Faculty of Medicine
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Item type:Publication, Visceral Leishmaniasis in the Republic of North Macedonia: A Retrospective Cohort Study(Galenos Yayinevi, 2025-11-11); ; Visceral leishmaniasis (VL) is a systemic protozoan vector-borne disease and represents the most severe clinical form of leishmaniasis, with fatal outcomes if left untreated. This study aimed to evaluate the key epidemiological, clinical, and laboratory findings, treatment options, and outcomes in patients with VL. Materials and Methods A retrospective analysis was conducted on the epidemiological and clinical characteristics of 84 patients diagnosed and treated for VL at the University Hospital for Infectious Diseases in Skopje, Republic of North Macedonia (RNM), between 2001 and 2023. Results The median age of patients was 47 years (range 1-74), with 77.4% being male. Contact with dogs was reported in 41.7% of cases. Seven percent of patients were immunosuppressed, and all were Human Immunodeficiency Virus-negative. The median time from symptom onset to diagnosis was 30 days (range 4-330 days). The predominant clinical manifestations were splenomegaly (97.6%), fever (96.4%), hepatomegaly (90.5%), and weight loss (54.8%). On admission, anemia, leukopenia, thrombocytopenia, and hypergammaglobulinemia were detected in 75%, 73.8%, 70.2%, and 63.1% of patients, respectively. A favorable outcome was achieved in 91.7% of cases; therapeutic failure occurred in 1.2%, and 7.1% of patients died. Conclusion VL should be considered a crucial differential diagnosis in patients from the RNM presenting with prolonged unexplained fever, splenomegaly, cytopenia, and hypergammaglobulinemia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hybrid peer-reviewed journals and publishing model: Bias or impartiality in editorial policy(Pensoft Publishers, 2025-03-24); ; Tsachev, IliaIn recent years, there has been a significant increase in scientific productivity—an increased number of published original articles, reviews, short communications, case reports, and letters to the editor. In this regard, there is a large number of peer-reviewed journals in all fields of scientific knowledge, including in the field of biomedical sciences. Many studies indicate the existence of so-called journal editorial board bias and acknowledge the difficulty of eliminating it. We present our brief opinion on an important topic such as how publishing policy in some peer-reviewed journals leads to feelings of bias and inequality among authors and how to address this. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPORTED FURUNCULAR MYIASIS IN THE REPUBLIC OF NORTH MACEDONIA - A THREE CASE STUDY(Peytchinski Publishing Ltd., 2024-10-06); ; ; Nikolic, JadrankaFuruncular myiasis is a parasite disease most commonly found in tropical regions. It is the most widespread clinical manifestation of myiasis that occurs when larvae of various species of flies penetrate the skin and cause cutaneous lesions. Objective: To present cases of imported furuncular myiasis acquired during a stay in Africa. As far as we know, these are the first cases reported in the Republic of North Macedonia. Case report: We present a group of three patients with myiasis acquired during a journey to Tanzania. The symptoms occurred three days after being bitten by hairy flies, and manifested with sporadic papular lesions accompanied by pain and itching. They contacted our hospital 6 days after being bitten. During examination of all three patients, on the bitten spot, several papulonodular, indurated, separated lesions, with centrally positioned eschar, localized on the upper, lower extremities and glutes were noted. On the sixth day of symptom appearance, the patients had sensations of subcutaneous movements in skin lesions, dropping out of the eschar and a beginning of larvae coming out from the nodular changes. All cutaneous changes were treated by a plastic surgeon by extirpation of larvae from them. Favorable clinical course followed, with a complete regression of the local findings. Larvae have been forwarded to the Microbiology and Parasitology Institute with myiasis confirmation. Conclusion: In patients with cutaneous papulonodular changes returning from tropical regions it is necessary to include myiasis in differential diagnostic consideration.