Faculty of Medicine
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Item type:Publication, THERAPEUTIC APPROACH IN RISPERIDONE INDUCED HYPERPOLACTINEMIA(2022); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Temporary use of glucose sensors in type 1 diabetes patients on continuous subcutaneous insulin infusion(2020); ; Background and Aims: The aimof this study was to evaluate the impact of temporary use of real-time continuous glucose monitoring (RT-CGM) on glycemic ontrol in patients with type 1 diabetes (T1D) on continuous subcutaneous insulin infusion (CSII). Methods: The retrospective analysis was performed in patients with T1D on CSII, Minimed 754 (Medtronic, Northridge, CA) with HbA1c>7.5%. Minilink transmitter with Enlite Sensors (Medtronic, Northridge, CA) was used as RT-CGM, which was connected to the CSII for seven days at the beginning, 3 months and 6 months. One-hour training session on how to use the sensor was obtained in all patients prior CGM start. Data was downloaded using CareLink Therapy Management. Software (Medtronic, Northridge, CA) and specific changes in basal and bolus insulin, re-education on carb-counting, physical activity and hypoglycemia/ hyperglycemia were given to the patients. HbA1c was obtained before, 3 months and six months after the study. Results: 76 patients (age 18.4±4.9 years) with diabetes duration of 7.8±2.3 years ans CSII use of 2.7±0.9 years were enrolled in the study. The mean HbA1c decreased from 7.9±0.7% at baseline to 7.1±0.5% at the end of the study (p=0.03). Re-education was performed on the following topics: carb counting 43%, hypoglycemia/hyperglycemia treatment 29% and physical exercise 21% of the patients. Conclusions: Temporary use of CGM can improve glycemic control in T1D patients on CSII. Further investigation on larger groups should be performed to confirm our finding. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LONGTERM DEFICIENT CALCIUM INTAKE ASSOCIATION WITH BONE TURNOVER MARKERS, HIP AND SPINE BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN(2019); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTHROPOMETRIC INDEXES OF VISCERAL OBESITY RELATIONS TO DYSLIPIDEMIC PROFILE IN METABOLIC SYNDROME(2019); ; Zivkovic, MarijaIntroduction: Visceral obesity and dyslipidemia are the main characteristics of the metabolic syndrome. Objective: The relationship of abdominal sagittal diameter to thigh circumference ratio (SD/T) with anthropometric indexes of visceral obesity waist circumference (WC) and waist hip ratio (WHR) was determined as well as their association with lipid levels. Material and methods: Triglyceride (TG), cholesterol (C), HDL and LDL levels, LDL/HDL, C/HDL as well as WC, WHR and SD/T were determined in 250 healthy women divided into 3 groups according to body fat distribution by their WHR values: 1stgr WHR<0.85; 2ndgr WHR (0.85-1.0) and 3rdgr WHR>1.0. Results: SD/T correlated significantly positively with TG and C (p<0.0001), LDL (p<0.006), LDL/HDL and C/HDL (p<0.0001), also with WC and WHR (p<0.0001), and negatively with HDL (p<0.001). WC and SD/T levels were significantly higher in the 3rd gr (125.16±15.26cm; 0.49±0.38) compared to the 2nd gr (109±14cm; 0.39±0.43) and the 1stgr (88±17cm; 0.32±0.37)(p<0.0001). TG levels in the 3rd gr (1.87±0.69ng/ml) were significantly higher compared to the 1st gr (1.03±0.42ng/ml) and the 2ndgr (1.69±0.92ng/ml) (p<0.0001). HDL in the 3 rd gr was (0.95±0.23ng/ml), significantly lower compared to the 1stgr. (1.24±0.27ng/ml) (p<0.001) and 2n dgr (1.07±0.39ng/ml) (p<0.028). LDL, C/HDL, LDL/HDL and C levels were also significantly higher in the 3rdgr. Conclusion: Visceral obesity was characterized with increased values of WHR, WC and SD/T, which were positively related to dyslipidemic profile. Positive relation of SD/T with atherogenic lipids, atherogenic indexes, WHR and WC, and negative relation with HDL, confirmed it as an important anthropometric diagnostic parameter of visceral obesity in metabolic syndrome. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY FAT DISTRIBUTION CHANGES DURING WEIGHT LOSS DETERMINED BY DUAL-ENERGY X-RAY ABSORPTIOMETRIC INDEXES OF ABDOMINAL OBESITY(2019); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Trunk/total index determined with dual-energy x-ray absorptiometry in obese women with and without Cushing syndrome(2018); ; - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Body weight reduction relationship to insulin resistance(2018); ; Introduction: Obesity is characterized with insulin resistance and positive influence of the body weight reduction on the insulin sensitivity. The aim of this study was to discover the influence of not significant body weight reduction on insulin sensitivity. Materials and methods: The sample comprised 28 women with mean age 26.14±7.29yr. The mean values of the following parameters were determined: body weight (BW), BMI, waist circumference (W), blood glucose (G), insulin levels (I) and HOMA index=G*I/22.5 (H), before and 1 year after the continuous diet regimen. Results: Mean BW values were 103.29±18.64kg, and reduced to 93.07±18.33kg. The difference of 10.21±6.24kg showed mean 9.91±6.07% reduction of the BW. Mean BMI values were 38.57±6.9kg/m2 and reduced to 35.09±6.8 kg/m2. The difference was 3.47±2.17 kg/m2 and indicated 9.05±5.74% BMI reduction. W reduced from 112.86±14.23cm to 104.21±14.13cm. The difference was 8.64±4.4cm and indicated 7.66±4% W reduction. BW, BMI and W changes were not significant (p>0.05). G levels reduced from 5.96±1.05mmol/l to 5.06±0.7mmol/l, with mean reduction of 1.01±0.09mmol/l (13.79±15.1%) of the start value (p<0.013). I values 31.44±12.18μU/ml were reduced to 16.68±6.5μU/ml, with difference of 14.76±16.32μU/ml (44.03±20.85%) of the start value and H value 8.34±3.33 reduced to 3.77±1.55, for the difference of 4.57±3.08, 51.84±20.32% of the pretreatment value (p<0.0001). Conclusion: This study concluded that insignificant body weight reduction improved glucose metabolism, reduced insulin levels and especially increased significantly insulin sensitivity. It is very important that insignificant body weight reduction reduced insulin resistance and consecutive risk of diabetes and cardiovascular complications. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Type 1 diabetes and long-term continuous subcunatenous insulin infusion therapy: a 10-year experience from(Mary Ann Liebert, 2017-12); ; Todorovska Jovanovska, BiljanaBackground: Subcutaneous insulin infusion (CSII) therapy is a challenge for both patients and healthcare providers. The long-term CSII use is scarce. The aim of this study is to describe the impact of CSII therapy for 10 years of use at our center. Methods: This single-center retrospective study includes 162 type 1 diabetes patients using CSII for >3 years during October 2004 until October 2014. Data were collected through the electronic medical record system, cross-sectional analysis (telephone, e-mail, or social media), and CSII reports generated by Carelink Therapy Management Software (Medtronic, Northridge, CA). Results: Patients were analyzed in three age groups: 12–18, 19–24, and >25 years. All patients were treated with CSII for >3 years. Total daily dose of insulin was >0.9 U/(kg·day) in age group 12–18 years old, which was significantly higher than other two age groups (P < 0.05). Basal ratio was lower in younger age (<40%) and showed trend of increasing with age and longer diabetes duration (up to 44%). Younger patients used bolus wizard on regular basis (>75%), which was significantly higher than other age groups (P < 0.05). More than 50% of patients achieved glycated hemoglobin (HbA1c) <7.0% and >70% of patients achieved HbA1c <7.5%. HbA1c level significantly changed from baseline in all groups (P < 0.05). Conclusion: Our study shows improved glucose control in long-term CSII users. A reduction of HbA1c levels by −1.1% was maintained during the study period. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Diabetes in pregnancy and risk for mother and newborn(2018); ; ; Introduction: DM in pregnancy carries a risk for the course of pregnancy, mother and fetus. It may be progestational (DM1 and DM2) and gestational DM (GDM). Aim: Bad glycemic control before and after conception increases risk for neonatal mortality and congenital malformations. Material and methods: At the clinic for endocrinology for a period of one year were analyzed the risk factors for GDM, glycemic control, maternal and fetal risks in 43 DM pregnant patients. Results: The patients were aged 25-47 years, one of them (2.4%) with DM1, 5 (11.6%) with DM 2 and 37 (86%) with GDM. Of the risk factors for GDM: 31 (72%) had> 30 years, 2 (4.6%) had GDM in the previous pregnancy (PP), 6 (13.9%) had a dead fetus in PP, 26 (60%) have DM in a family. Average HbA1C was 6,4 %, from which 55,6% had HbA1C>6% and 44,4% had HbA1C<6 %. Hypertension had 10 (23.3%) patients, of whom 7 (16.3%) had hypertension in PP and 3 (7%) in this pregnancy. Pregnancy complications: 3(6.9%) had pre-eclampsia, 12 (27.9%) gave birth before 37 weeks of gestation, of which 4 (9.3%) were over 30 years old and 1 (2.3%) became pregnant with invitro fertilization. From obstetric complications: 11 (25.6%) had polyhydramnios, 4(9.3%) macrosomia. The average body weight of a newborn was 3160 grams. A newborn born with a ventricular septal defect and one with a multiorgan disease. Average APGAR score 7/8. Conclusion: Optimal pre-conception glycemic control with HbA1C<6.5% and in pregnancy HbA1C<6% is required to reduce the risk of spontaneous abortions and congenital anomalies.