Faculty of Medicine
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Item type:Publication, Evaluation of Neonatal Screening Programs for Tyrosinemia Type 1 Worldwide(MDPI AG, 2024-12-16) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MISMATCH REPAIR STATUS IN COLON CANCER: A SINGLE-CENTRE EXPERIENCE FROM NORTH MACEDONIA(2025-10-01); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Diet and sex inequities in ischemic heart disease mortality across Europe: findings from the global burden of disease study(Oxford University Press (OUP), 2025-11) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A challenging "silent depth" clinical scenario in North Macedonia: Unmasking a rare case of amelanotic melanoma with trapezius muscle invasion and metastatic disease(Centre for Evaluation in Education and Science (CEON/CEES), 2025); ; Aleksovski, DarkoIntroduction: Amelanotic melanoma is a subtype of melanoma that exhibits little or no pigment on visual or histological examination. Approximately 1-8% of all melanomas are amelanotic. It can mimic various benign or malignant melanocytic and non-melanocytic skin tumors, thereby presenting a significant diagnostic challenge. Primary amelanotic melanoma with muscle involvement is an extremely rare entity. A review of the literature revealed no series or case reports. Case Report: We present the case of a 62-yearold female patient with primary amelanotic melanoma infiltrating the trapezius muscle. The tumor was excised together with a clinically positive lymph node on the right side of the neck. Computed tomography (CT) angiography of the lungs, abdomen, and pelvis demonstrated bilateral diffuse nodular changes, a mediastinal pretracheal lymph node, and multiple diffuse liver lesions, consistent with secondary deposits. Molecular pathology revealed positivity for the BRAF V600E2/K/R/D mutation, and the patient began firstline targeted therapy with BRAF/MEK inhibition in accordance with protocols for BRAF-positive metastatic melanoma. Three months later, a follow-up CT scan demonstrated complete remission of the previously observed metastatic changes. Conclusion: Primary amelanotic melanoma with muscle involvement is exceptionally rare, with no published series or case reports identified. This case highlights the importance of early detection and treatment in suspected melanoma and underscores the need to consider melanoma in all clinically unclear cases. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Arthroscopy in Acute Ankle Fractures: A Weber Classification-Based Analysis(ISRES Publishing, 2025-10-01); Ankle fractures are common orthopedic injuries, often treated with open reduction and internal fixation (ORIF). However, 21% to 45% of patients report unsatisfactory outcomes, possibly due to intraarticular pathology. This study aimed to assess these injuries arthroscopically and statistically analyse their prevalence and relation to the Weber classification. A prospective cohort study was conducted on 48 patients with acute ankle fractures at the University Clinic for Surgical Diseases “St. Naum Ohridski” from January 2020 to January 2023. Patients underwent standard preoperative radiographic examinations and were classified according to the Weber classification, followed by arthroscopic intraarticular examination and ORIF. The arthroscopic examination evaluated syndesmotic injury, chondral lesions, loose bodies, and deltoid ligament injuries. Forty-eight patients were studied, with intraarticular pathology found in 33 cases (68.75%). For Weber fractures: type A had 58.33%, type B had 72.73%, and type C had 84.21% of intraarticular pathology. Syndesmotic injury appeared in 33.33% of type A, 50% of type B, and 41.67% of type C fractures. Chondral lesions occurred in 41.67% of type A, 54.55% of type B, and 66.67% of type C fractures. Loose bodies were detected in 8.33% of type A, 18.18% of type B, and 25% of type C fractures. Deltoid ligament injuries were observed in 16.67% of type A, 27.27% of type B, and 41.67% of type C fractures. The study concludes that arthroscopy during ORIF in ankle fractures is valuable for diagnosing intraarticular pathology. It highlights the Weber classification's importance, noting that type C fractures have a higher chance of such involvement. Understanding arthroscopy's diagnostic value in these cases helps surgeons decide on concurrent interventions during ORIF, potentially improving patient outcomes. Further research may investigate how arthroscopy-guided interventions affect clinical outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, POTENTIAL PATHOGENIC VARIANTS IN FANCM AND MUTYH GENES AND INTERGENIC REGIONS TO BREAST CANCER RISK(2025-10-01); ; ; - Some of the metrics are blocked by yourconsent settings
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