(Macedonian Society of Nephrology, Dialysis, Transplantation and Artifical Organs, Department of Nephrology, 2021) ; ; ; ;
Focal segmental glomerulosclerosis
(FSGS) is defined as an increase in the mesangial matrix
in some glomeruli with obliteration of capillary lumens,
sclerosis, hyalinosis, foam cells, and adhesions to the
Bowman’s capsule. Collapsing glomerulopathy is a
morphologic variant of focal segmental glomerulosclerosis (FSGS) characterized by segmental and global
collapse of the glomerular capillaries, marked hypertrophy and hyperplasia of podocytes, and severe tubulointerstitial disease. Actually secondary collapsing glomerulopathy is a heterogeneous group including numerous causes: viruses, toxins and drugs such as heroin
and pamidronate
