Faculty of Medicine
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Item type:Publication, Cysteinyl leukotrienes and hematoma-correlation study(League against Epilepsy of Macedonia, 2016); ; ; Baneva, Emilija - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Spectrum of functional neurological disorders(2018); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Intracerebral Hematoma, Perihemorrhagic Edema and Urinary Excreted Cysteinyl Leukotrienes Correlation Study(Walter de Gruyter GmbH, 2014-08-01); ; ; <jats:title>Abstract</jats:title><jats:p><jats:bold>Introduction.</jats:bold>Several mechanisms in formation of perihemorrhagic edema are activated after contact of brain tissue-extravasated blood in intracerebral hemorrhage. Cysteinyl leukotrienes (cysLT) (C4, D4, E4) are included in this process as significant edema factors and they determine the neurological deficit and outcome. The study aim was a 5-day follow-up (admission/3 day/5 day) of urinary cysLT, hematoma volume, edema volume values and their correlation in patients after spontaneous, primary supratentorial intracerebral hemorrhage.</jats:p><jats:p><jats:bold>Methods.</jats:bold>An enzyme immunoassay was used for urinary cysLT measured in 62 patients and 80 healthy controls. Hematoma and edema volumes were visualized and measured by computed tomography and mathematically calculated with a special spheroid shape formula (V=AxBxC/2).</jats:p><jats:p><jats:bold>Results.</jats:bold>CysLT of hemorrhagic patients (1842.20±1413.2, 1181.54±906.2, 982.30±774.2pg/ml/mg creatinine) were significantly excreted (p<0.01). Brain edema (12.86±13.5, 22.38±21.1, 28.45±29.4cm<jats:sup>3</jats:sup>) was significantly increased (p<0.01). Hematoma volume values (13.05±14.5, 13.13±14.7, 12.99±14.7cm<jats:sup>3</jats:sup>) were not significant (p>0.05). A high correlation (multiple regression) between cysLT, hematoma and edema was found on the 3<jats:sup>rd</jats:sup>day (R=0.6) and a moderate correlation at admission (R=0.3) and on the 5<jats:sup>th</jats:sup>day (R=0.3).</jats:p><jats:p><jats:bold>Conclusion.</jats:bold>In our 5-day follow-up study a significant cysLT brain synthesis and significant brain edema progression versus constant hematoma volume values in hemorrhagic patients was found. A high correlation between cysLT, hematoma and edema volume was found on the 3<jats:sup>rd</jats:sup>day, a moderate correlation on admission and on the 5<jats:sup>th</jats:sup>day, which means that high cysLT and hematoma values were associated with high/moderate edema values.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Refractory Epilepsy-MRI, EEG and CT scan, a Correlative Clinical Study(ID Design 2012/DOOEL Skopje, 2016-03-15); ; ; Refractory epilepsies (RE), as well as, the surgically correctable syndromes, are of great interest, since they affect the very young population of children and adolescents. The early diagnosis and treatment are very important in preventing the psychosocial disability. Therefore MRI and EEG are highly sensitive methods in the diagnosis and localization of epileptogenic focus, but also in pre-surgical evaluation of these patients. The aim of our study is to correlate the imaging findings of EEG, MRI and CT scan in refractory symptomatic epilepsies, and to determine their specificity in detecting the epileptogenic focus.