Faculty of Medicine
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Item type:Publication, Incidence of Cushing’s Disease in the Republic of North Macedonia for the period from 2013 to 2020, according to data derived from the national health system.(University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, University “Ss. Cyril and Methodius” - Skopje, 2022-10-13); ; ; Stevchevska, AleksandraCushing’s disease is a rare endocrine disorder characterized by increased secretion of adrenocorticotrophic hormone (ACTH) by a corticotropic pituitary adenoma. In our country there are no data on the incidence of Cushing’s disease and only sporadic case report have been published. Aim: To find the annual incidence rates of Cushing’s disease in the Republic of North Macedonia for the period from 2013 to 2020, based on data derived from the National eHealth System. Methods: The National eHealth System was searched for all patients with ICD-10 diagnosis E24.0 in their electronic healthcare records. The annual incidence rate of Cushing’s disease was estimated per 106 persons, according to the initial occurrence of the diagnosis. The National Data records from State Statistical Office (MAKSTAT) for the population per year were used. Results: The number of newly diagnosed registered cases with Cushing’s disease was 3 in year 2013, 4 in 2014, 5 in 2015, 2 in 2016, 4 in 2017, 4 in 2018 and there were no new cases diagnosed in 2019 and 2020. Compared to the registered number of citizens by years, the annual incidence rate of Cushing’s disease was 1.45 per one million for 2013; 1.93 /106 for 2014; 2.4/106 for 2015; 0.96 /106 for 2016; 1.93 /106 for 2017 and 1.92 /106 for 2018. The average annual incidence rate for Cushing’s disease was 1.77 cases per 100000 inhabitants. Conclusion: The worldwide incidence rate of Cushing’s disease is 1.2-2.4 cases in a million. The average annual incidence rate in our country corresponds to the reported global incidence. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Unilateral Graves Orbitopathy-case report(Bioscientifica, 2022-08); ; Graves’ Orbitopathy (GO) is the most common extra thyroidal feature of autoimmune thyroid disease presentation. It is characterized by development of orbital inflammation that involves both, adipose tissue and extra-ocular muscles. The condition is associated with increased psychological burden and in severe cases may lead to optic nerve damage, causing blindness. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with the condition. It has been shown that older age, male sex, active and severe disease are the most significant factors for development of unilateral form of the disease. The pathophysiological mechanisms of unilateral presentation of GO still remains uncertain. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessment of Prevalence and Risk Factors for Diabetic Retinopathy in Patients with Type 1 and Type 2 Diabetes Examined at a Tertiary Care(Walter de Gruyter GmbH, 2023-07-01); ; ; Guceva Laban, Nevenka<jats:title>Abstract</jats:title> <jats:p> <jats:bold>Introduction</jats:bold>: Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus and the leading cause of visual impairment and blindness. The aim of the study was to estimate and compare the prevalence of DR and to determine an association between DR and systemic risk factors in hospitalized type 1 (DMT1) and type 2 (DMT2) diabetic patients.</jats:p> <jats:p> <jats:bold>Material and methods</jats:bold>: We analyzed 260 patients with diabetes, 43 with DMT1 and 217 with DMT2. The following data were collected: age, gender, type and duration of diabetes, glycemic control, blood pressure, estimated glomerular filtration rate, ophthalmologic examinations and routine biochemical parameters.</jats:p> <jats:p> <jats:bold>Results</jats:bold>: Out of the total number of 260 patients, 77 (29.6%) had non-proliferative DR (NPDR), 21 (8.1%) had proliferative DR (PDR), 29 (11.1%) had diabetic macular edema (DME), and 69 (23.5%) had diabetic cataracts. Forty-three (16.5%) patients were previously diagnosed with DMT1 and 217 (83.5%) with DMT2. The duration of diabetes was not significantly longer in DMT1 (12.8±11.2 years) in comparison to DMT2 (11.07±8.1 years). The prevalence of NPDR and PDR did not differ statistically in either groups. DME was more prevalent in DMT2 than in DMT1 (P<0.05). Diabetic cataract was found in 26.7% vs. 6.7% of patients with DMT2 and DMT1, respectively (p<0.01). The duration of diabetes significantly correlated with NPDR and PDR in DMT1 (r=o.31, p<0.05; r=0.55, p<0.001, respectively). In DMT2, significant correlations were found between the duration of diabetes and cataract, NPDR, PDR and DME (r=0.31, p<0.001; r=0.43 p<0.01, r=0.16 p<0.05 and r=0.20 p<0.01, respectively). Fasting plasma glucose (FPG) significantly correlated with PDR (r=0.258, p<0.05), while HbA1c with DME (r= 0.15 p<0.05).</jats:p> <jats:p> <jats:bold>Conclusion</jats:bold>: The duration of diabetes and hyperglycemia were associated with DR in both types of diabetes.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SP136DEGREE OF CHRONIC KIDNEY DISEASE (CKD) IN TYPE 2 DIABETIC PATIENTS INCREASE THE PREVALENCE OF FOOT ULCERATION(Oxford University Press (OUP), 2018-05-01); ; - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, A CASE OF IDIOPATHIC OSTEOPOROSIS IN 43 YEARS OLD MALE PATIENT(Scientific association of endocrinologists and diabetologists of Macedonia, 2022-10);