Faculty of Medicine
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Item type:Publication, Приказ на случај: Заборавена хируршка газа 14 години.(2006); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Management of primary bladder tumors at the University Clinic of Urology in Skopje in 2010 during one-year follow up.(2016); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE ROLE OF THE EARLY DIAGNOSIS OF AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE IN FETUSES- CASE STUDY(SHMSHM - AAMD, 2018-09); ; ; ; ABSTRACT Introduction: The autosomal recessive polycystic kidney disease (ARPKD) is a rare disorder that is present in 1:20,000 babies. A fetal death may occur due to a severe oligohydramnios, or neonatal death caused by pulmonary insufficiency. The aim of the case study presentation is to point out the importance of the ultrasound diagnosis as early as possible in the pregnancy, so that the right decision is made by the parents and by the gynecologist. Methods: The methods used in this case include ultrasound, invasive diagnosis- amniocentesis and chorionic villus sampling, cytopathologic analysis and PCR amplification and sequencing of PKHD1 gene in the parents’ blood, amniotic fluid and chorionic villi. Results: The patient is 29 years old women, fourth pregnancy, previous two labors on time with caesarean section, both of the babies died in the neonatal period and are subject to post-mortem examination. The findings from the post-mortem examination shown a suspicion for autosomal recessive polycystic kidney disease (ARPKD). After the second result of the post-mortem examination, the parents were examined for having a mutation in the PKHD1 gene and it was confirmed that both of them are having this mutation. The third pregnancy ended with an induced abortion because the amniocentesis confirmed a fetus having a homozygote for ARPKD. In the fourth pregnancy a chorionic villus sampling was performed and a fetus was found with a heterozygote for ARPKD and the pregnancy was successful with a viability of the fetus. Conclusion: The timely intervention of gynecologist can prevent unfavorable effects- Caesarean section of matured fetuses that then usually exist in the first two months, because dialysis is the only therapy, temporarily until kidney transplantation takes place. This leads to emotional and medical consequences suffered by the parents. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prognostic significance of serum levels of tumor markers CEA and CA19-9 in patients with colorectal cancer(Македонско лекарско друштво = Macedonian medical association/De Gruyter, 2012); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, From aneurysmal bone cyst to telangiectatic osteosarcoma with metastasis in inguinal lymph nodes: Case report(National Library of Serbia, 2015); ; ; ; Introduction. Aneurysmal bone cyst is a benign bone lesion composed of blood filled cystic cavities lined by fibrous septa. Its malignant transformation of is a rare event. Case report. We report a case of a lesion in the second metatarsal bone in a 29-year-old male, presented as a slight swelling of the right foot. After the curettage had been done, the diagnosis of aneurysmal bone cyst was made but the recurrence occurred 4 years later. The biopsy of the recurrent tumor showed compact neoplastic tissue consistent with diagnosis of giant cell tumor with malignancy. The malignant component was recognized as a high grade sarcoma with osteoid production. A tumor mass with the whole II metatarsal bone was extirpated and a resected part of fibula was transplanted. A year later, another recurrence occurred, an amputation was performed and a teleangiectatic osteosarcoma with ingvinal lymph nodes metastases was diagnosed. No other tumor mass was confirmed, either clinically or by imaging techniques at the time of his third operation. He died 4 months later with multiple pulmonary metastases. Conclusion. We emphasize the importance of team work in order to achieve the accurate diagnosis, highlighting careful radiological examinations, good sampling and awareness of unusual cases in bone tumor pathology. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer(National Library of Serbia, 2014-01); ; ; ; Matrix metalloproteinases (MMPs) are perceived to play a key role in tumor invasion and metastasis by their capacity to degrade basement membranes and extracellular matrix proteins. The aim of this study was to investigate the expressions of MMP-2, MMP-7 and MMP-9 in tumor tissue and their relation to clinicopathologic features in patients with colorectal cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Serum Matrix Metalloproteinase-2, -7 and -9 (MMP-2, MMP-7, MMP-9) levels as Prognostic Markers in Patients with Colorectal Cancer(University of Sarajevo Faculty of Health Sciences, 2012-12-15); ; ; ; <jats:p>Introduction: Matrix metalloproteinases are produced by tumour cells, hence, they may be associated with tumour progression including invasion, migration, angiogenesis and metastasis. Finding prognostic markers to better identify patients with higher risk for poor survival would be valuable in order to customize pre- and postoperative treatment as well as to enable closer follow-up of these patients. Aim of our study was to examineMMP-2, MMP-7 and MMP-9 serum levels and correlated them with pathological data such as stage of the colorectal cancer (CRC) and outcome.Methods: The investigation included 82 patients with operable CRC without distant metastases, who had underwent blood tests in order to determine the MMP-2, MMP-7 and MMP-9 serum levels in the following time periods: preoperatively, 3, 6, 9 and 12 months postoperatively.Results: The values of the investigated MMPs decrease postoperatively and start to increase 6 month later in patients of all stages of the disease, reaching the highest value 12 month postoperatively with statistically important differences of MMP-2, MMP-7 and MMP-7 serum levels in terms of disease staging and defined points of time. Analysis of the results showed that the MMP-2 serum levels obtained 3 and 12 months postoperatively,than MMP-7 serum levels 12 months postoperatively and the MMP-9 serum levels in all analyzed points in time were in significant association with the CRC patients’outcome.Conclusion: The MMP-2, MMP-7 and especially MMP-9 serum values could be important indicators for diagnosis of the patients with CRC and for monitoring of disease progression.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The importance of the detail forensic-neuropathological examination in the determination of the diffuse brain injuries(2012-01); ; ; According to the contemporary classification, traumatic brain damage is divided on focal and diffuse brain injuries, and primary and secondary brain damage. The aim of this paper is to emphasize the necessity of the forensic-neuropathological examination in the determination of the diffuse brain injuries. In those injuries frequently neither the most sophisticated clinical-investigation techniques like CT and MRI, nor the routine post-mortem forensic pathological examination, give any results with discovering an intracranial mass lesion, despite the fact that patients had manifested a serious brain failure. In a series of 80 cases with closed head injuries where forensic-neuropathological examination has been undertaken (examination of a fixed brain tissue and immunohistochemistry using monoclonal antibodies against β-amyloid precursor protein), the occurrence of the diffuse brain injuries in the absence of any other massive intracranial lesion has been established in 14 (17,7%) of the cases. Hence, forensic-neuropathological examination has been the only way to establish the diagnosis of the brain injury that caused a serious brain failure and in most of them occurred as a concrete cause of death. This method has already been affirmed in the forensic medicine science and has been implemented in a Recommendation No 99 of the Council of Europe where medico-legal autopsy rules are given, thus, establishing it as an unavoidable part of the daily forensic medicine practice. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The occurrence of acute subdural haematoma and diffuse axonal injury as two typical acceleration injuries(Elsevier, 2012); ; ; ; Popevska, ZClosed head injuries have already been classified into contact injuries and acceleration–deceleration injuries. Two typical acceleration–deceleration injuries and at the same time, the two worst head injuries are acute subdural haematoma (ASDH) and diffuse axonal injury (DAI), and that is where they got their medico-legal importance. Using experiments, it has been shown that acceleration with an impact time of more than 20–25 min (which occurs in traffic accidents in real life) causes DAI, whereas an impact time of 5–10 min is more likely to produce acute subdural haematoma. The aim of this research is to show that not all, but some types of traffic accidents are more typical for the occurrence of DAI, as well as that the ASDH is not a common feature for all types of fall. The analysis conveyed covered 80 cases of closed head injuries (traffic accidents, falls and assaults) where a complete forensic medical autopsy has been undertaken, followed by a complete forensic–neuropathological examination. For the purpose of diagnosing DAI, immunohistochemistry using antibody against β-amyloid precursor protein has been involved. Results show that ASDH is more likely to occur in cases of simple fall, assaults and cyclists and DAI is more typical for vehicular traffic accidents and cases of falling from a considerable height. The paper also comprises discussion about some open questions regarding the diagnosis of DAI in the medico-legal practice. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dilemmas concerning the diffuse axonal injury as a clinicopathological entity in forensic medical practice(Elsevier, 2012); ; ; ; Popevska, ZDilemmas and discussions concerning the diffuse axonal injury (DAI) and still existing in forensic medical practice are as it follows: 1. Whether the occurrence of DAI can indicate the type of traumatic event that has caused the head trauma, 2. Whether the presence of axonal damage in cases of hypoxia, ischaemia and other pathological conditions casts a shadow on the post-mortem pathological diagnosis of DAI and totally negates it, or there are certain clues in the findings that can point to the aetiology of the axonal damage. This paper discusses our findings based on neuropathological examination of 60 forensic cases of closed head injury. The neuropathological examination included: a macroscopic examination of the coronal sections and a microscopic examination involving an immunohistochemical method with antibody against β-amyloid precursor protein. Our findings indicate that DAI, as a clinicopathological entity, is undoubtedly an acceleration–deceleration injury, predominant in road traffic accidents as it is classically outlined, and cases of falling from a considerable height. Our findings point to a certain difference between the features of traumatic and ischaemic axonal damage. In this paper we also investigate the correlation between pathological grades of DAI and the impairment of the brain function before death.