Faculty of Medicine

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    Item type:Publication,
    OSTEOMYELITIS OF FEMUR IN A DRUG ADDICTED CHILD
    (Macedonian Association of Anatomists, 2021)
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    One of the serious complicationsrelated to intravenous drug use is osteomyelitis. We report a13-year-old male child with a history of intravenous heroin abuse, who was admitted to the hospital complaining of abdominal pain and pain in the left leg. Anteroposterior roentgenogram and CT scan of the left thigh and femur,confirmed the diagnosis of osteomyelitis. Pus culture was positive for Staphylococcus aureus. Despite extensive antibiotic and anticoagulant therapy,the patient’sclinical status improved very slowly. Surgical procedure was not undertaken. Femoral osteomyelitis due to injection drug use in childhood is an extremely rare and uncommoncondition. Intravenous drug abuse, late-onset treatment, and secondary bacterial infection can lead to complications which occurred in the case presented.Itis an extremely difficult condition to treat and is a real challenge for physicians. The rapid response and participation of a multidisciplinary team of physiciansis of particularimportance
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    Antibiotics use in relation to asthma in children
    (Wiley Blackwell, 2018-05)
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    Kimovska, M
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    Seckova, L
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    Background: Early-life antibiotic exposures have been reported to increase the risk of allergic diseases. The aim of the study was to examine the impact of current antibiotics use on asthma in schoolchildren in The Republic of Macedonia, as developing country with a high rate of antibiotics use and low prevalence of asthma. Method: Data from 2310 schoolchildren aged 5-15 years obtained through a parental-completed questionnaire in randomly selected primary schools in Skopje, the capital of Macedonia, in 2015/2016 was used. The frequency of antibiotics intake ≥3 and <3 times yearly vs never antibiotics intake for respiratory infections, in the last 12 months was correlated to current asthma-like symptoms and ever-diagnosed asthma after adjustment for confounding factors using multiple logistic regression. Results: 50.9% of the children used antibiotics currently and 21.0% out of them used antibiotics ≥3 times yearly. Current wheeze (W) was established in 6.5%, sleep-disturbing W in 3.6%, exercised-induced W in 1.7%, dry night cough apart from a cold in 12.2% and asthma in 2.3%. Current antibiotics use ≥3 times yearly was positively associated with current W (aOR: 13.37; 6.14-29.11; p < 0.001), sleep-disturbing W (aOR: 7.87; 3.34-18.57; p < 0.002), dry night cough (aOR: 3.80; 2.29-6.29; p <0.001), and diagnosed asthma (aOR: 5.68; 1.96-16.50; p = 0.001) while antibiotics use <3 times yearly was positively associated only with current W (p = 0.003) and dry night cough (p = 0.011). Conclusion: The results suggest an aggravating role of antibiotics use on asthma in school age thus further supporting the recommended restriction of antibiotics exposure.