Faculty of Medicine
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Item type:Publication, DUAL STAINING CYTOLOGY WITH P16/KI67 FOR CERVICAL CANCER SCREENING(University Ss. Cyril and Methodius in Skopje, 2024); ;Kijajova, Ivana; ; Gjirevski, Vlatko - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPLEMENTATION OF P16/KI67 DUAL STAINING CYTOLOGY FOR DETECTING CERVICAL DYSPLASIA(University Ss. Cyril and Methodius in Skopje, 2025-09-18); ; ; ; Stanojevik, Verdi - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Heart tuberous sclerosis in pregnancy: a case report(Македонско лекарско друштво = Macedonian medical association, 2023); ;Jashari, Emine; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Echocardiographic Heart Changes in Pregnancies Complicated with Gestation Hypertension and Preeclampsia(International Scientific Invention Journals, 2019-02-13); ;Milkovski, Daniel; ; Introduction: Echocardiography as an imaging method is increasingly being used in obstetrics in the management of hemodynamic changes which occur in normal but also in pregnancies with gestational hypertension/preeclampsia. Aim: The aim of the study is to show that some of the heart changes in pregnancies complicated with gestational hypertension and preeclampsia are abnormal and further follow up of these patients is needed. Methods: A total of 81 patients were enrolled in the study. The patients were further divided in two groups. Pregnant women with gestational hypertension or preeclampsia (51) and a control group of normotensive pregnancies (30). A total of 3 echocardiograph exam were made, the first upon entry in the study (28 -34 g.w), the second 2 weeks after delivery and the last 6 months after delivery. Results and discussion: We found several statistically significant results that involve the IVS, PWLV, LKM, left chamber hypertrophy and diastolic function. Diastolic dysfunction usually shows up before systolic dysfunction in the evolution of ischemic/hypertensive cardiovascular disease and is of prognostic value in predicting long term cardiovascular morbidity. The changes seen 6 months after delivery on our last control mean that those changes are permanent and need further prevention strategies. Conclusion: From the noninvasive methods echocardiography is the most favorable method in identifying structural changes and functional changes in pregnancies with hypertension. Echocardiography allows fast, reproducible information and is both safe for mother and fetus. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chorangioma of placenta: single center analysis(Wiley, 2022-10) ;Kochoska, Milka; ; ;Kochmanovska Petreska, SvetlanaRistovski, GrigorBackground: The most common benign neoplasms of the placenta are non-trophoblastic tumours. They include chorioangioma, teratoma, leiomyoma and hepatocellular adenoma. Chorioangioma is the most common subtype. The incidence of chorangioma is 0.5–1.0%. Small chorangiomas are clinically insignificant. Giant chorioangioma is rare tumours, measuring more than 4 cm in diameter and seen in association with elderly primi, twin pregnancy, hypertension, diabetics, and female fetus. Giant chorioangioma is associated with complications that can affect the mother, fetus, or neonate. Aims: This is a retrospective study of chorangioma cases seen at Institute of Pathology, Medical faculty, Skopje during a 10-year period from 2012 to 2021. Methods: Macroscopic findings, gestational weeks at delivery, maternal age and outcome of pregnancy were evaluated. Histological and immunochistochemical analyses of the placental chorangiomas were preformed. Results & Conclusions: In period of 10 years 6 causes of placental chorangioma were clinically identified and histopathologically confirmed. Four cases were giant chorangiomas measuring from 8 to 13 cm. One of the cases was identified as chorangioma of the umbilical cord. Three of the cases shows potential maternal risk factors like primary infertility, extreme obesity and post COVID status. The median gestational age of delivery was 33 + 6 weeks and 39.6 weeks, respectively. The maternal age range was between 25 to 34 years. Four of the pregnancies had favourable outcome with no complications during and after birth. One was with foetal distress and one with premature delivery. Microscopic examination of the mass showed numerous proliferative thin walled capillaries lined by f lattened endothelium and separated by fibrous stroma. This was further confirmed by IHC for CD34, which showed strong reactivity of endothelial cells. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A rare case of pleomorphic dermal sarcoma presented during pregnancy, a case report(John Wiley & Sons, Inc., 2024) ;Milkovski, Daniel; ; ;Gjirevski, VlatkoKijajova, IvanaSoft tissue sarcomas are rare tumors arising in mesenchymal tissues and can occur almost anywhere in the body. They are rarely diagnosed during pregnancy. Pleomorphic dermal sarcoma (PDS) are dermal-based malignant tumors that usually present on sun-exposed sites of elderly patients and are morphologically similar to atypical fibroxanthoma (AFX). PDS is considered an aggressive cancer and likely to metastasize and reappear. Early detection and aggressive treatment improve outcomes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antiphospholipid syndrome and pregnancy(MedCrave Group, LLC, 2021-10-15) ;Jasovic-Siveska, Emilija; Milkovski, Daniel - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DIASTOLIC DYSFUNCTION IN GESTATIONAL HYPERTENSION/ PREECLAMPSIA(DEPARTMENT OF ANAESTHESIA AND REANIMATION, FACULTY OF MEDICINE, “SS. CYRIL AND METHODIUS” UNIVERSITY, SKOPJE, MACEDONIA, 2024-03); ; ;Milkovski, Daniel; Introduction: Hypertensive disorders in pregnancy including preeclampsia are present in 10% of pregnancies and are one of the biggest reasons for both maternal and fetal morbidity and mortality. Materials and Methods: The study was undertaken at the University Clinic for Gynecology and Obstetrics in Skopje, North Macedonia. After initial assessment, 81 patients were enrolled in the study after signing a written consent. Patients were divided into two groups depending on whether they had hypertension or not. In the hypertensive group 51 patients were enrolled and 30 normotensive pregnancies were used as controls. Results: Based on the values of the parameters of diastolic function obtained with PDA of the transmittance flow and the values of the parameters obtained with TDI of the longitudinal movement of the mitral ring, diastolic dysfunction was found in 17 (33.2%) pregnant women of the studied population, LV function (p <0.001). In the pregnant women from the examined group in whom the presence of LV diastolic dysfunction was identified, the disorders were of mild degree, that is type of delayed relaxation of LV in all 17 pregnant women. Conclusion: Early recognition and management of symptoms are essential. Women who suffer from hypertensive disorders in pregnancy require close monitoring after delivery. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CORRELATION BETWEEN SFLT/PLGF RATIO HIGHER THAN 200 AND ALTERED LABORATORY PARAMETARS OF PREECLAMPSIA IN HOSPITAL SETTINGS PATIENTS(SHMSHM - AAMD, 2024); ; ; ; Milkovski, DanielPreeclampsia affects 2–7% of all pregnancies. Worldwide it is responsible for 500,000 fetal/neonatal deaths and 70,000 maternal deaths every year. Anti-angiogenic factor, soluble fms-like tyrosine kinase 1 (sFlt-1) and the pro-angiogenic factor, placental growth factor (PlGF) are usefull markers for screening, diagnosis and prognosis of preeclampsia. Aim: To show our experience about the correlation between angiogenic levels and laboratory blood and urine parametars in hospital settings patients with preeclampsia. Material and methods : Retrospective clinical study was performed in 2 years period. One hundred pregnant women with preeclampsia hospitalized in University clinic for obstetrics and gynecology in peripartal intensive care unite were evaluated .SFLT/PLGF ratio (Elecsys sFlt-1 and PlGF immunoassays), differential blood count, AST, ALT, LDH, uric acid, urine analysis (qualitative, quantitative proteinuria) were evaluated in all patients. Questionaire about sociodemographic data, age, parity, BMI, poor obstetric history, cigarette smoking, use of Aspirin or Clexane during actual pregnancy was taken during admission. Related to the sFlt-1/PIGF ratio (< 200 or ≥ 200) women were divided into two groups with 50% participants each. Results: Our patients with SFLT/PLGF ratio >200 were significantly younger, had significantly higher proteinuria (++,+++ and quantitative), had significantly higher levels of LDH and AST and were admitted at hospital treatment at significantly lower gestational week compared to ratio < 200. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SMALL INTESTINE INTUSSUSCEPTION DUE TO GASTROINTESTINAL STROMAL TUMOUR IN PREGNANCY: A CASE REPORT(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2022); ; ; ;Simonovska Paneva, IvaGastrointestinal stromal tumour (GIST) is very rare in pregnancy and only a few cases have been described in the literature. We present a case of a 38-year-old primigravida, presented with non-specific symptoms for the first time in the second trimester. Due to the non-specificity of the symptoms on one hand and the rarity of the tumour on the other, it took a long time for the final diagnosis to be made. Accidentally, on a routine obstetric ultrasound examination, a solid tumour formation was observed, localized under the lower pole of the left kidney. On MRI of the abdomen, in front of the left kidney there was a tubular structure, in close relation with small intestine, suspected for intussusception. At 28 weeks of gestation, an exploratory laparotomy was performed with resection of the involved part of the jejunum and TT anastomosis. Pregnancy was terminated electively, by caesarean section, in 38+6 gestational weeks. The clinical presentation of the GIST depends on the primary location of the tumour. Due to the extremely rare occurrence of these tumours in pregnancy, there is no solid scientific evidence for the most appropriate time of their treatment and the time of termination of pregnancy. The biggest challenge in pregnancy is timely diagnosis and treatment, without impact on the foetus. A multidisciplinary approach is needed. In our case, the severity of the mother’s symptoms outweighed the danger to the foetus from general anaesthesia and surgery itself.
