Faculty of Medicine

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    CHARACTERIZING FOOD, DAIRY, AND BEVERAGE AVAILABILITY IN PRIMARY SCHOOL PREMISES IN NORTH MACEDONIA - COSI STUDY
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024-07)
    Mihajlova, Katerina
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    Wallace, Lorraine
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    Introduction: Childhood obesity remains a global public health challenge. Aim: Using WHO COSI-6th round data, the aim of this study was to depict availability of select foods, dairy and beverages in a nationally representative sample of primary schools across North Macedonia. Material and methods: Data were drawn from the WHO COSI-6th round conducted in North Macedonia in 2022. A designated official (n=111) at the respective primary school reported availability of the following: (1) food (fruits, vegetables, ice cream, sweet snacks, and savory snacks), (2) dairy (milk, yogurt, and/or ayran), (3) beverages without added sugar (water, tea, and fruit juices), and (4) beverages with added sugar (non-carbonated fruit juices, carbonated drinks, hot drinks [e.g., cocoa], and flavored milk). Additionally, the designated school official reported whether their primary school had a canteen and/or shop/cafeteria where foods or beverages could be purchased. Results: Across primary schools in North Macedonia, availability of healthy options (i.e., fruits and vegetables) was lower as compared to energy-dense selections (i.e., sweet and savory snacks). Overall, 18.3% of schools offered dairy products (including milk, yogurt, and ayran). Water was the most commonly available (69.0%) beverage. No significant differences emerged in availability of food, dairy, beverages without added sugar or beverages with added sugar across primary school enrollment (small versus large). Less than one-fifth of primary schools had a canteen (17.4%) and/or shop/cafeteria (14.4%) where foods or beverages could be purchased. Conclusion: In conclusion, access to food, dairy, and beverages for primary school children in North Macedonia was limited.
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    Physical treatment of posttraumatic elbow contractures in children – our experience
    (Scientific Foundation SPIROSKI, 2022-03)
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    The most common complications of elbow trauma are contractures and neurovascular injuries. The complications can be a result of the initial injury, but they can also be a result of a surgical treatment. In addition to orthopedic treatment of elbow fractures, physical therapy and rehabilitation play a significant role in treatment of posttraumatic contractures. To determine the effects of physical therapy and rehabilitation of posttraumatic elbow contractures in children. This was a retrospective cross-sectional study conducted in the University Clinic for Physical Medicine and Rehabilitation, Skopje in the period 01.01.2021 – 01.07.2022. A total of 52 children were included, at the age between 2 and 13 years who had a posttraumatic elbow contracture, limited range of motion, pain and/or limitations in accomplishing daily activities. Depending on the clinical finding, children underwent a relevant physical therapy (kinesitherapy, functional therapy, electrotherapy, thermotherapy, hydrotherapy and magnetotherapy) in duration of three weeks. For assessing the effects of the rehabilitation therapy, the range of motion of the elbow and forearm was examined along with the Flynn’s scale in all children, prior to and after completion of the physical treatment. Applied physical treatment resulted in a significant improvement in all analyzed movements such as: elbow flexion (p=0.00001), elbow extension (p=0.00001), forearm pronation (p=0.00001), forearm supination (p=0.0000) and Flynn’s scale (p=0.0000). After completion of the rehabilitation treatment, excellent results were registered in 41 (85%) children, moderate in 10 (19.23%) and favorable in 1 (1.92%). Timely and adequate application of physical therapy and rehabilitation can significantly improve the final outcome in treatment of posttraumatic elbow contractures in children. A combination of different physical procedures adequately applied and personalized can significantly improve the range of motion of the elbow.
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    TUBERCULOUS LYMPHADENITIS IN CHILDREN –14 YEARS OF EXPERIENCE
    (Macedonian Association of Anatomists, 2023)
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    Ivanovska, Julija
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    Nestorov, Hristijan
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    Popova, Gorica
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    Petlichkovska, Sandra
    Tuberculosis (TB)is a major public health problem worldwide. It is one of the main causes of infectious disease and mortality, especially in developing countries. Extra pulmonary tuberculosis accounts for 15-20 % of all types of tuberculosis. Lymph nodes are the second most common localization after pleural TB. In childhood, the most commonly envolved are the hilar lymph nodes. Material and methods: We analyzed the frequency of tuberculous lymphadenitis in children treated at the Institute for respiratory diseses in children-Kozle, in the last 14 years. From January 2006 to February 2020 , we’ve treated 397 children with TB. 55 of them (13,8%), were with tuberculous lymphadenitis. Female children were 34 (61%), the others were male.The most frequent was hilar lymphadenitis at 40 (72%), second localization were cervical lymph nodes in 10( 18%). There was 1 child with submandibular localization,1 supraclavicular, 2children with axillary lymphadenitis and one with mesenterial lymphadenitis. Most of the patients had contact with TB. The diagnosis was confirmed pathohistological in the patients with peripheral lymphadenitis. Tuberculosis treatment was started in all patients based on clinical criteria, exposure, positive TST, chest X-ray, or histological confirmation. All of the patients have finished the treatment successfully. Tuberculous lymphadenitis can be a diagnostic and therapeutic challenge in children. Early diagnosis and timely initiation of therapy lead to favorable therapeutic outcome and reduce complications.
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    SEVERE POST-COVID-19 MULTISYSTEM INFLAMMATORY SYNDROME IN 15-YEAR-OLD GIRL - case report
    (University Ss. Cyril and Methodius in Skopje, 2021)
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    Maja Mojsovska Mijovska
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    Amela Muminovic
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    Sasho Popovski
    In contrast to adults, SARS –CoV-2 mostly leads to a mild illness in children typically manifested with fever, cough and gastrointestinal symptoms. The phenomenon of multisystem inflammatory syndrome in children (MIS-C) emerged during the coronavirus disease 2019 (COVID-19) pandemic. Children with MIS-C have current or recent exposure to the disease. Reported symptoms include fever or chills, tachycardia, gastrointestinal symptoms, rash, conjunctival injection and mucosal changes with a relative lack of severe respiratory disease. We report a related case of a 15-year-old girl with signs and symptoms of MIS-C and respiratory failure. Multisystem inflammatory syndrome in children (MIDS-C) with respiratory failure is a serious life-threatening condition that requires treatment in an intensive care unit. Invasive mechanical ventilation, invasive monitoring and treatment with combination therapy of antibiotics, corticosteroids, inotropic support, analgosedation, anticoagulation therapy and other lead to successful cure.
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    MAIN NEEDS AND CHALLENGES OF PARENTS OF CHILDREN WITH AUTISM SPECTRUM DISORDER
    (Македонска академија на науките и уметностите, Одделение за медицински науки = Macedonian Academy of Sciences and Arts, Section of Medical Sciences/Sciendo, 2020)
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    Pop-Jordanova Nada
    Autism spectrum disorder (ASD) comprises a group of complex lifelong neurodevelopmental disorders, characterized with symptoms related to the difficulty of communication and interaction with other peo ple, as well as restricted interests and repetitive behaviors. These symptoms affects the person’s ability to function properly in school, work, and other areas of life. For better understanding the needs and challenges of families the survey developed by Autism Speaks in collaboration with the National Coordinators for Autism from nine Balkan countries was established. The aim of this research is to obtain an overview of some important data for children with some form of autistic disorder. The same questionnaire was used in two different periods of time (during 2015 and at the beginning of 2020) including samples of 60 and 140 parents respectively. The questionnaire comprises 57 questions in the following four domains: demographic characteristics, index child characteristics, service encounters and parent/caregiver perceptions. Results are compared and discussed. The survey results underscore that parents and families of children with ASD in our country carry a heavy burden. They face significant financial difficulties and need improved services from the health, educational and social sectors. It was concluded that there is a critical need to strengthen national capacity in caring for children, young people and adults with ASD and other neurodevelopmental disorders
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    Evaluation of pediatric patients with juvenile idiopathic arthritis treated with biological therapy tocilizumab (actemra)
    (Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2021-10-06)
    Neshkovska Shumenkovska Marija
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    Gjurkova-Angelovska Beti
    Juvenile idiopathic arthritis (JIA) is the most common chronic disease in childhood. It manifests a heterogenic group of symptoms of arthritis, lasting at least 6 weeks and it appears before the age of 16. Patients who had no good therapeutic response to conventional therapy with Methotrexate were treated with biological therapy. The aim of this paper was to evaluate 9 patients who were receiving Tocilizumab at the Department of Rheumocariology, University Clinic of Pediatric Diseases in Skopje. Materials and methods: Our study included 9 patients treated at our Department with biological therapy with Tocilizumab. Prior to initiation of the biological therapy, all patients underwent laboratory investigations, purified protein derivate (PPD) skin test for tuberculosis, X ray of the lungs and heart, and analysis of hepatitis markers. All patients were treated with amp. Actemra( Tocilizumab) 8mg/kg /tt i.v. Two of the patients had a severe form of the disease (one with severe systemic form and one with severe oligoarticular form of JIA). All presented patients had clinical remission of the disease. Conclusion: Therapy with tocilizumab in patients with juvenile idiopathic arthritis is a good therapeutic choice. The results obtained in our study have shown a significant therapeutic effect of tocilizumab even in severe forms of the disease
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    CORRELATION BETWEEN TONSIL HYPERTROPHY AND ALLERGIC RHINITIS IN CHILDREN
    (Macedonian Association of Anatomists, 2020-12-25)
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    Dukovska, Vesna
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    Nikoloska, Sofija
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    To show whether there is a correlation between the tonsils hypertrophy and adenoid hypertrophy (AH) with allergic rhinitis in children in R. Macedonia. A total of 120 children (5.3 ± 1.2 years old)with tonsil hypertrophy, adenoid hypertrophy, persistent upper respiratory infections and consecutive nasal obstruction were examined, after their parents gave a verbal consent for their participation. Inclusion criteria were: frequent upper respiratory infections, angina, nasal congestion due to nasal obstruction caused by adenoid hypertrophy, frequent serous otitis due to adenoid hypertrophy and sleep apnea due to tonsil hypertrophy.The prevalence of allergic rhinitis (AR) was as follows: AR had 70% of children with concha nasal hypertrophy, 39.2% of children with tonsillar hypertrophy, and 78.3% of children with adenoid hypertrophy. Although in the group of children with adenoid hypertrophy, a more severe degree of nasal concha hypertrophy was registered in children with AR compared to children without AR, itwasstatistically not significant.Regarding children with adenoid hypertrophy (AH), the results showed that children with AR presented significantly different results for Parikh's scale (p = 0.0076). Obstruction of torus tubarius was more common in children with AR (86.8% vs. 61.2%), while these children had a finding of soft palate obstruction (9.4% vs.26.8%), and vomer obstruction (3.8% vs.11.9%) less often than children without AR.Our study found that almost half of the children with tonsillitis/adenoid hypertrophy hadAR. Grade 3 and 4 TH was present in third of the children.
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    Anthropometric parameters and indexes in 9 year-old-children from R. North Macedonia
    (Macedonian Association of Anatomists, 2021-04-02)
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    The aim of the study was the detection of sex-specific differences of anthropometric parameters and indexes that were used as indicators of growth and nutritional status in the 9-year-old-children from R.North Macedonia.The study included 280 healthy children aged 9 (140 boys, 140 girls) from R.North Macedonia. Fourteen anthropometric parameters were measured which define longitudinal, circular and transversal measures of skeleton using standard equipment and measurement technique. The following indicators were calculated: weight-for-age (BW), height-for-age (BH), BMI, mid-upper circumference-for-age (MUAC) and skinfolds thickness (scapula SFSc and triceps SFTr)-for-age.The results have shown significant sex-specific differences in favour of boys for the height, four transversal and three circular parameters, with exception of mid-upper-arm circumference and skinfolds that were apparently higer in girls. Values of the 50th percentile in boys were as follows: 33 kg for BW, 136 cm for BH and 17.65 kg/m2 for BMI, 19.8 cm for MUAC and for skinfolds: SFSc 8 mm and 12 mm for SFTr.The values of these parameters in girls were: 32 kg for BW, 135cm for BH and 17.47 kg/m 2 for BMI. 20.8 cm for MUAC and for SFSc 9.8 mm and 12.8 mm for SFTr .These results can be used as criteria for the assessment of the morphological characteristics and detection of deviations in the growth and nutritional status in children aged 9.
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    OSTEOMYELITIS OF FEMUR IN A DRUG ADDICTED CHILD
    (Macedonian Association of Anatomists, 2021)
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    One of the serious complicationsrelated to intravenous drug use is osteomyelitis. We report a13-year-old male child with a history of intravenous heroin abuse, who was admitted to the hospital complaining of abdominal pain and pain in the left leg. Anteroposterior roentgenogram and CT scan of the left thigh and femur,confirmed the diagnosis of osteomyelitis. Pus culture was positive for Staphylococcus aureus. Despite extensive antibiotic and anticoagulant therapy,the patient’sclinical status improved very slowly. Surgical procedure was not undertaken. Femoral osteomyelitis due to injection drug use in childhood is an extremely rare and uncommoncondition. Intravenous drug abuse, late-onset treatment, and secondary bacterial infection can lead to complications which occurred in the case presented.Itis an extremely difficult condition to treat and is a real challenge for physicians. The rapid response and participation of a multidisciplinary team of physiciansis of particularimportance
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    Temporal trends in asthma and asthma-like symptom prevalence in Skopje, The Republic of Macedonia
    (European Respiratory Soc Journals LTD, 2016-09)
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    Kimovska, Mica
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    Seckova, Lidija
    Background: There have been differences in temporal trends of asthma prevalence by geographic region. It is important to consider local patterns to plan health care. The aim of this study was to assess temporal trends in asthma prevalence among young adolescents in Skopje, Republic of Macedonia as a developing country. Methods: Data was obtained from 3 cross-sectional surveys (2002, 2006 and 2015) of adolescents (12-15 years) from randomly selected schools in Skopje. Trends in the prevalence of asthma and asthma-like symptoms were investigated descriptively and using multiple logistic regression to adjust for potential confounders. Results: The prevalence of asthma increased although the changes were not statistically significant (2002: 1.7%; 2006: 2.1%; 2015: 2.6%; p=0.13). The prevalence of ever wheeze differed by year (2002: 18.4%; 2006: 15.3%; 2015: 26.4%; p<0.001). Statistically significant (p<0.05) reductions in wheeze prevalence over time (2002, 2006 and 2015) were observed for current wheeze (8.8%, 7.2% and 5.9%), exercise-induced wheeze (14.2%, 7.9% and 2.1%), and night cough (16.5%, 13.6% and 10.2%). After adjustment for potential confounders, there was an increase in asthma likelihood by year compared to 2002 (2006: OR=1.35, 95%CI=0.74-2.44; 2015: OR=2.12, 95%CI=1.04-4.35). In the adjusted analyses, associations between year and the asthma-like symptoms confirmed the descriptive results. Conclusion: A significant decrease in asthma symptoms contrary to a slight increase in asthma diagnosis in Skopje during a period of 13 years was established. Improved diagnostics and treatment may explain some of these changes.