Faculty of Medicine

Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14

Browse

Settings

Has files: YesSubject: search.filters.subject.chronic kidney disease

Search Results

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Early Detection of a Kidney Disease – Where do we Stand Today?
    (Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs, 2025-12)
    Kostovska, Irena
    Chronic kidney disease (CKD) represents a major global health burden, with early detection of glomerular injury remaining a persistent clinical challenge. The urinary albumin-to-creatinine ratio (UACR), although widely accepted as a diagnostic and prognostic marker, primarily reflects established structural damage. Urinary nephrin, a podocyte-specific transmembrane protein integral to the slit diaphragm, has emerged as a sensitive and mechanistically precise indicator of early podocyte injury. Detection of nephrinuria precedes the onset of albuminuria and correlates with disease activity across diabetic nephropathy, preeclampsia, and immune-mediated glomerulopathies. Comparative evaluation suggests that nephrinuria provides superior temporal and pathophysiological insight into glomerular injury. Incorporation of urinary nephrin into clinical practice, alongside UACR, holds potential to refine early CKD diagnostics and to facilitate a transition toward precision-based renal risk assessment and timely therapeutic intervention.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Two Pregnancies with a Different Outcome in a Patient with Alport Syndrome
    (Scientific Foundation Spiroski, 2016-09-15)
    ;
    ;
    BACKGROUND: Alport syndrome is a genetic disease that progresses to chronic kidney failure, with X-linked, autosomal dominant or autosomal recessive type of inheritance. Women are generally carriers of the mutation and have a milder form of the disease. During pregnancy, they have an increased risk of impaired kidney function and preeclampsia. CASE PRESENTATION: A 27-year old woman, gravida 1, para 0, in her 23rd gestational week came to the outpatient unit of the University Clinic of Nephrology for the first time because of slowly progressing proteinuria and Alport syndrome. She was admitted to the gynaecological ward in her 29th gw for proteinuria which increased from 3.8 g/day up to 20 g/day and the serum creatinine increased to 120- 150 micromol/l. She was delivered in the 30th gestational week due to obstetrical indications with a cesarian section and delivered a baby with a birth weight of 880 g. After delivery, proteinuria decreased to 2 g/d within 2 months and an angiotensin-converting enzyme inhibitor (ACEI) was started. Her second pregnancy, after 2 years, had an uneventful course and she delivered a healthy baby weighing 3000 g in the 39th week. Six months after the second delivery, her renal function remained normal and her proteinuria was 2 g/d. CONCLUSIONS: Pre-pregnancy counselling and frequent controls during pregnancy are necessary for women with Alport syndrome, as well as regular monitoring after delivery. Recent reports are more in favour of good pregnancy and nephrological outcomes in women with Alport syndrome when renal disease is not advanced.