Faculty of Medicine

Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14

Browse

Settings

Has files: YesLanguage: search.filters.language.English (United States)

Search Results

Now showing 1 - 10 of 123
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Prevalence and Characteristics of Allergic Asthma in a Sample of Dairy Farmers
    (Scientific Foundation Spiroski, 2024-01)
    ;
    ;
    ;
    Atanasovska, Aneta
    ;
    Bislimovska, Dragana
    AIM: The objective of the study is to evaluate the prevalence characteristics of allergic asthma in a sample of dairy farmers. METHODS: We performed a cross-sectional study including 83 dairy farmers (mean age: 52.6 ± 8.7 years; mean exposure duration: 23.7 ± 7.6 years) compared to 80 office controls (mean age: 52.7 ± 8.2 years) matched for age, smoking habits, and socioeconomic status. Methods of evaluating examined subjects included a questionnaire on respiratory symptoms in the past 12 months, baseline spirometry and histamine challenge, and skin prick tests to standard inhalant and occupational allergens. RESULTS: The frequency of asthma was non-significantly higher in dairy farmers than in controls (7.2% vs. 5%). The frequency of allergic asthma was non-significantly higher in dairy farmers than in controls (6% vs. 3.8%). The frequency of allergic asthma was significantly higher compared to non-allergic asthma in both groups, while the frequency of subjects with allergic asthma who are sensitized to occupational allergens (wheat, corn, rye, cow hairs, molds) was similar in dairy farmers and controls. The risk of sensitization to occupational allergens was non-significantly higher among dairy farmers with allergic asthma (OR = 1,39 [0,18–12,28] CI 95%), compared to office controls. The risk for asthma development was non-significantly higher in subjects sensitized to occupational allergens compared to those who are not sensitized to them both in dairy farmers (OR = 2.00 [0.11–40.60] CI 95%) and office controls (OR = 3.00 [0.00–197.11] CI 95%). The risk for asthma development was about 4 times higher in subjects with atopy compared to those without atopy among dairy farmers (OR = 4.00 [0.22–104.88] CI 95%), while in office controls was almost identical (OR = 1.00 [0.00–39.77] CI 95%). Having in mind sensitization to certain inhalant allergens, asthma was significantly associated with sensitization to Dermatophagoides pteronyssinus both in dairy farmers (p < 0.01) and office controls (p < 0.05). CONCLUSION: The results suggest that occupational exposure among dairy farmers was associated with a higher prevalence respiratory symptoms, lung function impairment, and allergic asthma development. Study findings also can contribute in the detection of critical points for action, predict asthma development, and indicate the need for reduction of adverse occupational exposures by appropriate preventive measures, use of respiratory protective equipment, and implementation of engineering controls.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    The occurrence of acute subdural haematoma and diffuse axonal injury as two typical acceleration injuries
    (Elsevier, 2012)
    ;
    ;
    ;
    ;
    Popevska, Z
    Closed head injuries have already been classified into contact injuries and acceleration–deceleration injuries. Two typical acceleration–deceleration injuries and at the same time, the two worst head injuries are acute subdural haematoma (ASDH) and diffuse axonal injury (DAI), and that is where they got their medico-legal importance. Using experiments, it has been shown that acceleration with an impact time of more than 20–25 min (which occurs in traffic accidents in real life) causes DAI, whereas an impact time of 5–10 min is more likely to produce acute subdural haematoma. The aim of this research is to show that not all, but some types of traffic accidents are more typical for the occurrence of DAI, as well as that the ASDH is not a common feature for all types of fall. The analysis conveyed covered 80 cases of closed head injuries (traffic accidents, falls and assaults) where a complete forensic medical autopsy has been undertaken, followed by a complete forensic–neuropathological examination. For the purpose of diagnosing DAI, immunohistochemistry using antibody against β-amyloid precursor protein has been involved. Results show that ASDH is more likely to occur in cases of simple fall, assaults and cyclists and DAI is more typical for vehicular traffic accidents and cases of falling from a considerable height. The paper also comprises discussion about some open questions regarding the diagnosis of DAI in the medico-legal practice.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Dilemmas concerning the diffuse axonal injury as a clinicopathological entity in forensic medical practice
    (Elsevier, 2012)
    ;
    ;
    ;
    ;
    Popevska, Z
    Dilemmas and discussions concerning the diffuse axonal injury (DAI) and still existing in forensic medical practice are as it follows: 1. Whether the occurrence of DAI can indicate the type of traumatic event that has caused the head trauma, 2. Whether the presence of axonal damage in cases of hypoxia, ischaemia and other pathological conditions casts a shadow on the post-mortem pathological diagnosis of DAI and totally negates it, or there are certain clues in the findings that can point to the aetiology of the axonal damage. This paper discusses our findings based on neuropathological examination of 60 forensic cases of closed head injury. The neuropathological examination included: a macroscopic examination of the coronal sections and a microscopic examination involving an immunohistochemical method with antibody against β-amyloid precursor protein. Our findings indicate that DAI, as a clinicopathological entity, is undoubtedly an acceleration–deceleration injury, predominant in road traffic accidents as it is classically outlined, and cases of falling from a considerable height. Our findings point to a certain difference between the features of traumatic and ischaemic axonal damage. In this paper we also investigate the correlation between pathological grades of DAI and the impairment of the brain function before death.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    SEASONAL VARIABILITY OF (25OH) VIT D IN OBESE WOMEN IN NORTH MACEDONIA
    (Македонско лекарско друштво = Macedonian medical association, 2023)
    ;
    Sonja Panovska
    ;
    ;
    ;
    Petrit Izairi
    Introduction. Every year, 15 million infants are born prematurely, and 1 million of them surrender to preterm birth complications, accounting for 1 in every 3 neonatal deaths. Globally, about 28.5 premature births occur per minute, resulting in approximately 4 fatalities, with 2 of these attributed to respiratory distress syndrome (RDS). This study aimed to investigate how betamethasone affects fetal lung development by assessing fetal lung volume and its association with neonatal RDS. The study received ethical approval by the Ethics Committee of the Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia. Methods. This prospective clinical observational-interventional study involved 100 patients, including 50 with a history of preterm birth (study group) and 50 full-term cases (control group). The study was conducted at the University Clinic for Gynecology and Obstetrics, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, North Macedonia. Fetal lung volume was measured before and after betamethasone therapy, and its relation to neonatal RDS was evaluated. Patients were categorized into five groups based on gestational weeks. Results. Significant differences in total fetal pulmonary volume were observed before and after betamethasone treatment. Additionally, the measurement of total fetal lung volume has proved to be effective in predicting neonatal respiratory distress syndrome. Conclusion. Total fetal pulmonary volume measurement is a highly sensitive and specific method for predicting fetal lung maturity. This non-invasive, cost-effective, and easily accessible technique can be routinely employed in hospitals equipped with suitable ultrasound devices and adequately trained staff.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Validation of the ELISA Method for Quantitative Detection of TNF-α in Patients with Intracerebral Hemorrhage
    (Scientific Foundation SPIROSKI, 2017-09)
    ;
    Aleksovski, Boris
    ;
    Stojanov, Dragan
    ;
    Mihajlovska-Rendevska, Ana
    ;
    Aleksovski, Vasko
    <jats:p>AIM: We aimed to investigate the sensitivity, reproducibility and validity of the commercial ELISA kits for quantitative detection of TNF-α and their potential application for screening purposes in patients with ICH.METHODS: Analysis of six independent standard series, evaluation of the deviation of the TNF-α concentration in patients with ICH, standard addition and visual analysis of whole UV-Vis spectra were carefully performed.RESULTS: Low standard deviations of the absorbance were detected for every standard, as well as in the samples of healthy controls and patients with ICH. The standard addition series have also confirmed high sensitivity and reproducibility of the assay, with a congruent shift of the standard curves with the concentration of TNF-α for the added plasma. The visual analyses of the gained spectra have revealed the absence of any matrix effects from the addition of the human plasma in the reconstituted standards.CONCLUSION: The commercial ELISA kits can be used in the clinical practice for screening purposes of the plasma TNF-α levels in patients with ICH.</jats:p>
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    SARS-CoV-2 vaccination to support safe surgery during the pandemic: a modelling study using data from an international prospective cohort study
    (Oxford University Press on behalf of BJS Society Ltd, 2021)
    ;
    ;
    ;
    ;
    Cokleska Shuntov, Natalija
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Work Ability in Patients with COPD: Sick Leave Frequency and Duration
    (International Journal of Clinical Studies and Medical Case Reports, 2023-09-04)
    ;
    ;
    ;
    Atanasovska, Aneta
    ;
    Panajotovic-Radevska, Maja
    Introduction: Findings of several studies indicated that chronic obstructive pulmonary disease (COPD) affects patients’ work ability and everyday life activities. Aim of the study: To compare frequency and duration of absence from work in workers with COPD and non-COPD controls. Methods: We performed a cross-sectional study including 114 workers with COPD (63 males and 51 females, mean age 53.2 ± 3.7) and an equal number of non-COPD controls (60 males and 54 females, mean age 52.7 ± 3.1), classified by skill level in four occupation groups. Evaluation of the study subjects consisted of completion of a questionnaire, baseline spirometry, and bronchodilator reversibility testing. Results: Frequency of the sick leave episodes was significantly higher in workers with COPD than in non-COPD controls (44.7% vs. 20.1%; P = 0.004). In addition, frequency of sick leave episodes was higher in all occupation groups of workers with COPD than in non-COPD controls with significant difference for the workers performing physical or manual tasks (48.3% vs. 21.2%; P = 0.045). In regard to duration of sick leave episodes, the frequency of episodes lasting equal or less than 15 days and more than 15 days was higher in workers with COPD being significantly higher for episodes longer than 15 days (50.9% vs. 26.9%; P = 0.045). Conclusion: Our findings indicated significantly higher frequency of sick leave episodes, as well as significantly higher frequency of sick leave episodes lasting more than 15 days, in workers with COPD than in non-COPD controls.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Cardiac structure and functon of elite volleyball players across different playing position
    (Edizioni Minerva Medica, 2022)
    Alreyami Shihab
    ;
    Ebrahim Khosrow
    ;
    Sajad Ahmadizad
    ;
    Hirofumi Tanaka
    ;
    BACKGROUND: Volleyball is a popular Olympic sport but has been little studied. Volleyball players have very distinct roles based on their playing positions. The present study aimed to investigate and compare cardiac functions and structure in elite volleyball players across different playing positions. METHODS: Left ventricular structure and function were measured using echocardiography in 60 male professional volleyball players (30.6±3.6 years) across five playing positions including libero, opposite players, outside hitters, middle blockers, and setters. RESULTS: Significant differences in most echocardiographic variables were observed among different playing positions, including left ventricular (LV) internal dimension, posterior wall thickness, intact ventricular septum, stroke volume, cardiac output, end-diastolic volume, ejection fraction, and fractional shortening (all p<0.01). End-systolic volume was not different among positions (p=0.167). The opposite players demonstrated greater LV dimension and thickness as well as systolic function than players in other positions (p<0.05). Stroke volume in the setters was significantly lower than those of the opposite players and outside hitters (p<0.05). Regression analysis showed that the playing position independently predicted most of the echocardiographic variables (p<0.05). CONCLUSIONS: LV adaptations in volleyball players vary widely according to their playing positions. The opposite players had the most pronounced LV adaptations compared with player in other positions.