Faculty of Medicine

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    Gastric metastasis from high-grade soft tissue sarcoma: a rare occurrence with literature review
    (Oxford University Press and JSCR Publishing Ltd, 2025-03-15)
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    Angelovska, Tamara
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    Adem, Xhem
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    Todorova, Teodora
    Metastasis of high-grade soft tissue sarcoma to the stomach is an extremely rare occurrence. While sarcomas can spread to distant organs,they most commonly metastasize to the lungs,liver,and bones.We report a unique case of gastric metastasis from a high-grade soft tissue sarcoma,occurring 4 years after the initial diagnosis of fibrosarcoma in the right femoral region.The patient did not undergo adjuvant chemotherapy and developed a large soft tissue metastasis in the left gluteal region 2 years later. After 4 years, he presented with a second soft tissue metastasis and suspected metastatic lung nodules. Symptoms of melena and severe anemia prompted a gastroscopic examination, which revealed gastric metastasis from a high-grade soft tissue sarcoma. Due to severe anemia, a palliative gastric resection was performed.A review of the literature indicates that metastatic leiomyosarcomas are the most frequently reported sarcoma subtype metastasizing to the stomach.
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    DIAGNOSTIC CHALLENGE IN DISTINGUISHING BENIGN FROM RARE MALIGNANT UTERINE PATHOLOGY – A CASE REPORT OF A MYXOID LEIOMYOSARCOMA
    (SHMSHM - AAMD, 2023)
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    Gjoreski, Josif
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    Biljan, Aleksandra
    Leiomyosarcomas are rare aggressive soft tissue tumors, which account for 1 to 2% of all uterine malignancies. Due to their infrequency, as well as the difficulty to distinguish them from leiomyomas, the diagnosis is often made postoperatively. We report a case of a 38-year-old patient who was treated at the University Clinic for Obstetrics and Gynecology – Skopje for an enlarging uterine fibroid, for which she had undergone a myomectomy. The histopathology report showed that it was a case of a myxoid leiomyosarcoma, FIGO Stage IB, involving margins. She was admitted for a reoperation which consisted of a total hysterectomy, bilateral adnexectomy, selective lymphadenectomy and staging. The final postoperative clinical stage was FIGO IB. Leiomyosarcomas are generally less responsive to chemotherapy or radiation, most often have a poor prognosis and a high risk of recurrence. Surgery is the most significant treatment modality. The prognosis primarily depends on the FIGO stage, as the most important independent variable associated with survival.