Faculty of Medicine

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1977 - 197921980 - 19896

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End date: 1989

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    Treatment of hirsutism with Cyproteron acetate
    (Македонско лекарско друштво = Macedonian medical association, 1989)
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    Петровски, Кирил
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    Богоев, Милчо
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    Димитровски, Чедо
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    Complete atrio-ventricular block in childhood
    (1977)
    Zdraveva, M
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    Doneva, V
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    Sadikario, A
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    Osteopetrosis in infancy
    (1977)
    M Delidzakova
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    T Nikolova
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    N Grivceva
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    A Gordova
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    R Dzarlieva
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    Translocation between chromosomes 1 and 9 in childhood acute lymphoblastic leukemia
    (ELSEVIER SCIENCE INC, 1986-03-01)
    Ohyashiki, K
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    Ohyashiki, J H
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    Ryan, D H
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    Rowe, J M
    A case of a non-T, non-B acute lymphoblastic leukemia with a translocation between chromosomes #1 and #9 is described. The breakpoints in these chromosomes were determined to be at bands 1q23 and 9p22, respectively. The breakpoint in chromosome #1 was at the same site as that in a subgroup of acute lymphoblastic leukemia with t(1;19), and the breakpoint in #9 was the same as that in t(9;11)(p22;q23) in acute monoblastic leukemia. We discuss the possible association between these chromosome bands (1q23, 9p22, 11q23, and 19p13) and the morphologic features of the leukemic cells. The breakpoint in chromosome band 1q23 may be specifically associated with acute lymphoblastic leukemia.
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    Secondary acute myeloblastic leukemia with a Ph translocation in a treated Wegener's granulomatosis
    (ELSEVIER SCIENCE INC, 1986-01-15)
    Ohyashiki, K
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    Ryan, D H
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    Rowe, J M
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    Sandberg, A A
    Ph-positive acute myeloblastic leukemia (AML) developing in a treated case of Wegener's granulomatosis is reported. The patient was a 70-year-old white male who received cyclophosphamide (150 mg/day) starting in July 1978; in May 1984 the patient was diagnosed as having AML, following a diagnosis of myelodysplastic syndrome lasting 3 months. Cytogenetic study of bone marrow cells at the diagnosis of the myelodysplastic syndrome revealed a standard Ph translocation in addition to numerical chromosome changes [i.e., 45,XY, -5, -7, -8, +19, +mar/45,XY, -5, -7, -8, +19, +mar,t(9;22)(q34;q11]). The events in this case suggest a strong possibility of the Ph-positive AML being a secondary disease related to prior cyclophosphamide therapy.
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    Major karyotypic abnormalities in a near-tetraploid erythroleukemia
    (1985-06)
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    Sandberg, A A
    A case of erythroleukemia (EL; FAB M6) is presented in which the leukemic cells of the marrow were characterized by two ranges in the chromosome number, i.e., one hypodiploid and another near-tetraploid. All characteristics of major karyotypic abnormalities (MAKA) were present, i.e., increased karyotype instability with variation of the chromosome count from metaphase to metaphase, dicentrics, acentrics, marker chromosomes, double minute chromosomes (DMs), and centromere spreading. All of these events were variably represented from metaphase to metaphase. The prognosis was poor, with survival of 1 month after the diagnosis of EL. The meaning of extreme MAKA in the classification of EL is discussed.
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    Translocation 4;11 acute leukemia: three case reports and review of the literature
    (Elsevier BV, 1985-03-01)
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    Kowalczyk, J R
    ;
    Sandberg, A A
    Three children with acute leukemia and t(4;11)(q21;q23) are presented. Two of the cases showed very unusual karyotypic findings and long survival for the type of leukemia. In case B.T., the original karyotype change observed was t(4;11), with other changes (+4q-,+11q+,+6,+10) appearing during the last stages of the disease. In case R.B., the translocation was accompanied by many numerical and morphological chromosome changes, with a near-tetraploid chromosome number. In both of the above cases, remission was associated with a normal marrow karyotype. In case D.C., only the t(4;11) was observed. The number of cases with t(4;11) and acute leukemia published so far is 36, including the three cases presented by us. As this disease is usually characterized by a relatively short survival, the possible reasons for the remarkably long survival in two of our patients are discussed in relation to the rather unusual cytogenetic findings.