Faculty of Medicine

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    Metabolic Syndrome and Myocardial Infarction in Women
    (Bentham Science Publishers, 2021-04-29)
    Djuro Macut
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    Sanja Ognjanovic
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    Milka Ašanin
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    Gordana Krljanac
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    Abstract: Metabolic syndrome (MetS) represents a cluster of metabolic disorders that arise from insulin resis-tance (IR) and adipose tissue dysfunction. As a consequence, there is an increased risk for type 2 diabetes melli-tus and atherosclerotic cardiovascular disease (CVD). MetS is associated with a 2-fold increase in cardiovascu-lar outcomes. Earlier population analyses showed a lower prevalence of MetS in women (23.9%) in comparisonto men (27.8%), while later analyses suggest significantly reduced difference due to an increase in the preva-lence in women aged between 20 and 39. However, the prevalence of MetS in specific populations of women,such as in women with polycystic ovary syndrome, ranges from 16% to almost 50% in some geographical re-gions. Abdominal fat accumulation and IR syndrome are recognized as the most important factors in the patho-genesis of MetS. After menopause, a decline in insulin sensitivity corresponds to an increase in fat mass, circu-lating fatty acids, low-density lipoproteins, and triglycerides. Prevalence of MetS in acute coronary syndrome(ACS) is significantly more present in women (55.9%-66.3%) than in men (40.2%-47.3%) in different cohorts.Younger women with ACS had a higher mortality rate than younger men. Acute myocardial infarction (AMI)remains a leading cause of death in aging women. Women with AMI had significantly higher rates of prior con-gestive heart failure, hypertension history, and diabetes. The role of androgens in CVD pathogenesis in womenhas not yet been clarified. The current review aims to provide an insight into the role of MetS components andinflammation for the development of atherosclerosis, CVD, and AMI in women.
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    Anxiety in acute myocardial infarction survivors
    (SHMSHM / AAMD, 2020)
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    Sevime Sallahi Pasholli
    Introduction :Data obtained in some studies indicate that somatic disorders, in a certain percentage, are associated with a mental health problems, whether in a form of two co-existent diseases, whether psychological problems are only associated symptoms and/or response to somatic disease. Anxiety is psychological symptoms frequently encountered in patients suffering from acute myocardial infarct (AMI). The AIM of our study was to determine the percentage of anxiety in two investigated groups of patients with myocardial infarction and to determinate the correlation between socio-demographic characteristic and level of anxiety in survivors of AMI. Material and methods: The study was designed as observation cross-section including 80 patients treated at the university Clinic of Cardiology Skopje , observed as 2 groups : group 1 was presented with patients during hospitalization for AMI, and 2 group were patients survivors after 6 months of the acute coronary event. Anxiety status was assessed using HAMA scale. Results : The two groups of patients did not show significant difference according distribution of gender , smoking , physical activity, stress , age, mean HAMA , BMI , age of education and marital status . In the first group 21 (51,2%) of patients have anxiety symptoms while in second group 25 (64,1%). In our study acute MI was more prevalent in a men but women had a higher risk of anxiety disorders 27,3% v.s (22,7%). In examination groups the anxiety (HAMA score) was positive correlate with socio-demographic and clinical parameters where only we got negative correlate between anxiety with marital status and BMI in the first group and negative correlation with married status, smoking status, physical activity, stress and BMI in the second group . .Conclusion: The results in our study showed indicative representation of anxiety in patients survivors of AMI. So screening for anxiety in all AMI patients is also important because this patients should be treated differently than those who are not anxiety.
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    Myocardial Infarction in Systemic Lupus Erythematosus - the Sex Specific Risk Profile
    (Bentham Science Publishers Ltd., 2020-12-09)
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    Pop-Gjorceva, Daniela
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    Accelerated atherosclerosis is widely present in patients with systemic lupus erythematosus.