of false-negative results in CF NBS, as IRT levels may be low in affected neonates. Therefore, any newborn presenting with MI should be presumed to have CF until proven otherwise. Confirmation requires sweat chloride testing and genetic analysis. These findings support the need for revised CF NBS protocols in all MI cases to ensure timely diagnosis and management. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Current Status of Newborn Screening in Southeastern and Central Europe(MDPI AG, 2026-03-02) ;Požun, Nika ;Perko, Daša; ;Barić, IvoBaša, MihailNewborn screening (NBS) is a well-established public health program that enables early detection and treatment of rare disorders in newborns, preventing severe complications or death. Despite its recognized importance, the scope and implementation of NBS programs vary across Southeastern (SE) and Central Europe. This study aimed to evaluate the current status of NBS in 16 countries of SE and Central Europe and assess progress since the previous survey in 2021. A structured questionnaire was distributed to national experts between April and December 2025, collecting data on program organization, coverage, diseases included, laboratory methods, confirmatory testing, consent practices, and future expansion plans. All countries reported universal screening for congenital hypothyroidism, except Kosovo, where a national NBS is in the process of being established. Expanded NBS using tandem mass spectrometry was available in Austria, Bulgaria, Croatia, Cyprus, Greece, Hungary, North Macedonia, Romania, and Slovenia. Spinal muscular atrophy screening became universal in Austria, Croatia, Hungary, Serbia, and Slovenia. Most countries reported plans for further expansion, with congenital adrenal hyperplasia, severe combined immunodeficiency, spinal muscular atrophy, and cystic fibrosis being the most frequently targeted conditions. Although notable infrastructural progress has been achieved, financial constraints, lack of staff, and organizational barriers remain key challenges. The study’s assessment of program effectiveness was further limited by the absence of region-wide systems for capturing end-to-end performance indicators, such as the age of the infant at treatment initiation or missed cases. Regional collaboration and adoption of best practices are therefore vital to ensure equitable access and continuous advancement of NBS programs. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CLINICAL-PATHOLOGICAL EVALUATION AND FOLLOW-UP OUTCOMES IN PRIMARY BLADDER TUMOR PATIENTS TREATED AT UROLOGY CLINIC(Македонско лекарско друштво = Macedonian medical association, 2024); ; ;Trifunoski, Aleksandar ;Janchulev, JosifAim. To evaluate the clinical-pathological characteristics, recurrence rate, and progression of primary bladder tumors in patients treated at a tertiary urology center, with a focus on histologic grade, tumor size, and number assessed via cystoscopy. Methods. This retrospective, observational study included 117 patients with histologically confirmed urothelial carcinoma who underwent initial transurethral resection of bladder tumor (TURBT) at the University Clinic for Urology in Skopje from January 2019 to December 2024. Patients were categorized by gender, tumor invasiveness (pTa, pT1, pT2), histologic grade (PUNLMP, low-grade, high-grade), tumor count, and size. Follow-up was performed using cystoscopy, urine cytology, and ultrasound at 3, 6, 9, and 12 months. Recurrence was defined as tumor relapse at any of these intervals. Exclusion criteria were: non-urothelial histology, missing data, prior bladder cancer treatment, or carcinoma in situ (CIS), which was excluded due to its distinct biological behavior. Results. The mean age of patients was 66.5±9.6 years (range 41-88), with a male-to-female ratio of 3.5:1. Pathological staging showed 43 patients (33.9%) had pTa, 37(29.1%) had pT1, and 37(29.1%) had pT2 tumors. Histologic grading revealed 2 patients (1.6%) with PUNLMP, 37 (29.1%) with low-grade carcinoma, and 78 (64.6%) with high-grade tumors. Non-muscle invasive bladder cancer (NMIBC) was present in 80 patients (63.0%), and muscle-invasive bladder cancer (MIBC) in 37 (29.1%). Recurrence occurred in 14 of 117 followed patients (12.0%). There was no recurrence in PUNLMP cases: 16.2% of low-grade tumors, and 10.2% of high-grade tumors. The relatively lower recurrence in high-grade cases is attributed to the high proportion of pT2 tumors managed by cystectomy. Tumor multiplicity and size were significant predictors: recurrence was 4.8% in solitary tumors and 50.0% in patients with 3-5 tumors. Tumors >3 cm had a recurrence rate of 24.0%, compared to 5.7% in those <3 cm. Conclusion. Tumor grade, size, and multiplicity were strongly associated with recurrence following TURBT. These findings emphasize the importance of personalized follow-up based on pathological and cystoscopic features.
