Faculty of Medicine

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    KОUNIS SYNDROME - A CASE REPORT OF ACUTE MYOCARDIAL INFARCTION AFTER BEE BITE
    (MIT University, 2024)
    Petreski, Mario
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    CHRONIC RESPIRATORY SYMPTOMS AND SPIROMETRIC PARAMETERS AMONG PROFESSIONAL DRIVERS - THE IMPACT OF OCCUPATIONAL EXPOSURE AND WORK TENURE
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2026-06-18)
    Andonov, Goran
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    Aim. To assess the prevalence of chronic respiratory symptoms, spirometric parameters and the effects of occupational exposure among professional drivers. Material and methods. A cross-sectional epidemiological study was conducted including 70 male professional drivers and 70 administrative staff matched by age, work tenure, occupational exposure and smoking status. Data on respiratory symptoms, smoking status, occupational exposure to harmful agents and work tenure were collected using a standardized questionnaire. Spirometry was performed to assess lung function. Results. Professional drivers had a significantly higher prevalence of respiratory symptoms compared to controls, including any respiratory symptom (81.4% vs. 58.6%, p=0.003), nasal symptoms (35.7% vs. 8.6%, p<0.001), cough (61.4% vs 34.3%, p=0.002), cough with phlegm (37.1% vs. 20.0%, p=0.040), dyspnea (31.4% vs. 17.1%, p=0.049) and wheezing (25.7% vs. 7.1%, p=0.006). All spirometric parameters were significantly lower in drivers, indicating involvement of both large and small airways (p<0.05). Drivers with ≥ 20 years of work tenure exhibited a significantly higher prevalence of symptoms and lower spirometric values. Multivariable logistic regression identified exposure to gases as the strongest independent predictor of respiratory symptoms (adjusted OR up to 12.4, p<0.01), followed by exposure to smoke (adjusted OR up to 6.31, p<0.05). Dust exposure showed a non-significant trend, while vapors were not associated with respiratory symptoms. Conclusion. Professional drivers are at increased risk of developing respiratory symptoms and lung function impairment compared to the control group. Occupational exposure to gases and smoke represents the main independent risk factor, while longer work tenure suggests a cumulative adverse effect.
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    Non-ampullary mucinous adenocarcinoma of the small intestine unmasked by persistent anemia: A Case Report
    (Liga-Inform, Ltd., 2026-02-23)
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    Jankoski, D.
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    Kutanoski, D.
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    Kostovska Irena
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    Perforatedsolitarymid-rectaldiverticulumdiagnosedwith colonoscopy:acasereportandliterature review
    (Oxford University Press (OUP), 2026-01-27)
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    Avramoski, Vladimir
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    Gjinoska, Klaudia
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    Kostovska, Irena
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    Stoicovski, Emil
    Rectal diverticulum is an exceedingly rare clinical entity, typically occurring as a solitary lesion or, less frequently, as up to three diverticula. Its development is often associated with underlying conditions such as obstructive defecation syndrome, rectal malignancy, pelvic floor weakness, chronic rectal impaction, obesity, or infection-related muscular atrophy. Although uncommon, rectal diverticulitis represents a surgical emergency requiring timely recognition and management. In this case, a female patient presented with rectal bleeding and secondary anemia. During the clinical course, the patient developed pelvic sepsis secondary to rectal diverticulitis. Appropriate surgical intervention, combined with antimicrobial therapy and supportive management, led to a favorable outcome. Rectal diverticulitis is a rare but potentially life-threatening condition. Awareness of this entity and early diagnosis are essential to prevent severe complications such as perforation and pelvic sepsis. This case highlights the importance of considering rectal diverticulum in the differential diagnosis of lower gastrointestinal bleeding and pelvic infections.
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    Antihypertensive Medication Use and Biochemical Outcomes in Primary Care Patients: A Multicenter Study in Kosovo
    (Oriental Scientific Publishing Company, 2026-03-20)
    Alidema, Fitim
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    Kostovska, Irena
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    Alidema, Arieta Hasani
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    Mustafa, Lirim
    Arterial hypertension remains a major public health challenge that requires longterm pharmacological management; however, antihypertensive therapy may also be associated with metabolic and biochemical alterations. This multicenter retrospective study evaluated the association between antihypertensive drug use and biochemical parameters among primary care patients in Kosovo and compared outcomes across three healthcare centers (Prishtina, Ferizaj, and Gjilan). A total of 900 patients with essential hypertension receiving continuous treatment for at least 12 months were included. Data were extracted from medical records and laboratory registers between January 2024 and January 2025 and comprised demographic variables, treatment regimens (monotherapy or combination therapy), and biochemical parameters, including lipid profile, fasting glucose, renal markers, and electrolytes. Statistical analyses included ANOVA or Kruskal–Wallis tests, chi-square tests, correlation analysis, and multivariate logistic regression. Combination therapy was associated with significantly higher levels of LDL cholesterol, triglycerides, and creatinine compared to monotherapy (p < 0.05), while lipid alterations were more prominent among patients treated with beta-blockers and diuretics (p < 0.01). The use of two or more antihypertensive drug classes independently predicted an increased risk of dyslipidemia (OR 1.8, 95% CI: 1.2–2.5; p = 0.004). No significant differences were observed in glucose levels between the study centers (p = 0.21). Long-term antihypertensive therapy, particularly polytherapy, is associated with clinically relevant biochemical changes affecting lipid metabolism and renal function, highlighting the necessity for routine laboratory monitoring and individualized treatment optimization in primary care practice.
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    CONSERVATIVE TREATMENT OF A CHRONIC WOUND WITH HYDROFIBER DRESSINGS: A CASE REPORT
    (Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2026-06-19)
    Mihajloski, Vladimir
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    Volchevski, Goce
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    Ognjenovikj, Ljubomir
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    MULTIPLI VENTRICULAR SEPTAL DEFECTS – A CASE REPORT
    (MIT University, 2025)
    Trajchevska Margarita
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    Zaku Vegim
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