Faculty of Medicine
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Item type:Publication, Evaluation of the surgical treatment of lung cancer(European Respiratory Society, 2024-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Our experiences in the surgical approach to the treatment of lung cancer(Peytchinski Publishing Ltd, Pleven, Bulgaria, 2024); ; ; It is considered that 2,200,000 new patients with lung cancer are detected annually in the world (Globcan 2020), i.e. 1,135 in the Republic of North Macedonia (Globcan 2020), of which only 59 patients were surgically treated at the thoracic and vascular surgery clinic in 2022, which is 85% of the total surgically treated in the Republic of North Macedonia. The use of oncological drugs before surgical treatment can contribute to the application of surgery in cases where it was not possible, as well as reduce the tumor so that a less extensive surgical procedure can be applied. At the Thoracic and Vascular Surgery Clinic, of 59 patients surgically treated for lung cancer, 49 (83%) were treated with open anterolateral thoracotomy, and lobectomy with lymphadenectomy was most commonly performed in 41 (49.5%). Early diagnosis of lung cancer, using computed tomography screening, would allow the use of less aggressive approaches, such as videothoracoscopic surgery, robot-assisted surgery, and the use of less extensive lung resections such as segmentectomies with lymphadenectomy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Modalities of surgical approach in the treatment of lung cancer(MIT University Skopje, 2024-03); ; ; ; Lung cancer is the most common malignancy in men and in the entire human population. It is considered that 2,200,000 new patients are detected annually in the world (Globcan 2020), i.e. 1,135 in the Republic of North Macedonia (Globcan 2020), of which only 59 patients were surgically treated at the thoracic and vascular surgery clinic in 2022, which is 85% of the total surgically treated in the Republic of North Macedonia.1 Numerous surgical techniques of lung resections are at our disposal in the treatment of lung malignancy, from wedge resection, segmentectomy, lobectomy and pneumectomy, which depends on the stage of the disease, localization of the tumor, involvement of other structures, functional reserves, etc. Lobectomy with lymphadenectomy is still a standard surgical technique in the treatment of early lung cancer (stage I and II non-small cell cancer). The use of oncological drugs before surgical treatment can contribute to the application of surgery in cases where it was not possible, as well as reduce the tumor so that a less extensive surgical procedure can be applied. At the Thoracic and Vascular Surgery Clinic, of 59 patients surgically treated for lung cancer, 49 (83%) were treated with open anterolateral thoracotomy, and lobectomy with lymphadenectomy was most commonly performed in 41 (49.5%).Early diagnosis of lung cancer, using computed tomography screening, would allow the use of less aggressive approaches, such as videothoracoscopic surgery, robot-assisted surgery, and the use of less extensive lung resections such as segmentectomies with lymphadenectomy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of the surgical treatment of lung cancer(Department of Anaesthesia and Reanimation, Faculty of Medicine, "Ss. Cyril and Methodius " University, Skopje, R.N. Macedonia, 2024-03); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Genetic Alteration Profiling in North Macedonian Lung Cancer Patients(MDPI AG, 2025-10-10); ; ; ; Background/Objectives: Late diagnosis and inefficient treatment regimens lead to poor prognosis, with a low 5-year survival rate for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). New targeted therapeutic agents can be developed and introduced only by first discovering new driver oncogenes and with a thorough investigation of the known driver genes. The aim of the current study is to investigate the prevalence of alterations in the eight most frequently altered genes in lung cancer-BRAF, EGFR, KRAS, ALK, ROS1, HER2, PD-L1 and PIK3CA. Methods: Real-time polymerase chain reaction (RT-PCR) was used to detect KRAS and EGFR mutations, multiplex PCR and microarray hybridization for KRAS/BRAF/PIK3CA mutations. Immunohistochemical analysis was performed for the detection of ALK, HER2/NEU, ROS-1 and PD-L1 alterations. Results: Overall, 221/603 patients (36.65%) had at least one genetic alteration, of which 22 patients (3.65%) had two genetic alterations and two patients had more than two genetic alterations. Additionally, 50 patients were identified with one or more KRAS mutations (8.29%), 45 patients with EGFR mutations (7.46%), and 1.82% with PIK3CA mutations and 0.66% with BRAF mutations. Furthermore, 50% of the co-occurring alterations were either on KRAS and PIK3CA genes (3/6), on KRAS and BRAF genes (2/6, 33.33%) or on EGFR and PIK3CA genes (1/6, 16.67%), and 10.45% of the patients exhibited PD-L1 overexpression, 5.31% ALK rearrangements, and 2.36% HER2/NEU expression, with no ROS-1 rearrangements detected. Conclusions: Comprehensive testing for somatic alterations in EGFR, BRAF, KRAS, and PIK3CA is significant in guiding therapeutic decisions in lung cancer management. Such testing should be routinely conducted to establish a thorough genetic profile of lung cancers in a manner that is both time-efficient and cost-effective. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BRAIN METASTASIS FROM LUNG CANCER(Македонско лекарско друштво = Macedonian medical association, 2025-04); ; Lung cancer is the leading cause of global cancer incidence and mortality, accounting for 2,4 million new cases and 1,8 million deaths in 2022. The most common symptoms of lung cancer include persistent cough, hemoptysis, weight loss, chest pain and dyspnea. One of the most common metastatic sites of lung cancer is the brain, with intracranial involvement in approximately 20% of patients at the time of diagnosis, and although rare the initial presentation of the disease can derive from this site. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SMOKING HABIT AS A RISK FACTOR ASSOCIATED WITH OCCURRENCE OF LUNG CANCER(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024-07); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SOCIO-DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF LUNG CANCER PATIENTS IN NORTH MACEDONIA(Macedonian Association of Anatomists, 2024-04); ; Nehteparova, MelihaLung cancer disease is one of the most common causes of mortality in the world, coming right after cardiovascular diseases. It is a big and is a special problem in the highly developed countries, especially in the USA, but also in developing countries. The reason for the research is the fact that the number of newly diagnosed and death cases from lung cancer is constantly growing, especially in the last few years. The aim of the study is to determine the influence of socio-demographic factors in the occurrence of lung cancer(gender, age, national and ethnic origin, place of residence) and smoking as the main risk factor associated with this neoplasm. The research is a descriptive study in which 82 patients with pathohistological confirmed lung cancer participated. It was implemented at the Institute for Oncology and Radiotherapy at the clinical center in Skopje for a period of 3 months. A total of 82 patients were registered from Institute for Oncology and Radiotherapy in Skopje, North Macedonia who were diagnosed with primary lung cancer. Of all, 64.7% of them were males and 35.3% were females. Histologically, 51.2% had adenocarcinoma, 25.6 had squamous cell carcinoma, 20.7% had small cell carcinoma and 7.4% had no small cell carcinoma. It was observed that the proportion of females diagnosed with primary lung cancer is increasing. Patients get diagnosed at a later stage of the disease, which calls for screening and early detection of lung cancer.