Faculty of Medicine

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LAPAROSCOPIC VERSUS OPEN KASAI PORTOENTEROSTOMY FOR BILIARY ATRESIA: A SYSTEMATIC REVIEW AND META-ANALYSIS BY THE PEDIATRIC SURGERY META-ANALYSIS STUDY GROUP (PESMA)
(European Society of Paediatric Endoscopic Surgeons, 2025-10)
Duygu Gurel
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Mustafa Azizoglu
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Carlos Delgado Miguel
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Federica Pederiva
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Mehmet Hanifi Okur
Introduction: Biliary atresia (BA) is a rare but life-threatening neonatal liver disease requiring timely surgical intervention. The Kasai portoenterostomy (KPE) is the standard treatment, traditionally performed via laparotomy. Recently, laparoscopic approach has been introduced, but its efficacy remains debated. This systematic review and meta-analysis compared laparoscopic and open KPE in patients with BA. Methods: A comprehensive literature search of PubMed, Scopus, EMBASE, and Web of Science was conducted through April 2025. Primary outcomes were jaundice clearance, cholangitis, overall complications, 2-year native liver survival rate, and postoperative intestinal obstruction. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using Mantel–Haenszel methods under fixed- or random-effects models, based on heterogeneity (I²). We used RevMan 5.4 software meta-analysis statistic program. Results: A total of 26 studies were included. Jaundice clearance (17 studies; OR=1.10; 95%CI: 0.76–1.59; p=0.61; I²=42%) and cholangitis (15 studies; OR=1.17; 95%CI: 0.87– 1.59; p=0.30; I²=0%) rates showed no significant differences between laparoscopic and open groups. No significant differences were observed in overall complication rates (8 studies; OR=0.71; 95%CI: 0.24–2.09; p=0.54; I²=57%). Postoperative intestinal obstruction (7 studies) and 2-year native liver survival (8 studies) also showed comparable outcomes (OR=0.91; 95% CI: 0.36–2.27; p=0.83; I²=0% and OR=0.74; 95% CI: 0.49–1.10; p=0.13; I²=30% respectively). Conclusion: Laparoscopic KPE appears to be a safe and feasible alternative to the open approach, with comparable outcomes across major clinical parameters. While current evidence supports its feasibility, further high-quality prospective studies are needed to validate these findings and inform surgical practice.
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The suprising stories of the acute abdomen:Tosion of the appendix vermiformis
(2025-04)
Srbakovska, Bisera
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Ognenoska, Biljana
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Acute appendicitis is the most common cause of acute abdominal pain needing surgical treatment. However, it can be clinically and radiologically mimicked by other conditions, some of them with an extremely rare occurrence. A two year old boy presented to our hospital with a history of abdominal pain and vomiting in the last 48 hours. On physical examination, the patient was found to be dehydrated, with a dry mouth and a white-coated tongue. Tenderness was noted throughout the entire abdomen, with rigidity and guarding, especially in the right lower quadrant. Laboratory results showed an elevated Creactive protein level of 50.2 mg/L and a white blood cell count of 25,800/μL. Under the suspicion of acute complicated appendicitis, emergency McBurney laparotomy was performed. Operative findings revealed an enlarged, dark purple, congested appendix, twisted 720° around its base at the cecum in the anticlockwise direction. There was no evidence of perforation. A typical appendectomy was performed. The postoperative course was uneventful and the patient was discharged home on the fourth post-operative day. Microscopic examination confirmed the hemorrhagic infarction and ischemic necrosis of the appendix, followed by an inflammatory reaction caused by the torsion. To our knowledge only 22 cases of torsion of the vermiform appendix in children have been reported in literature, with our case being the 23rd. Though extremely rare, it should be considered as a potential diagnosis in patients presenting with right lower abdominal pain. Histopathology is crucial in differentiating primary from secondary causes of appendicular torsion.
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COMPLICATED TUBERCULOSIS IN A 13-YEAR-OLD CHILD WITH DOWN SYNDROME: A CASE REPORT
(Macedonian Association of Anatomists and Morphologists, 2023-11-05)
Nestorov, Hristijan
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Doksimovski, Filip
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Chakalaroska, Irena
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Ivanovska, Julija
Tuberculosis (TB) is the most common cause of infectious disease-related mortality worldwide. Most persons infected won’t develop active disease, but in certain instances such as extremes of age or defects in cell-mediated immune response, TB may develop. Down syndrome (DS) is the most common neurodevelopmental disorder of know genetic causeand described simply as arising from an extra copy of chromosome 21, presenting with characteristic features. Due to immune defects, DS suffer more frequently from respiratory tract infections than normal children.We present a case of a 13yearsold child with Down Syndrome who was diagnosed with lung tuberculosis, after a right sided lobectomy due to a lung abscess.The child was hospitalized, following a period of one and a half month with fever and vomiting that did not improve with therapy. Investigations were made, including CT scan on the lungs. Due to right sided empyema and abscess on the right upper lobe, right sided lobectomy was preformed. The postsurgical pathohistological findings were in addition to pulmonary tuberculosis. Four drug antituberculosis regimenwas started. The four-drugcourse was given for two months, and then a two-drugregime was continued. To this day the child is on the sixth month of the two-drugantituberculosis regime. CT scans, regular Chest X-rays and ultrasoundof the lungs were made, with gradual improvement.In Down syndrome patients who have a complicated pneumonia that doesn’t respond to standard treatment, a tuberculosis disease should be considered.
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Treatment of acute postoperative pain, the new face of multimodal analgesia
(Serbian Society of Pain, Belgrade, Serbia, 2023-05-23)
Ivana Budic
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Vesna Marjanovic
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Ivana Gajevic
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Jelena Lilic
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Marija Stevic
19 Treatment of acute postoperative pain, the new face of multimodal analgesia Ivana Budić1,2, Vesna Marjanović1,2, Ivana Gajević2, Jelena Lilić2, Marija Stević3,4, Marija Jovanovski-Srceva5,6, Dušica Simić3,4 1Department of Surgery and Anesthesiology, Medical Faculty, University of Niš, Serbia; 2Clinic for Anesthesiology and Intensive Therapy, University Clinical Center Niš, Serbia; 3Department of Surgery and Anesthesiology, Medical Faculty, University of Belgrade, Serbia; 4University Children’s Hospital, Belgrade, Serbia; 5University Clinic for TOARILUC, Skopje, N. Macedonia; 6 Medical Faculty, UKIM, Skopje, N. Macedonia ABSTRACT Management of pain remains undertreated in the pediatric population. Multimodal an- algesia (MMA) integrates the use of several analgesic medications, each of which targets a different pain-related receptor, and thereby exhibits its pain reducing effect by way of a different mechanism of action. MMA approach to pain management includes phar- macologic and non-pharmacologic options. Effective postoperative analgesia in infants and young children continues to evolve with innovative methods of therapy using new- er drugs or older drugs introduced via novel routes.
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CONGENITAL HYDRONEPHROSIS: DISEASE OR CONDITION?
(Macedonian Academy of Sciences and Arts / Sciendo, 2014)
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SImeonov R
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Chadikovski V
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Abstract The aim of this paper is to address the dilemmas of the paediatric surgeon when facing an isolated, unilateral, congenital hydronephrosis and discuss the strategic options for the management of this condition. Congenital hydronephrosis, the most commonly diagnosed uropathy in children, is usually a benign and self-resolving condition. Nonobstructive hydronephrosis does not require operative treatment, while timely treatment is imperative for obstructive hydronephrosis before significant renal damage ensues. Managing congenital hydronephrosis is a challenging task. Thirty-two children with unilateral, isolated hydronephrosis and nonobstructed renography curves were followed up for 3 years. On the initial evaluation according to the grade of hydronephrosis: 22.6% were grade I, 54.8% grade II and 22.6% grade III. After 12 months of follow-up: 30% were grade I, 51.5% grade II and 18.5% grade III, respectively. After the three-year follow-up, there were no hydroneproses greater than grade II. The mean value of the separate GFR of the affected kidney at initial evaluation was 42.83%, and 40.33% after three years. In three children the treatment was converted from conservative to surgical. Nonobstructive, congenital hydronephrosis is a benign condition not requiring any medical treatment, but aggressive observation is indicated.
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A Snapshot of European Children’s Eating Habits: Results from the Fourth Round of the WHO European Childhood Obesity Surveillance Initiative (COSI)
(MDPI AG, 2020-08-17)
Williams, Julianne
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Buoncristiano, Marta
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Nardone, Paola
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Rito, Ana Isabel
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Spinelli, Angela
Consuming a healthy diet in childhood helps to protect against malnutrition and noncommunicable diseases (NCDs). This cross-sectional study described the diets of 132,489 children aged six to nine years from 23 countries participating in round four (2015–2017) of the WHO European Childhood Obesity Surveillance Initiative (COSI). Children’s parents or caregivers were asked to complete a questionnaire that contained indicators of energy-balance-related behaviors (including diet). For each country, we calculated the percentage of children who consumed breakfast, fruit, vegetables, sweet snacks or soft drinks “every day”, “most days (four to six days per week)”, “some days (one to three days per week)”, or “never or less than once a week”. We reported these results stratified by country, sex, and region. On a daily basis, most children (78.5%) consumed breakfast, fewer than half (42.5%) consumed fruit, fewer than a quarter (22.6%) consumed fresh vegetables, and around one in ten consumed sweet snacks or soft drinks (10.3% and 9.4%, respectively); however, there were large between-country differences. This paper highlights an urgent need to create healthier food and drink environments, reinforce health systems to promote healthy diets, and continue to support child nutrition and obesity surveillance.

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