Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
86 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report)(Scientific Foundation Spiroski (publications), 2016-12-06); ; BACKGROUND: Goodpasture syndrome was originally described as an association of alveolar haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys healthy body tissue. AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and glomerulonephritis, which is diagnosed by renal biopsy. CASE PRESENTATION: His illnessbegan a year and a half before being diagnosed. In that period he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was 8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was: Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was diagnosed with Goodpasture syndrome. He received corticosteroid therapy and cyclophosphamide, with good response to treatment, and he is currently in a stable condition, receiving only corticosteroid therapy. CONCLUSION: Goodpasture syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damage to renal and pulmonary function. With current therapy, long-term survival is more than 50%. Keywords: alveolar haemorrhage, glomerulonephritis, immune system, anti-glomerular basement membrane (anti-GBM) antibodies, Goodpasture syndrome - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The occurrence of acute subdural haematoma and diffuse axonal injury as two typical acceleration injuries(Elsevier, 2012); ; ; ; Popevska, ZClosed head injuries have already been classified into contact injuries and acceleration–deceleration injuries. Two typical acceleration–deceleration injuries and at the same time, the two worst head injuries are acute subdural haematoma (ASDH) and diffuse axonal injury (DAI), and that is where they got their medico-legal importance. Using experiments, it has been shown that acceleration with an impact time of more than 20–25 min (which occurs in traffic accidents in real life) causes DAI, whereas an impact time of 5–10 min is more likely to produce acute subdural haematoma. The aim of this research is to show that not all, but some types of traffic accidents are more typical for the occurrence of DAI, as well as that the ASDH is not a common feature for all types of fall. The analysis conveyed covered 80 cases of closed head injuries (traffic accidents, falls and assaults) where a complete forensic medical autopsy has been undertaken, followed by a complete forensic–neuropathological examination. For the purpose of diagnosing DAI, immunohistochemistry using antibody against β-amyloid precursor protein has been involved. Results show that ASDH is more likely to occur in cases of simple fall, assaults and cyclists and DAI is more typical for vehicular traffic accidents and cases of falling from a considerable height. The paper also comprises discussion about some open questions regarding the diagnosis of DAI in the medico-legal practice. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dilemmas concerning the diffuse axonal injury as a clinicopathological entity in forensic medical practice(Elsevier, 2012); ; ; ; Popevska, ZDilemmas and discussions concerning the diffuse axonal injury (DAI) and still existing in forensic medical practice are as it follows: 1. Whether the occurrence of DAI can indicate the type of traumatic event that has caused the head trauma, 2. Whether the presence of axonal damage in cases of hypoxia, ischaemia and other pathological conditions casts a shadow on the post-mortem pathological diagnosis of DAI and totally negates it, or there are certain clues in the findings that can point to the aetiology of the axonal damage. This paper discusses our findings based on neuropathological examination of 60 forensic cases of closed head injury. The neuropathological examination included: a macroscopic examination of the coronal sections and a microscopic examination involving an immunohistochemical method with antibody against β-amyloid precursor protein. Our findings indicate that DAI, as a clinicopathological entity, is undoubtedly an acceleration–deceleration injury, predominant in road traffic accidents as it is classically outlined, and cases of falling from a considerable height. Our findings point to a certain difference between the features of traumatic and ischaemic axonal damage. In this paper we also investigate the correlation between pathological grades of DAI and the impairment of the brain function before death. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative analysis of effect of metoprolol and remifentanyl on mean arterial pressure in general anaesthesia(Medical faculty, Ss Cyril and Methodius University in Skopje, 2017) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison of adductor canal block with femoral nerve block in anterior cruciate ligament reconstruction(Association of Physiologists of Macedonia, 2018) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Validation of the ELISA Method for Quantitative Detection of TNF-α in Patients with Intracerebral Hemorrhage(Scientific Foundation SPIROSKI, 2017-09); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Review of patients with diabetes in Macedonia(Scientific association of endocrinologist and diabetologist of Macedonia, 2014); ; I. Ahmeti - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Case report of patient with mixed medullary-papilary carcinoma of thyroid gland(Scientific association of endocrinologist and diabetologist of Macedonia, 2018-05); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, One-year retrospective study of hospitalized patients on parenteral bisphosphonate therapy at Univ.Kl. for Endocrinology, Diabetes and Metabolic Disorders, Skopje, Republic of Northern Macedonia.(2019-04);