Faculty of Medicine
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Item type:Publication, TREATMENT OF UNSTABLE FOREARM FRACTURES WITH ELASTIC INTRAMEDULLARY OSTEOSYNTHESIS IN CHILDREN(Association of Albanian Medical Doctors in Macedonia, 2018) ;Todorovich L. ;Kamilovski M.; ; Lumani Nj.Introduction: Over the past years there has been a marked increase in the use of intramedullary fixation in the management of displaced forearm fractures in children. This reflects high incidents of redisplacement, malunion and functional limitations. Aim: This retrospective study was performed to analyze the functional results of the elastic intramedullary titanium nail fixation used in the treatment of unstable, diaphyseal forearm fractures in children. Material and methods: From March 2013 to March 2012, 235 patients with forearm fractures were treated at our institution. Percutaneous intramedullary f ixation with titanium nail was performed in 132 patients, 96 with unstable reposition and 36 with redislocation 48 hours after the injury. The mean age of the patients was 9.6 (5-13) years. In 34 patients (31%) limited open approach to one or both was necessary for reduction. Result: In 12 patients we encountered minor complications. The average union time was 7.5 (5-13) weeks. We rated the functional results using the Price grading scheme. Thirty-two patients obtained excellent results, four very good, four good and two scored poorly. Conclusion: Despite the minor complications, percutaneous intramedullary fixation with titanium nails is an appropriate and safe treatment method for unstable fractures of the forearm in children which cannot be treated by closed manipulation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTHROPOMETRICAL INDEXES AS NUTRITIONAL INDICATORS IN CHILDREN(EUROPEAN ASSOCIATION OF CLINICAL ANATOMY (EACA), 2019); ; ; ; Introduction:. In order to prevent and reduce the increasing trend of obesity, anthropometric variables of growth and nutritional status in children have to be constantly monitored.The aim of our study was evaluation of sex-specific differences of anthropometrical indexes that were used as indicators for assessment of nutritional status in children aged 8. Examinees and methods: The study included 212 healthy children (106 boys, 106 girls) aged 8 from Macedonian nationality. With standard methodology (IBP) were taken following body measurements (body weight, height, mid upper arm circumferences-MUAC and skinfolds thickness triceps–SFTr and subscapular-SFSc), and according to standard formulas were calculated: weight-for-age (BW), height-for-age (BH), body mass index-for-age (BMI), mid upper arm circumferences-for age (MUAC), and skinfolds thicknes-for-age (SFTr and SFSc). Results: Results showed sex-specific differences in a large number of the examined anthropometrical parameters (BW, BH, BMI) in favour of the boys. On the other hand, skinfolds thickness (SFTr and SFSc) were significantly higher in girls. Values of the 50th percentile in boys were as follows:30 kg for BW,131 cm for BH, 17.3 kg/m2 for BMI, 18cm for MUAC, 5.5 mm for SFSc, and 8.6mm for SFTr. The values of these parameters in girls were: 29 kg for BW,129.2. cm for BH,16.8 kg/m2 for BMI, 18.5cm for MUAC, 6.9 mm for SFSc and 10.2 for SFTr. Conclusions: These results can be used as criteria for the assessment and detection of deviations in the nutritional status in children aged 8. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Utility of exhaled nitric oxide in pediatric practice-review of literature.(Macedonian Association of Anatomists and Morphologists, 2019); ; ; ; Popova, GoricaThe field of interest for measurement of exhaled nitric oxide (NO) and nasal NO is significantly evolving over the last 25 years, with over 1000 publications published in that area. Inflammation of the airways is a central process in asthma and other lung disorders, but the monitoring of the inflammation has not been included in the current recommendations. The exhaled air contains volatile media such as nitric monoxide, carbon monoxide, ethane, pentane and non-volatile substances in the liquid phase in the exhalation, as a condensate (hydrogen peroxide). It is increasingly confirmed that the measurement of exhaled mediators in general, and especially NO, is a new way to monitor certain aspects of asthma, COPD and interstitial lung disease, which cannot be estimated with other methods, like lung function. In asthma, exhaled NO is recommended to be used as a marker for diagnosis, for monitoring the response of anti-inflammatory drugs, confirming the safety of therapy and predicting asthma exacerbation. Measurements of FeNO are easily performed, they are reproducible and technically less expensive than the analysis of induced sputum. In symptomatic patients, high FeNO levels (> 50 ppb), refer to significant eosinophilia in the airways, which will most likely respond to treatment with ICS. The current data provides support for the diagnostic use of FeNO in children with symptoms of asthma. For patients with chronic and/or severe asthma, FeNO levels are useful for determining whether eosinophilic inflammation of the airways is active or not. Both high (> 50ppb) and low (<25 ppb) levels of FeNO can be used to for predicting the outcome in patients with a definitive history of asthma who are currently in remission and who have stopped treatment with ICS. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Role of Quantiferon TB gold test in diagnosis of latent tuberculosis infection(LTBI) in childhood and its correlation with tuberculin skin test(Macedonian Association of Anatomists and Morphologists, 2015); ; ;Petrusevska Kolekevska, Lidija ;Dilberovska, MirjanaDacevski, DraganTuberculosis is a significant health problem among children population worldwide. Timely diagnosis and treatment of the disease are the basis for prevention of its further spreading. However, the diagnosis of latent tuberculosis infection is a challenge because there is no gold standard. The aim of this study was to evaluate the importance of the diagnostic Quantiferon TB gold test in the diagnosis of latent TB infection and to correlate it with Tuberculin skin test according to the Mantoux method. For the realization of this study we analyzed 32 patients examined for possible M. tuberculosis infection at the Institute of Respiratory Diseases in Children, Kozle, Skopje. The study included 16 girls and 16 boys, aged 9 months to 17 years, with an average age of 6.96 ± 4.49 years. In all children basic biochemical analyses were made: аcid-alcohol-resistant bacilli in a direct sample of sputum, Levenstein Jensen cultures, chest X-ray, tuberculin skin test according to the Mantoux method and Quantiferon TB gold test. The results showed that 24 patients had a BCG scar. All participants in this study had normal radiographic findings of the lungs. In 4 cases Quantiferon TB gold test was positive, while in 28 patients the test was negative. Tuberculin skin test was positive in 13 subjects. In children with negative Quantiferon TB gold test LTBI was excluded and drug prevention with Isoniazid was not started or it was interrupted. Determination of IFN-γ contributes to better diagnosis of LTBI and in reducing the unnecessary drug use. Using Quantiferon TB gold test may be an alternative tool for Tuberculin skin test in the diagnosis of tuberculosis in countries where vaccination with BCG is widespread. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison od IFN-γ levels in children with tuberculosis desease(TB) and latent tuberculosis infection (LTBI).(ID Design Press,Skopje, Republic of Macedonia, 2018-11-25); ; ;Simonovska, Liljana ;Dilberovska, MirjanaDacevski, DraganAIM: This study aimed to evaluate the importance of IFN-γ in the diagnosis of pediatric TB and LTBI and to compare the IFN-γ levels. METHODS: We analysed 100 patients examined for possible M. tuberculosis infection or disease at the Institute of Respiratory Diseases in Children, Kozle, Skopje. Patients were divided into 2 groups: TB disease and LTBI. The following parameters were analyzed: demographic characteristics, history of previous exposure to active TB, BCG vaccination and presence of BCG scar, lung X-ray findings, tuberculin skin test by the Monteux method and the value of INF-γ according to the Quantiferon TB gold test, direct samples of acid-alcohol-resistant bacilli of sputum and Löwenstein Jensen cultures. Informed parental consent was obtained for each child included in the study. RESULTS: In the LTBI group 60.9% had a scar from the vaccination while in the TB group 50% had BCG scar. TST induration diameters in children with or without BCG scar were significantly larger in patients with active TB. Children with active TB had significantly higher IFN-γ levels than children with LTBI. The IFN-γ for the cut-off of 0.35 IU/ml, has 64% sensitivity for detection of LTBI, versus 80.6% sensitivity for active disease. Children with close TB contact had significantly higher IFN-γ levels. Correlation between TST induration diameter and IFN-γ levels was stronger in the TB group. CONCLUSION: IFN-γ levels are significantly higher in children with active TB, and children with close contact with TB patient. It has better sensitivity in active TB. Using both tests (IFN-γ and TST) can improve the diagnose of LTBI and TB in countries where vaccination with BCG is widespread. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Health risk assessment of air pollution in Skopje(2017-11-02); ;P.Simjanoski ;Sh. Musa ;V. DobrosavljevikjLj. KostadinovskiIntroduction: It is estimated that three million people die every year from air pollution, which indicates the importance of daily concentrations of substances that are deposited in ambient air as a consequence of stationary or mobile sources of pollution leading to the occurrence of non-specific respiratory disease. Aim: To show the health effects of air pollution in order to promote awareness of its reduction as a significant risk to the environment and human health. Review of pre-school and school age from non-specific respiratory diseases and reduction of the number of diseased children based on the performed monitoring of ambient air quality. Material and Methods: The data are obtained from the Annual Report prepared for the implementation of the National Annual Public Health Program for 2015 at the Public Health Center in Skopje, which monitors seasonal morbidity from non-specific respiratory diseases in pre-school (0-6) and school children (7-14), especially for town and village after the codes J00-J99 (non-specific respiratory diseases) with the exception of J10-J18 (influenza and pneumonia), the International Classification of Diseases (ICD-10) from the Annual reports that follow the quarterly air pollution and impact on human health for the period 2012-2016. Results: From the evaluation of the data, it can be concluded that the children from the village are less affected than the city, as well as the existence of a cyclic seasonal variation of morbidity. Conclusion: The assessment of the risk of hygienic air quality on the health of the exposed population in the case of pre-school and school children is done on the basis of the received data from the performed monitor, which points to a higher pollution rate in the city than in the village. It is necessary to monitor the air quality by monitoring the continuous measurement of the measuring points and taking a sample to determine the concentration of the air pollutant. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Psychological impact of chronic kidney disease on children(2018)A large number of children are suffering from chronic diseases. Like most chronic childhood illnesses, chronic kidney disease (CKD) deeply affects child's life, both physically and emotionally, concerning that they experience a lot of stress, have many responsibilities with disease management, face possibility of the shortened life span and questionable quality of life. Moreover, CKD would affect the family and siblings too. Many factors influence on proper psychosocial adjustment. Most often it depends on age of the disease’s onset, clinical features, family structure and functioning, child’s age and personality, supporting system etc. Majority of the children with CKD will easily express physical unease, but many of them will hide how they mentally feel. As well as medical treatment, psychological coping and recovery is an important part of managing CKD too. Fear and anxiety are most common emotions. They address health, future, medical procedures especially dialysis or kidney transplantation, uncertainty in the family, school and social life. Depressive feelings, hopelessness or despair can also seriously interrupt the medical treatment and overall child’s health. Denial is present especially when the trauma is very severe and threatens child’s wellbeing. Anger is also common. Child can be mad about what is happening to him/her, mad at parents and medical community for allowing their health to deteriorate, mad to “higher powers” or destiny. Furthermore, impairment of cognitive functions occurs frequently in CKD too. It can be seen in the areas of attention, cognitive flexibility, executive functioning, memory and learning, which can deeply affect child’s everyday functioning or performance in school. Treating children with CKD needs a multidisciplinary care. Early identification and treatment of psychological conditions is very important, in order to improve child’s quality of life as well as his/her family. Children with CKD live longer, so understanding long-term psychosocial effects becomes increasingly important to clinicians and families. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Psychometric and Neurophysiological Assessment of School Children with Attention Deficit Hyperactivity Disorder-Toward Better Management and Treatment(SHMSHM / AAMD, 2017) ;Pop-Jordanova NADHD represents a big problem in the educational process because these children are not able to be attentive, patient, to seat quietly during the class, and additionally they have learning difficulties. In the past decade researchers became more involved in defining and evaluating executive functions in children manifesting Attention Deficit Hyperactivity Disorder (ADHD). Executive functions are involving information from the working memory, inhibition of the inappropriate behavior, as well as directing and sustaining the attention, towards a goal-oriented behavior. The aim of this article is to show our results obtained from psychometric and neuropsychological evaluation of the executive functions in a group of school children diagnosed as ADHD, as well as results for neurofeedback training we used therapeutically. The evaluated group is composed of 50 ADHD children and 20 healthy children as a control, matched by age and gender. Neurophysiological assessment was performed with Visual Continuous Performance Test (VCPT) from which Event Related Potentials were extracted. Psychological assessment comprised the use of Stroop Color Word Task (SCWT) and Wisconsin Card Sorting Test (WCST), while mothers fulfilled Child Behavior Check List (CBCL) and ADD-H: Comprehensive Parent Rating Scale (ACTeRS). Obtained results from psychological and neurophysiological assessment confirmed the diagnosis of ADHD as well as a presence of serious difficulties in executive system functioning trough ERP’s component extracted from QEEG analysis. As a used nonpharmacological therapeutic approach we accentuated very positive outcome of neurofeedback treatment of these children. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EVALUATION OF SEX-SPECIFIC DIFFERENCES OF ANTHROPOMETRIC PARAMETERS OF GROWTH IN 9 -YEAR-OLD MACEDONIAN CHILDREN FROMURBANAREA(Macedonian Association of Anatomists and Morphologists, 2014); ; ; ; Aim: Evaluation of sex-specific differences of anthropometric parameters that were used as indicators for growth in children at the age of 9 years. Subjects and methods: The study included 225 healthy children aged 9 years from Macedonian nationality and urban area. Fourteen anthropometric parameters were measured that define longitudinal, circular and transversal parameters of the skeleton using standard equipment and measurement technique. The following indicators were calculated: weight-for-age [BW], height-for-age [BH] and BMI. Results: The majority of anthropometric parameters showed no significant sex-specific differences, with exception of diameter of wrist, and circumferences of head, chest, and upper-arm, which were significant in favour of boys. Values of the 50th percentile in boys were as follows: 34.4kg for BW, 136.7 cm for BH and 18.25 kg/m2 for BMI. The values of these parameters in girls were: 32.25 kg for BW, 133.05cm for BH and 18 kg/m2 for BMI. Conclusions: These results can be used as criteria for the assessment of the anthropometric characteristics and detection of deviations in growth and nutritional status in 9-year-old children. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Idiopathic pulmonary hemosiderosis; a retrospective study from a pediatric hematology-oncology center(European Hematology Association, 2011); ; ;O. MuratovskaS. Glamocanin
