Faculty of Medicine
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Item type:Publication, Impaired glucose tolerance in obese children and adolescents(Blackwell Munksgaard, 2008); ; Sukarova Angelovska, Elena - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, P094 Relationship between microbiological isolates from sputum and age of cystic fibrosis patients in the Cystic Fibrosis Centre at the Institute for Respiratory Diseases in Children in Skopje, the Republic of Macedonia(Elsevier BV, 2019-06); ; ; Gjinovska Tasevska, Elena - Some of the metrics are blocked by yourconsent settings
Item type:Publication, P330 Clinical effects of probiotic supplementation in patients with cystic fibrosis in the Republic of Macedonia(Elsevier BV, 2019-06); ; Gjinovska Tasevska, Elena - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, The association of C3435T single-nucleotide polymorphism, Pgp-glycoprotein gene expression levels and carbamazepine maintenance dose in patients with epilepsy.(Dove Medical Press, 2012); ; ; ; The ABCB1 gene encodes the P-glycoprotein (Pgp) protein, which is thought to transport various antiepileptic drugs. The single nucleotide polymorphism (SNP) (C3435T) in exon 26 of this gene correlates with the altered expression levels of P-glycoprotein, range of drug response and clinical conditions. In order to investigate the influence of this polymorphism on the susceptibility to and efficacy of carbamazepine therapy, we evaluated the allelic frequency and genotype distribution of this variant in 162 epilepsy patients from the Republic of Macedonia. Statistically significant differences were detected neither in the allelic frequency and genotype distribution between carbamazepine-resistant and carbamazepine-responsive epilepsy patients nor between the subgroups of carbamazepine (CBZ)-responsive patients treated with different CBZ doses. However, the T-allele was enriched in CBZ-responsive patients who required higher maintenance CBZ doses, This observation was substantiated by the findings that the median total plasma levels were the lowest in patients with CC (20 μmol/L) followed by CT (23 μmol/L) and TT (29 μmol/L) genotypes. Patients with a CC genotype also had a higher likelihood of response compared to patients with CT or TT genotypes over a wide range (400-1000 mg/day) of initial doses of CBZ. The T allele showed a reduced expression of ~5% compared to the C allele in peripheral blood mononuclear cells in heterozygotes for the variant. This difference might be translated into ~10% difference in homozygotes for the variant, which would explain the trend towards a dose-dependent efficacy of the CBZ treatment in patients with different genotypes. A larger prospective study is warranted to clarify the clinical utility of a genotypespecific individualized CBZ therapy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Declining malformation rates with changed antiepileptic drug prescribing: An observational study.(Wolters Kluwer (American Academy of Neurology), 2019-08) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Promotion of exercise to children and young people - mechanisms of action(European Federation of Sports Medicine Associations, 2019); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidental prostate cancer in patients undergoing radical cystoprostatectomy in treatment for bladder cancer: our five-year results(SHMSHM - AAMD, 2013); ; ; The aim of the paper was to verify the incidence and features of incidental prostate cancer in patients who underwent radical cystoprostatectomy for invasive bladder cancer. Methods and results: A total of 96 patients underwent radical cystoprostatectomy between January 2006 and December 2010 in the University Clinic of Urology in Skopje. 10 patients were excluded for incomplete data. The average age of the study group was 61.2 years (range 32-78). Prostate cancer was found in 10 (11.6%) cases. Seven patients were clinically insignificant. Conclusion: Incidentally diagnosed prostate cancer was frequently insignificant. Digital rectal examination and prostate specific antigen should be part of the diagnostic procedure in patients who undergo cystoprostatectomy. Standard RCP which include removal of bladder with prostate gland and seminal vesicles is safer for radicality and prevention of residual prostate cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Management of primary bladder tumors at the University Clinic of Urology in Skopje in 2010 during one-year follow up.(2016);