Faculty of Medicine
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Item type:Publication, Systemic inflammatory profile in patients with chronic obstructive pulmonary disease(Macedonian Association of Anatomists and Morphologists, 2024-05-01); ; ; Chronic obstructive pulmonary disease(COPD)is heterogeneous condition with various phenotypes that have their own pathogenetic mechanisms and certain inflammatory mediators, as C-reactive protein, interleukins, circulating leukocytes. Uncovering the inflammatory profile may identify disease biomarkers. We aimedto compare the values of systemic inflammatory parameters in patients with different clinical phenotypes and determine their correlation with clinical parameters.In 30 COPD patients weanalyzeddemographic and clinical data, history of allergies, cigarette smoking and history of exacerbations. We phenotyped them intonon-exacerbator, exacerbator and COPD with asthma phenotype. COPD assessment test, modified dyspnea scale and the BODE (Body mass index, Obstruction, Dyspnea, Exercise capacity) index werecalculated. Spirometry and lung X-ray were performed. Peripheral blood was taken for analysis of inflammatory parameters.There were 16 patients(53.33%) with phenotype of non-exacerbator, and 7 (23.33%) with exacerbatorand COPD with asthma phenotype each. COPD assessment testhadsignificantly lowestvalue in non-exacerbator and modified dyspnea scalesignificantly highest value in exacerbatorphenotype. Therewere no mild gradepatientsin exacerbator,andno very severe grade in nonexacerbatorphenotype. C-reactive proteinand interleukin 8 had significantly lowest value in non-exacerbator; leucocytes significantly highest value in exacerbator; eosinophyls and interleukin 4 significantly highest value in COPD with asthma phenotype. There was no significant difference among the three phenotypes in neutrophyls andinterleukin 18. The three clinical phenotypes: non-exacerbator, exacerbator and COPDwith asthma have their own specific clinical and inflammatory features that have clinical, prognostic and therapeutic implications - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Strengthening Clinician-Researchers' Communication and Knowledge Translation Skills: An Innovative Game Model From the Breathe Well Group(Sage Publishing, 2024-09-12) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Metabolic Syndrome (MetS) as a comorbidity of Chronic Obstructive Pulmonary Disease (COPD)(European Respiratory Society, 2021-09-05); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, QUALITY OF LIFE, FORCED EXPIRATORY VOLUME IN ONE SECOND AND BODY MASS INDEX IN PATIENTS WITH COPD, DURING THERAPY FOR CONTROLLING THE DISEASE(Macedonian Academy of Sciences and Arts, 2009); Stevcevska G.Abstract: Patients with chronic obstructive pulmonary disease (COPD) are characterized by an impaired lung function and limited exercise tolerance. Medication and rehabilitation programmes are generally directed towards relief of symptoms and improvement of lung function and exercise tolerance. 130 patients were included in the examination with diagnosed chronic obstructtive pulmonary disease, stable form, 114 male and 16 female, of whom 121 were smokers and 9 were non-smokers. Inclusive criteria were FEV1 < 50% from predicted (with moderate and severe level of the disease), the relation FEV1/FVC < 70%, the test of reversibility with β2-agonist < 15%. The patients were followed up for 18 months. They were evaluated at the start, and then at the end of the study. During the examination 9 patients were excluded because they did not obey recommendations of the examination, and three patients died during the examination. At the end of our study 77 patients in group I, 66 male and 11 female, were evaluated, and 41 patients, 35 male and 6 female, in group II. The patients were divided on the basis of BMI (body mass index), group I with BMI from 21 to 28 kg/m2 and group II with BMI < 21 kg/m2 . The mean age of the patients was 63 ± 7.2 years in group I, and 68 ± 8.3 in group II. The values of FEV1 at the start were 1.33 ± 0.35L (43 ± 8.1%) in group I, and 0.89 ± 0.27 L (28 ± 7.9%) in group II. Both were significantly lower in group II (p < 0.001). At the end of the study the values of FEV1 were lower in both groups than at the start (Fig. 1). At the start of the study SGRQ scores in group I were significantly lower (p < 0.001) than in group II. This indicated a better quality of life in patients with BMI from 21 to 28 kg/m2 . The SGRQ scores at the end of the study were also significantly lower in group I (p < 0.001). And they were lower than at the start in both groups, indicating a better quality of life in patients with COPD after18 months’ regular use of therapy (Fig. 2). The values of Pearson’s coefficient r = -0.49 (p < 0.05) in group I and r = -0.35 (0.05) in group II, shows that between these two variables there is an indirect, or negative correlation; lower values of FEV1 are associated with higher SGRQ total scores. It can be concluded that regular use of therapy for controlling the disease leads to improved quality of life in COPD patients, which is not associated with improvement in lung function. Patients with malnutrition (BMI < 21kg/m2 ) have lower values of FEV1, and they have higher SGRQ scores of quality of life. High levels of SGRQ scores are associated with lower values of FEV1. Key words: COPD, therapy, quality of life, forced expiratory volume in one second, body mass index. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COMBINED SPINAL-EPIDURAL ANESTHESIA FOR ABDOMINAL HYSTERECTOMY IN PATIENTS WITH COPD(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, 2017-04); ; ;