Faculty of Medicine

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Author: search.filters.author.Ohyashiki, KEnd date: 1989

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    Translocation between chromosomes 1 and 9 in childhood acute lymphoblastic leukemia
    (ELSEVIER SCIENCE INC, 1986-03-01)
    Ohyashiki, K
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    Ohyashiki, J H
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    Ryan, D H
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    Rowe, J M
    A case of a non-T, non-B acute lymphoblastic leukemia with a translocation between chromosomes #1 and #9 is described. The breakpoints in these chromosomes were determined to be at bands 1q23 and 9p22, respectively. The breakpoint in chromosome #1 was at the same site as that in a subgroup of acute lymphoblastic leukemia with t(1;19), and the breakpoint in #9 was the same as that in t(9;11)(p22;q23) in acute monoblastic leukemia. We discuss the possible association between these chromosome bands (1q23, 9p22, 11q23, and 19p13) and the morphologic features of the leukemic cells. The breakpoint in chromosome band 1q23 may be specifically associated with acute lymphoblastic leukemia.
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    Secondary acute myeloblastic leukemia with a Ph translocation in a treated Wegener's granulomatosis
    (ELSEVIER SCIENCE INC, 1986-01-15)
    Ohyashiki, K
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    Ryan, D H
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    Rowe, J M
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    Sandberg, A A
    Ph-positive acute myeloblastic leukemia (AML) developing in a treated case of Wegener's granulomatosis is reported. The patient was a 70-year-old white male who received cyclophosphamide (150 mg/day) starting in July 1978; in May 1984 the patient was diagnosed as having AML, following a diagnosis of myelodysplastic syndrome lasting 3 months. Cytogenetic study of bone marrow cells at the diagnosis of the myelodysplastic syndrome revealed a standard Ph translocation in addition to numerical chromosome changes [i.e., 45,XY, -5, -7, -8, +19, +mar/45,XY, -5, -7, -8, +19, +mar,t(9;22)(q34;q11]). The events in this case suggest a strong possibility of the Ph-positive AML being a secondary disease related to prior cyclophosphamide therapy.