Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Spectrum of Kidney Diseases in Children Associated with Low Molecular Weight Proteinuria(ID Design 2012/Scientific Foundation SPIROSKI, 2018-05-20); ; Proteinuria, in addition to haematuria, is the most important laboratory parameter in patients with nephro-urological diseases. Low molecular weight proteinuria (LMWP) is of particular importance because some diseases genetic and tubulointerstitial are diagnosed based on its presence. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria(S. Karger AG, 2018); ; Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Low Molecular Weight Proteinuria in Children with Distal Renal Tubular Acidosis(Walter de Gruyter GmbH/Macedonian Academy of Sciences and Arts, 2018-07-01); ; ; Momir PolenakovicDistal renal tubular acidosis (dRTA) (MIM #267300, #602722 and #179800) is a rare inherited tubulopathy characterized by the inability of the distal tubule to acidify the urine with consecutive systemic acidosis. The clinical features include polyuria, polydipsia, poor appetite, failure to thrive, short stature and rickets. Prominent biochemical features are hypokalemia, hypercalciuria and hypocitraturia. There are reports on patients who presented with unusual biochemical features such as low molecular proteinuria, hypophosphatemia, hypouricemia, generalized hyperaminioaciduria, hyperoxaluria and other making diagnostic confusion to the clinicians. In this work, we report on a series of 8 children with clinically, biochemically and genetically proven dRTA who present with low molecular proteinuria at the disease onset. With metabolic compensation of the disease, there was complete resolution of the low molecular weight protenuria and other proximal tubular abnormalities in all children. Late recognition of the disease with long standing hypokalemia and acidosis may result in abnormal expression and function of the transporters in the proximal tubules. Sodium dodecyl sulphate polyacrylamide gel electrophoeresis is an accurate method for detection and follow up of patients with low molecular weight proteinuria.</jats:p>