Faculty of Medicine
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Item type:Publication, PREVALENCE OF PSYCHOSIS IN NORTH MACEDONIA FOR THE PERIOD FROM 2020 TO 2023(Macedonian Medical Association, 2025-09); The aim of the study was to estimate the prevalence of psychosis in the Republic of North Macedonia (RNM) for the period 2020-2023. Data from the Psychosis Registry of the Institute of Public Health - Skopje, as well as reports from the Public Health Centers in the Republic of North Macedonia, were used. A descriptive-analytical method was used to analyze and present the results. In 2020, the overall rate of psychosis cases was 134.88 per 100,000 population. In 2023, the rate doubled to 299.3 per 100,000 population. In 2023, the rate doubled to 299.3 per 100,000 inhabitants. The largest number of cases for the entire period was diagnosed in the population aged 45-54 years (3935). There are also regional differences, with the most cases documented in the Skopje (1462) and Pelagonia regions (1287). Conclusion: The trend of people suffering from psychosis in our country is continuously increasing. The most affected by this disease are males and the adult population. The results demonstrate the importance of early detection and targeted interventions to address the prevalence of psychosis across different population groups. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE AND IDENTIFICATION OF POTENTIAL PREDICTORS ASSOCIATED WITH GESTATIONAL DIABETES MELLITUS IM MACEDONIA(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2025-03-01); ; Ninova, AgavniIntroduction: Peripheral nerve blocks have an increasingly important role as an anesthetic technique for surgical anesthesia, postoperative analgesia, and fast discharge of patients after surgery involving the upper or lower extremities, alone or in combination with spinal or general anesthesia. Ultrasound guidance has become the most popular for performance of peripheral nerve blocks. Methods: In our retrospective study, we included all patients that were admitted in our hospital for orthopedic procedures on lower and upper extremities who received peripheral nerve block, alone or in combination with spinal or general anesthesia in the last 5 years. Ultrasound guidance was used and local anesthetic Bupivacaine 0.5%. Dexamethasone 4 mg was given intravenously as an adjuvant to peripheral nerve blocks. Results: The total number of patients included in our study was 300, the total number of performed peripheral nerve blocks was 302. 144 (48%) patients were male and 156 (52%) – female. The type of performed blocks was: 164 (54%) femoral, adductor canal blocks 22 (7.28%), 26 supraclavicular (8.60%), 77 interscalene (25.49%), 9 axillar (2.98%), 2 popliteal (0.66%), 1 iPACK and 1 TAP block (0.33%). Peripheral nerve blocks were combined with general or spinal anesthesia or performed as a sole technique for intraoperative analgesia in 17 patients (5.67%). Discussion: In our hospital we performed ultrasound guided peripheral nerve blocks last years in combination with a general, spinal anesthesia or as a sole technic for intraoperative and postoperative analgesia. Our patients were very satisfied with good postoperative pain control, and no serious complications were observed. Conclusion: Ultrasound guided peripheral nerve blocks are good choice for intraoperative anesthesia and postoperative analgesia, especially in older patients and patients with a lot of comorbidities. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Unveiling the neuropathology tumour landscape: 10-year statistical analysis with global comparison – Single centre experience(Macedonian Academy of Sciences and Arts, 2023-12); ; ; ; Introduction: Central nervous system (CNS) tumours represent a significant public health issue worldwide, and their incidence and distribution vary across different populations. Although studies on CNS tumours have been conducted in various countries, there is a lack of information regarding their patterns in Macedonia. Therefore, this study is aimed at investigating the distribution, histopathological types and subtypes and demographic features of CNS tumours in our country. Materials and Methods: A cross sectional study was conducted using the electronic database of the Institute of Pathology – Medical Faculty, University “Ss. Cyril and Methodius” in Skopje which contains data from 3286 received and analysed surgical specimens, mainly from the University Clinic of Neurosurgery in Skopje, and a smaller number of surgical specimens from the University Surgical Centre “St. Naum Ohridski” in Skopje between 2012 and 2022. The collected and analysed data includes patient age, sex and histopathological types and subtypes of the tumours. Results: The majority of CNS tumours were diagnosed in adults aged between 50-70, with a male to female ratio of 1.5:1. The most common location of the tumours was the cerebrum, followed by the pituitary gland and cerebellum. The most frequent histological groups were gliomas, with glioblastoma as the most common diagnosis, followed by meningiomas. Conclusion: Following a detailed and thorough review of the CNS tumours in our study, we can conclude that the R. of Macedonia follows global statistics and trends regarding brain tumours. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assosiation of COVID-19 Infection and Acute Mesenteric Ischemia(The First Faculty of Medicine of Charles University - Karolinum press, 2023-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE OF BACTERIAL VAGINOSIS(Institute of Knowledge Management, 2021)Bacterial vaginosis is a disorder in the composition of the vaginal flora that leads to a decrease in the number of hydrogen peroxide-producing lactobacilli and a predominance of various anaerobic bacteria. A retrospective cohort study, performed on a series of 192 patients aged 20 to 59 years, divided into two groups: study and control. The study group included 128 sexually active women with a Pap smear that showed the presence of a squamous intraepithelial lesion or squamous invasive cervical cancer. The control group included 64 sexually active women with a normal PAP test. In all women we done: Nugent's score system, and as indicated, all women in the study group and colposcopic cervical biopsy with endocervical curettage for histopathological analysis. Bacterial vaginosis was detected in 43.75% of patients with squamous cell abnormalities of the cervix and in 12.50% of patients with normal cervical cytology. Data analysis showed: correlation between the presence of bacterial vaginosis and the occurrence of squamous cell abnormalities of the cervix (chi-square test = 4.1906, p <0.05); increase in the presence of bacterial vaginosis with increasing cytopathological (chi-square test = 12,198, p˂0.05) and histopathological (chi-square test = 6.3434, p˂0.05) degree of cervical lesion and that bacterial vaginosis was most common in patients under 30 years of age (57.14%; 16/28). There is a statistically significant correlation between the modalities, the presence of bacterial vaginosis and the absence of bacterial vaginosis between the study and the control group (chi-square test = 18.75, p˂0.05). The percentage difference between the modalities presence of bacterial vaginosis and absence of bacterial vaginosis between the study and the control group was statistically insignificant for p˃0.05 (p = 0.1863, t = 1.9799, 95% CI = -138.8260-54,260). Our study showed an association between bacterial vaginosis and squamous cell abnormalities of the cervix. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prevalence of congenital hypothyroidism in North Macedonia: data from a newborn screening program conducted for twenty years(Turkish National Pediatric Society, 2023); ; ; Meceska Jovcevska, JasminaBackground. Congenital hypothyroidism (CH) is a common endocrine disorder that can be treated if timely detected by newborn screening, optimizing the developmental outcome in affected children. In the present study, we analyze the data of the national newborn thyroid screening program in North Macedonia collected over twenty years, including the CH prevalence as well as its geographical and ethnic variations. Methods. The thyroid-stimulating hormone (TSH) was measured on a filter paper blood spot sample using the DELFIA fluoroimmunometric assay. A TSH value of 15 mIU/L whole blood was used as the cutoff point until 2010 and 10 mIU/L thereafter. Results. Out of 377,508 screened live births, a total of 226 newborns with primary CH were detected, providing an overall prevalence of 6.0 per 10,000. Lowering the TSH cutoff led to an apparently increased prevalence of the transient CH, from 0.2 to 2.4 per 10,000 live births (p<0.0001) with an impact on the overall prevalence of primary CH (from 4.0 to 7.1 per 10,000, p=0.0001). Taking ethnicity into account, the significantly highest primary CH prevalence of 11.3 per 10,000 live births was observed among the Roma neonates, with a predominance of permanent CH (75.5%). There were also regional differences in the prevalence of primary CH. The highest primary CH prevalence of 11.7 per 10,000 live births was observed in the Vardar region, together with the highest regional prevalence of the transient CH (3.2 per 10,000). The highest prevalence of permanent CH was observed in the Pelagonia region (6.6 per 10,000) where the largest percentage of the Roma population lives. Conclusions. The overall CH prevalence is high in North Macedonia, with substantial ethnic and geographical variations. Further analysis to elucidate the causes for the significant variations in the CH prevalence including environmental factors is warranted - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREVALENCE OF VERTEBRAL FRACTURES IN POSTMENOPAUSAL PATIENTS WITH RHEUMATOID ARTHRITIS(Македонско лекарско друшство = Macedonian Medical Association, 2020-03); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COPD IN A SAMPLE OF GENERAL ADULT POPULATION FROM THE SKOPJE REGION(University Ss. Cyril and Methodius in Skopje, 2022); ; ; ; Atanasovska, AnetaIntroduction. Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity, disability and mortality in the last decades worldwide. Aim of the study. To determine the COPD prevalence in a sample of general adult population from the Skopje region and its distribution by sex, age, smoking status, working status, family history of chronic bronchitis/asthma, and mode of household heating and cooking. Methods. A cross-sectional study (prevalence study) including 2,348 participants (1,239 males and 1,109 females, aged 18 to 86 years) from the Skopje region was performed at the Institute for Occupational Health of RN Macedonia, Skopje, in the period 2018-2021. The study protocol included completion of a questionnaire and spirometric measurements (pre and post-bronchodilator spirometry). COPD was defined by spirometric finding of persistent airflow limitation in symptomatic study subjects. Results. COPD prevalence in the whole study sample was 4.6%, being non-significantly higher in men (5.1%) than in women (4.1%). Fourfold higher prevalence of COPD was registered in the study subjects aged over 45 years as compared to the younger ones (6.7% vs. 1.6%; P = 0.000). COPD prevalence was significantly higher in active smokers as compared to non-smoking study subjects (9.4% vs. 1.9%; P = 0.000). In regard to working status, COPD prevalence among active workers was 3.9%, in the group of retired persons 8.7%, while in the group of students there was not a single subject with COPD. In addition, COPD prevalence in the workers occupationally exposed to noxious particles or gases was significantly higher than in unexposed workers (4.7% vs. 2.4%; P = 0.021). There was no statistically significant difference in the COPD prevalence between study subjects with positive and negative family history of asthma/chronic bronchitis (4.8% vs. 4.5%), as well as between study subjects who used biomass fuels for heating and cooking (6.2%) and those who did not use traditional fuels for household needs (4.0%). Conclusion. Our findings have indicated the age, active smoking and occupational exposures to noxious particles or gases as the factors significantly related to COPD prevalence in the examined sample of general adult population from the Skopje region. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three(Elsevier BV, 2009-12)