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Author: search.filters.author.Zlatkova, MilicaHas files: Yes

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    ANESTHETIC MANAGEMENT FOR PATIENT WITH TRACHER COLLINS SYNDROME SCHEDULED FOR ELECTIVE CESAREAN DELIVERY
    (Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2018-12)
    Zlatkova, Milica
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    Ivanov, Emilija
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    Popovska, Rusanka
    Tracher Collins Syndrome is an autosomal dominant genetic disorder, as a result from mutation in TCOF1 gene. Other names for Treacher Collins Syndrome include Franceschetti- Zwalen-Klein syndrome, mandibulofacial dysostosis (MFD), zygo-auro-mandibular dysplasia and Treacher Collins Franceschetti syndrome. These changes cause deformities of the facial bones and occurrence at antimongoloid slant of the eyes, micrognathia and deformity of the ears. Complications may include breathing problems, seeing problems, cleft palate and hearing lost. Diagnosis of TCS is made through clinical evaluation, radiographic examination and molecular genetic analysis. Treatment is tailored to the specific needs of each individual by a multidisci- plinary craniofacial management team. We report a case of TCS with second twin pregnancy achieved with IVF. The first pregnancy ended with c-section (and death of the newborn after 23 days of delivery due to dysmorphia – TCS on the fetus). The patient was hospitalized at our clinic for evaluation and ending of pregnancy with elective section cesarean. The patient was managed successfully under regional anesthesia which is generally preferred technique to general anesthesia, in order to avoid potential complications associated to difficult airway management. The patient was left home on the fifth postoperative day with her two healthy children.
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    Intravenous Remifentanil for Labor Analgesia - A Review
    (Medical Faculty Ss. Cyril and Methodius University in Skopje, 2016)
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    Ivanov, Emilija
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    In modern obstetrics there has been a need for safe, efficient, and easy-to-use systemic analgesia with a rapid and short onset, and without an effect on either mother or fetus. Although epidural analgesia remains the gold standard for labor analgesia, opioids applied intravenously can be very useful in cases when epidural analgesia is contraindicated, refused by the patient, or in the absence of skilled anesthesiologist. Closest to the ideal for systemic analgesia is remifentanil, a potent, ultra short-acting μ-1 agonist, which is rapidly metabolized in both mother and fetus. This article, through a literature review, will present the efficacy of remifentanil, its pharmacokinetics, the most effective dose, the safety for both mother and fetus and satisfaction for the mother. The results available show that remifentanil can be quite a satisfactory alternative to neuroaxial analgesia, hence taking its deserved place in modern obstetrics. A low number of reported side effects from mother and child are enough to open a field for future research.