Faculty of Medicine
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Item type:Publication, DIASTOLIC DYSFUNCTION IN GESTATIONAL HYPERTENSION/ PREECLAMPSIA(DEPARTMENT OF ANAESTHESIA AND REANIMATION, FACULTY OF MEDICINE, “SS. CYRIL AND METHODIUS” UNIVERSITY, SKOPJE, MACEDONIA, 2024-03); ; ; Introduction: Hypertensive disorders in pregnancy including preeclampsia are present in 10% of pregnancies and are one of the biggest reasons for both maternal and fetal morbidity and mortality. Materials and Methods: The study was undertaken at the University Clinic for Gynecology and Obstetrics in Skopje, North Macedonia. After initial assessment, 81 patients were enrolled in the study after signing a written consent. Patients were divided into two groups depending on whether they had hypertension or not. In the hypertensive group 51 patients were enrolled and 30 normotensive pregnancies were used as controls. Results: Based on the values of the parameters of diastolic function obtained with PDA of the transmittance flow and the values of the parameters obtained with TDI of the longitudinal movement of the mitral ring, diastolic dysfunction was found in 17 (33.2%) pregnant women of the studied population, LV function (p <0.001). In the pregnant women from the examined group in whom the presence of LV diastolic dysfunction was identified, the disorders were of mild degree, that is type of delayed relaxation of LV in all 17 pregnant women. Conclusion: Early recognition and management of symptoms are essential. Women who suffer from hypertensive disorders in pregnancy require close monitoring after delivery. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CORRELATION BETWEEN SFLT/PLGF RATIO HIGHER THAN 200 AND ALTERED LABORATORY PARAMETARS OF PREECLAMPSIA IN HOSPITAL SETTINGS PATIENTS(SHMSHM - AAMD, 2024); ; ; ; Milkovski, DanielPreeclampsia affects 2–7% of all pregnancies. Worldwide it is responsible for 500,000 fetal/neonatal deaths and 70,000 maternal deaths every year. Anti-angiogenic factor, soluble fms-like tyrosine kinase 1 (sFlt-1) and the pro-angiogenic factor, placental growth factor (PlGF) are usefull markers for screening, diagnosis and prognosis of preeclampsia. Aim: To show our experience about the correlation between angiogenic levels and laboratory blood and urine parametars in hospital settings patients with preeclampsia. Material and methods : Retrospective clinical study was performed in 2 years period. One hundred pregnant women with preeclampsia hospitalized in University clinic for obstetrics and gynecology in peripartal intensive care unite were evaluated .SFLT/PLGF ratio (Elecsys sFlt-1 and PlGF immunoassays), differential blood count, AST, ALT, LDH, uric acid, urine analysis (qualitative, quantitative proteinuria) were evaluated in all patients. Questionaire about sociodemographic data, age, parity, BMI, poor obstetric history, cigarette smoking, use of Aspirin or Clexane during actual pregnancy was taken during admission. Related to the sFlt-1/PIGF ratio (< 200 or ≥ 200) women were divided into two groups with 50% participants each. Results: Our patients with SFLT/PLGF ratio >200 were significantly younger, had significantly higher proteinuria (++,+++ and quantitative), had significantly higher levels of LDH and AST and were admitted at hospital treatment at significantly lower gestational week compared to ratio < 200.