Faculty of Medicine
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Item type:Publication, Divestment–Adventitia Resection in Order to Decrease Morbidity and Mortality and Improve R0/R1 Ratio in Curative Pancreatoduodenectomy for Advanced Pancreatic Head Carcinoma(Scientific Foundation Spiroski (publications), 2026-06-14); ; ; Kolari, ArbijonAbstract BACKGROUND: Pancreatic head carcinoma (PHC) is a highly aggressive malignancy associated with substantial morbidity, mortality, and poor long-term survival. Achieving an R0 resection margin during pancreatoduodenectomy (PD) is crucial for improving oncological outcomes. However, in borderline resectable (BRPHC) and locally advanced pancreatic head carcinoma (LAPHC), arterial involvement often necessitates complex arterial resections associated with high perioperative risks. Periarterial sub-adventitial divestment has emerged as a potential alternative to arterial resection, aiming to improve radicality while reducing complications. AIM: To evaluate whether sub-adventitial arterial divestment during curative pancreatoduodenectomy decreases perioperative morbidity and mortality and improves the R0/R1 resection ratio in patients with BRPHC and LAPHC. METHODS: A retrospective study was conducted on 50 consecutive patients with BRPHC or LAPHC treated between 2009 and 2017 following neoadjuvant therapy when indicated. All patients underwent extensive pancreatoduodenectomy with triangle operation, extended lymphadenectomy, and periarterial sub-adventitial divestment of the superior mesenteric, common hepatic, and/or celiac arteries. Clinicopathological data, perioperative morbidity, mortality, length of hospital stay, and R0/R1 resection status were analyzed. RESULTS: Among the 50 patients, 27 (54%) were male and 23 (46%) were female, with a mean age of 63.1 ± 8.97 years. Overall mortality was 8% (4/50). Major complications included postoperative pancreatic fistula (24%), postoperative biliary fistula (2%), postpancreatectomy hemorrhage (4%), reoperation (6%), necrotizing pancreatitis (4%), thromboembolism (4%), cardiac failure (2%), and pulmonary complications (8%). Venous resection was required in 12% of patients. Postoperative pain relief was achieved in 92% of cases. Mean hospital stay was 10.56 ± 6.09 days. Histopathological examination demonstrated R0 resection in 28 patients (56%) and R1 resection in 22 patients (44%). Morbidity and mortality rates were comparable to standard PD and appeared lower than those reported for PD combined with arterial resection. CONCLUSION: Sub-adventitial arterial divestment during pancreatoduodenectomy is a feasible and safe technique for selected patients with borderline resectable and locally advanced pancreatic head carcinoma. The procedure provides acceptable morbidity and mortality rates while achieving favorable R0 resection outcomes, representing a promising alternative to arterial resection in specialized high-volume centers. Keywords Pancreatic head carcinoma Pancreatoduodenectomy Arterial divestment Borderline resectable pancreatic cancer R0 resection - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE MESORECTUM AND MESORECTAL FASCIA – A TOPOGRAPHIC-ANATOMICAL OVERVIEW(Serbian Anatomical Society (Српско анатомско друштво – САДС), 2026-09-24); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VERTEBRAL LEVEL OF ORIGIN OF THE ANTERIOR BRANCHES OF THE ABDOMINAL AORTA IN A CT ANGIOGRAPHIC STUDY(Serbian Anatomical Society (Српско анатомско друштво – САДС), 2026-09-24); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SEXUAL DIMORPHISM OF DERMATOGLYPHIC PATTERNS IN NORTH MACEDONIA(Comenius University Bratislava, 2026-09-10); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The role of rapid chromatographic immunoassay tests in acute poisoning: two case reports and literature overview(Edizioni Minerva Medica, 2026-03-22); ; ; ; This report through the presentation of two case studies highlights the common problem with false-positive urine drug screen faced by many physicians to the emergency and toxicology departments. Case 1: a 29-year-old male patient was admitted after acute poisoning with analgesics/antipyretics (Caffetin Cold, Caffetin); diazepam; amlopin. Case 2: a 56-year-old female patient was admitted with impaired consciousness. According to the data obtained from the patient’s family they suspected that she took the following drugs: Zanfexa, Zalasta and Diazepam. A rapid chromatographic immunoassay urine test was performed in both patients for the following substances: opiates, amphetamines, metamphetamine, MDMA (3,4-methylenedioxymethamphetamine), oxycodone, phencyclidine, cocaine, methadone, barbiturates, cannabinoids, benzodiazepines, tricyclic antidepressants, and tramadol. Case 1 was positive for opiates, benzodiazepines and amphetamines. Gas chromatography mass spectrometry and high-performance liquid chromatography were used and confirmed the presence of caffeine, codeine, paracetamol, propyphenazone, pseudoephedrine, dextromethorphan, nordazepam, ramipril and amlodipine in urine sample. Case 2 was positive for tramadol and benzodiazepines. Gas chromatography mass spectrometry was used and confirmed the presence of venlafaxine, its metabolites and nordazepam in serum and urine samples. If a false-positive urine screen result is suspected, nonimmunologic techniques, such as gas chromatography/mass spectrometry or high-performance liquid chromatography, are necessary for confirmation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Late emergence of myasthenia gravis complicating envenoming by Vipera ammodytes(Elsevier BV, 2026-10-01); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of the C-Reactive Protein to HDL Cholesterol Ratio as a Marker of Cardiovascular and Renal Risk Among Type 2 Diabetic Patients(Galenos Publishing House, 2026-08-27); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANATOMICAL FEATURES OF THE VERTEBROBASILAR SYSTEM AND CLINICAL SIGNIFICANCE(Serbian Anatomical Society = Српско анатомско друштво – САДС, 2026-09-24) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Education for Radiological Technologists and Their Place in Mammography Diagnostic Methods(Egitim Danismanligi ve Arastirmalari (EDAM), 2015-05-10) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Morphological and Functional Changes in Schoolchildren with Bad Posture(Scientific Scholar, 2016-12)