Faculty of Medicine
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Item type:Publication, Association Between the Polymorphism of Angiotensin-Converting Enzyme Gene and Interleukin-1 Beta Gene and the Response to Erythropoietin Therapy in Dialysis Patients with Anemia(Walter de Gruyter GmbH, 2023-12); ; ; The polymorphism of the angiotensin-converting enzyme (ACE) gene and interleukin-1 beta (IL-1b) gene could be associated with resistance in the treatment of anemia in dialysis patients with recombinant human erythropoietin (rHuEPO). The aim of the study was to evaluate the association between the polymorphism of the ACE and IL-1b genes and the response to rHuEPO therapy in dialysis patients with anemia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Attrition in Everyday Dental Clinical Practice(Macedonian Academy of Sciences and Arts/De Gruyter, 2024-12); ; Introduction Attrition, its prevention and therapy is a complex problem, with a multifactorial etiology. The aim of this paper is to examine the treatment of attrition in everyday dental clinical practice with the help of soft inserts. Material and method In this study, 30 patients were included, divided into two groups of 15 patients, the study and the control group. The examined patients had first degree of attrition diagnosed according to the Bardsley index, after which the condition was noted in four intervals: the initial situation, after 2, 4 and 6 months from the first visit. The research data were processed in Statistica for Windows 7.0 and SPSS version 20, and the same were presented graphically. Results In the study group with I degree of attrition, for p>0.05, no statistically significant difference was determined in the range of the Bardsley index between the four measurement times (Friedman Test: N=15; Chi-Square=7,200; df =3; p=0.0658). In the control group, for p<0.05, a significant difference was determined in the range of the Bardsley index between the four measured times (Friedman Test: N=15; Chi-Square=15.180; df=3; p=0.0017) with a significantly high value after 6 months. Discussion From the results obtained when comparing the study group in patients with I degree of attrition and the control group, a negative change from the parafunction bruxism was observed in 20% of the test group and 47% of the control group. The results of our research indicated that in patients with the first degree of attrition from the study group, soft dental inserts give significantly better results than untreated patients in the control group. This correlates with the research of Khayat N. et al. Conclusions From the results of the subjects in the group with I degree of attrition, we can conclude that the soft inserts has great efficiency as a means of management of this parafunction and therefore its application in daily therapy is recommended. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Anxiety in acute myocardial infarction survivors(SHMSHM / AAMD, 2020); ; Sevime Sallahi PasholliIntroduction :Data obtained in some studies indicate that somatic disorders, in a certain percentage, are associated with a mental health problems, whether in a form of two co-existent diseases, whether psychological problems are only associated symptoms and/or response to somatic disease. Anxiety is psychological symptoms frequently encountered in patients suffering from acute myocardial infarct (AMI). The AIM of our study was to determine the percentage of anxiety in two investigated groups of patients with myocardial infarction and to determinate the correlation between socio-demographic characteristic and level of anxiety in survivors of AMI. Material and methods: The study was designed as observation cross-section including 80 patients treated at the university Clinic of Cardiology Skopje , observed as 2 groups : group 1 was presented with patients during hospitalization for AMI, and 2 group were patients survivors after 6 months of the acute coronary event. Anxiety status was assessed using HAMA scale. Results : The two groups of patients did not show significant difference according distribution of gender , smoking , physical activity, stress , age, mean HAMA , BMI , age of education and marital status . In the first group 21 (51,2%) of patients have anxiety symptoms while in second group 25 (64,1%). In our study acute MI was more prevalent in a men but women had a higher risk of anxiety disorders 27,3% v.s (22,7%). In examination groups the anxiety (HAMA score) was positive correlate with socio-demographic and clinical parameters where only we got negative correlate between anxiety with marital status and BMI in the first group and negative correlation with married status, smoking status, physical activity, stress and BMI in the second group . .Conclusion: The results in our study showed indicative representation of anxiety in patients survivors of AMI. So screening for anxiety in all AMI patients is also important because this patients should be treated differently than those who are not anxiety. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, QUALITY OF LIFE, FORCED EXPIRATORY VOLUME IN ONE SECOND AND BODY MASS INDEX IN PATIENTS WITH COPD, DURING THERAPY FOR CONTROLLING THE DISEASE(Macedonian Academy of Sciences and Arts, 2009); Stevcevska G.Abstract: Patients with chronic obstructive pulmonary disease (COPD) are characterized by an impaired lung function and limited exercise tolerance. Medication and rehabilitation programmes are generally directed towards relief of symptoms and improvement of lung function and exercise tolerance. 130 patients were included in the examination with diagnosed chronic obstructtive pulmonary disease, stable form, 114 male and 16 female, of whom 121 were smokers and 9 were non-smokers. Inclusive criteria were FEV1 < 50% from predicted (with moderate and severe level of the disease), the relation FEV1/FVC < 70%, the test of reversibility with β2-agonist < 15%. The patients were followed up for 18 months. They were evaluated at the start, and then at the end of the study. During the examination 9 patients were excluded because they did not obey recommendations of the examination, and three patients died during the examination. At the end of our study 77 patients in group I, 66 male and 11 female, were evaluated, and 41 patients, 35 male and 6 female, in group II. The patients were divided on the basis of BMI (body mass index), group I with BMI from 21 to 28 kg/m2 and group II with BMI < 21 kg/m2 . The mean age of the patients was 63 ± 7.2 years in group I, and 68 ± 8.3 in group II. The values of FEV1 at the start were 1.33 ± 0.35L (43 ± 8.1%) in group I, and 0.89 ± 0.27 L (28 ± 7.9%) in group II. Both were significantly lower in group II (p < 0.001). At the end of the study the values of FEV1 were lower in both groups than at the start (Fig. 1). At the start of the study SGRQ scores in group I were significantly lower (p < 0.001) than in group II. This indicated a better quality of life in patients with BMI from 21 to 28 kg/m2 . The SGRQ scores at the end of the study were also significantly lower in group I (p < 0.001). And they were lower than at the start in both groups, indicating a better quality of life in patients with COPD after18 months’ regular use of therapy (Fig. 2). The values of Pearson’s coefficient r = -0.49 (p < 0.05) in group I and r = -0.35 (0.05) in group II, shows that between these two variables there is an indirect, or negative correlation; lower values of FEV1 are associated with higher SGRQ total scores. It can be concluded that regular use of therapy for controlling the disease leads to improved quality of life in COPD patients, which is not associated with improvement in lung function. Patients with malnutrition (BMI < 21kg/m2 ) have lower values of FEV1, and they have higher SGRQ scores of quality of life. High levels of SGRQ scores are associated with lower values of FEV1. Key words: COPD, therapy, quality of life, forced expiratory volume in one second, body mass index.