Faculty of Medicine

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    The influence of illness duration before diagnosis on clinical characteristics and outcome in human brucellosis
    (SAGE Publications, 2019-05-06)
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    Siskova, Dijana
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    Vidinic, Ivan
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    Our study assesses the influence of illness duration before establishing the diagnosis of brucellosis and initiating therapy on patients’ main clinical characteristics and outcome in an endemic area. The medical files of 297 patients with brucellosis were retrospectively analysed. They were divided into four groups according to illness duration before initiating therapy: <10 days; 11–30 days; 31–90 days; and >90 days. There were significant differences in the occurrences of fever (P = 0.019), focal forms (P = 0.026), spondylitis (P = 0.034) and therapeutic failures (P = 0.006) between the groups. Duration of >30 days before treatment initiation is responsible for more serious clinical presentation and outcome, whereas illness duration of >90 days further worsens the clinical progression in human brucellosis.
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    Myocardial Infarction in Systemic Lupus Erythematosus - the Sex Specific Risk Profile
    (Bentham Science Publishers Ltd., 2020-12-09)
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    Pop-Gjorceva, Daniela
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    Accelerated atherosclerosis is widely present in patients with systemic lupus erythematosus.
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    Identification of risk factors for lethal outcome in patients with severe community-acquired pneumonia
    (Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2020)
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    Denkovska E
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    Aim of the study. To determine clinical and biochemical parameters as risk factors for mortality in patients with severe community-acquired pneumonia. Material and methods. A prospective, parallel group analysis of patients with community-acquired pneumonia, treated at the Intensive Care Unit of the University Clinic for Infectious Diseases in period of one year. A total of 42 adults (>=18 years) were enrolled, who were divides in two groups according to the outcome; survived and deceased. The outcome was defined as survival or death during the 30-day hospital treatment. Demographic, clinical as well as laboratory parameters were evaluated in all patients on admission. A statistically significant finding was considered if p<0,05. Results: The average age of patients was 61+15.2 years, and 33 (78.6%) were males. The overall mortality was 50%. In 29 (69%) patients a comorbid condition was registered, and comorbidity showed a statistical significance regarding the outcome. All had tachycardia, tachypnea and hypotension on admission, but impaired consciousnesses and shock were associated with mortality. Patients who died had a higher leukocyte count (15.9+11.8x109/L), higher procalcitonin levels (43.9+77.3 mg/ml), higher serum glucose levels (11.4+6.2 mmol/L) and lower PaO2/Fi O2 (122.64+ 52.8). Hyperglycaemia and hypoxia were the biochemical parameters that showed a statistically significant difference between the two study groups. Conclusion: Early identification of the risk factors for lethal outcome in patients with severe community acquired pneumonia enables implementation of adequate therapeutic measures, thereby decreasing the mortality in this group of critically ill patients.