Faculty of Medicine
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Item type:Publication, Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2024-11); Conditions that affect plasma concentrations of acute-phase proteins include infections, trauma, surgical treatment, burns, tissue ischemia (infarctions), various immunological inflammatory conditions and cancer. The cytokine Interleukin-6 (IL-6) is the main stimulator for the production of numerous acute-phase proteins. It has been established that the induction of C-reactive protein (CRP) and production of serum amyloid A is caused by the cytokines IL-6 and IL-1 or TNF-alpha. Elevated levels of IL-6 during acute injuries or stress are often used as an indicator of systemic inflammation and are predictors of preoperative morbidity. We undertook this prospective randomized study in 90 patients undergoing surgery procedure after high-energy trauma, low-energy trauma and open fracture to define plasma levels of IL-6 and CRP over a 2-week period. We presented our results at seven time points, namely 6 hours pre-operatively and post-operatively in 2, 4, 5, 7 and 14 days respectively. We have attempted to find out whether IL-6 and CRP levels returned to baseline during this study period. In our study, we determined the influence of the examined parameters CRP and IL-6 in plasma on the early detection of surgical postoperative inflammation in operatively treated fractures. With the obtained results of our examined parameters, we can state that is provided a place for the routine procedure of CRP and IL-6 as predictors of possible postoperative inflammation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, C-REACTIVE PROTEIN IN RHEUMATOID ARTHRITIS TREATED WITH INTERLEUKIN-6 INHIBITOR(Macedonian Medical Association/De Gruyter, 2022); ; Arton JakupiRheumatoid arthritis (RA) is a chronic immune-me-diated systemic inflammatory disease characterized by chronic synovial inflammation and hyperplasia, which cause joint erosion and damage along with systemic manifestations. Proinflammatory pathways result in localized joint and systemic inflammation with cytokines, such as interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), interleukin 1β (IL-1β), as well as downstream signalling pathways. One function of IL-6 is to drive production of the acute-phase reactant C-reactive pro-tein (CRP) following an inflammatory event. C-reactive protein is not only a marker of inflamma-tion or infection, but it is also an immune regulator. C-reactive protein level is a component of several com-posite disease activity measures. Higher CRP levels are associated with greater RA disease activity, radiogra-phic progression and joint destruction. Yet, the usefulness of CRP testing as a routine measure of RA disease activity is not universal due to the sub-stantial proportion of treated patients who experience flares in their RA but still have normal CRP levels. There may be challenges in assessing remission with 28-joint Disease Activity Score -CRP (DAS28-CRP) when patients are treated with IL-6 inhibitors and other drugs that directly affect CRP levels because a reduction in CRP may not reflect disease activity decrease. The case that we present is a patient with seropositive RA in whom we tried all available RA treatment modalities including IL-6 inhibitor and two other biologicals, and despite the fact that we achieved low disease activity and sometimes even remission of the underlying disease, radiographic progression and sub-jective complaints of the patient continued. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Diagnostic and predictive potential of the c-reactive protein in serum and ascites for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites.(Macedonian Association of Anatomists and Morphologists, 2021); ; ; ; Spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis is a spontaneous bacterial infection of sterile ascites fluid in the absence of intra-abdominal sources of infection or malignancy. The purpose of the study is to determine the diagnostic and predictive potential of CRP in serum and ascites, as an inflammatory indicator of SBP in patients with liver cirrhosis and ascites and to compare the mean values of CRP in serum and ascites in patients with and without SBP. In this prospective-observational study were included 70 patients with cirrhosis and ascites, divided into two groups, SBP and non-SBP group. Quantitative measurement of CRP in serum and ascites was determined by immunoturbidimetric method using latex particles. The average value of CRP in serum in SBP group was 35.4 ± 29.51 mg / L, and in control non-SBP group it was lower (18.6 ± 18.71 mg/L), and this difference was statistically significant for p = 0.006132. The average value of CRP in ascites in SBP group was 7.3 ± 7.2, and in non-SBP group it was lower (2.9 ± 3.1l), with statistically significant difference of p = 0.001604. ROC analysis indicates that CRP contributes to the diagnosis of SBP with 71.0% (p = 0.003) (good predictor). Univariate analysis showed that serum CRP> 6 mg / L and CRP in ascites> 6 mg / L significantly increased the chance of SBP by seven times ((Exp (B) = 7,319) and three times ((Exp (B) = 3,059), respectively. Our research confirmed that serum CRP is a good predictor, significantly associated with the occurrence of SBP in patients with liver cirrhosis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Carotid Artery Disease and Lower Extremities Artery Disease in Patients with Chronic Obstructive Pulmonary Disease(Scientific Foundation SPIROSKI, 2019-07-15); ; ; Doneva, AnaTo assess the frequency of carotid artery disease (CAD) and lower extremities artery disease (LEAD) in patients with chronic obstructive pulmonary disease (COPD) and their relation to the severity of airflow limitation and the level of C-reactive protein (CRP). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LOW-GRADE SYSTEMIC INFLAMMATION IN PATIENTS WITH STABLE CHRONIC OBSTRUCTIVE PULMONARY DISEASE(Association of pulmologists from Republika Srpska, 2019-05); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EVALUATION THE VALUE OF INFLAMMATORY BIOCHEMISTRY MARKERS AT THE NEWBORNS WITH SEPSIS IN THE INTENSIVE CARE UNIT(SHMSHM / AAMD, 2020); ; ; Olivera JordanovaObjective: The aim of this study was to evaluate the predictive values of procalcitonin (PCT) as a early diagnostic and prognostic biochemical marker for sepsis in newborns in correlation withC reactive protein (CRP) and white blood cells count(WBC). Methods: In a prospective study, 110 newborns with two or three clinical signs of sepsis who admitted at the Intensive Care Unit (ICU) at the PHI University Clinic of Pediatric Diseases-Skopje were included . Diagnosis of sepsis in newborns diagnosed according to standard protocols for diagnosis of disease. Sample for blood culture, PCT CRP and WBC obtained by peripheral venous puncturewere taken the first at the admission, before initiation of antibiotic therapy in newborns suspected of sepsis, the second on 3-5 days and the third 6-14 days. Results: 110 newborns were recruited. At first 24 hours of the admission , PCT have a higher discriminative ability than the WBC in distinguishing a bacterial infection from another inflammatory process the early infection diagnosis, and also found to have been more reliable than that of the CRP. The highest average values of PCT (40.37±53.79) were measured during admission with a subsequent sharp jump. The highest average values of CRP were measured (42.17±61.84) after the second during with a subsequent sharp jump. In the three measurements they had an average value WBC (16.83±8.35, 16.71±9.64. 16.31±11.72).Conclusion: The values of procalcitonin (PCT) is a important clinical significance in diagnosis treatment and predicting the prognosis of newborns with sepsis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE SIRS SCORE RELEVANCE FOR ASSESSMENT OF SYSTEMIC INFLAMMATION COMPARED TO C-REACTIVE PROTEIN IN PATIENTS WITH LIVER CIRRHOSIS(Македонско лекарско друштво = Macedonian Medical Association, 2019); ; ;