Faculty of Medicine
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Item type:Publication, LIPOLEIOMYOMA UTERI IN POSTMENOPAUSAL WOMAN(SHMSHM - AAMD, 2025-09-09); ; ; ; Micevska, MegiLipoleiomyomas are uncommon benign neoplasms of uterus and are considered to be a variant of uterine myomas. Their reported incidence varies from 0.03 to 0.2%. Lipoleiomyoma consists of variable proportion of mature lipocytes and smooth muscle cells. These tumors generally occur in asymptomatic obese perimenopausal or menopausal women. We report this case of uterine lipoleiomyoma because of its rarity. USMT (uterine smooth muscle tumors) are divided into 5 groups according to WHO tumor classification system 2020.The most commonly used detection methods is ultrasound examination. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidence and Prevalence of Vaginal Infections in Women of Reproductive Age in North Macedonia(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-07-01); In the available literature on this subject there are many studies which describe the effects of sexually transmitted infections on pregnancy and fertility of women. Because of the frequency of the infections with the atypical bacteria of the Ureaplasma Spp., Mycoplasma Spp., Chlamydia Trachomatis, as well as HPV infections in women of reproductive age, it is easy to underestimate their importance when establishing the basis of the genital health of women of reproductive age. In this prospective analysis, conducted from 2014 to 2018 in the laboratory for HPV and Molecular diagnostics at the University Clinic of Gynaecology and Obstetrics in Skopje, North Macedonia, we analysed the results of 10,387 patients of all ages, of which 973 patients were of reproductive age. A Panel analysis was also conducted (including the above-mentioned pathogens). An HPV analysis was also conducted on 643 patients in this group. Within the group of 643 patients, there was a positive result for HPV in 26.7% of them, while in 40.9% there was a positive result for one or more pathogens on the Panel analysis of bacterial pathogens. The statistical analysis of the results showed that the most frequent of all bacterial pathogens within the Macedonian population of women of reproductive age is Ureaplasma Spp, with an incidence of 33%, followed by Mycoplasma Spp., with 7.8%, while Chlamydia Trachomatis was present in 6.4% of the cases. We should highlight that a co-infection with HPV was present in 18.5% of all the patients where there was analysis of both diagnostic procedures. The analysis of the results in the patients co-infected with HPV and at least one bacterial pathogen on the Panel Analysis, showed a very high statistical correlation (p<001). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE RELATIONSHIP OF PERSISTENT HUMAN PAPILLOMAVIRUS INFECTION AND STRESS AT THE WORKPLACE(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2025-04); ; ; Introduction: Human papillomavirus (HPV) is one of the most common sexually transmitted infections. While most genital HPV infections regress spontaneously, some persist and can progress to cervical cancer. The biological susceptibility to acquire HPV and the immunological capacity to eliminate the infection are influenced by various factors, including occupational roles, work-related stress, and burnout syndrome. Materials and methods: In our study, relevant data were collected from 71 patients, 38 of whom had documented persistent HPV infections, while 33 patients were included in the study as a control group. Among those with persistent HPV infections, HPV 16 was the most common type, followed by HPV 31 and HPV 52. Results: Job demands were assessed using the Job Demands Questionnaire. The burnout syndrome was evaluated with the Maslach Burnout Inventory. Job resources were investigated using the Hospital Survey on Patient Safety Culture Questionnaire and the English version of the Questionnaire sur les Ressources et Contraintes Professionnelles. Conclusion: Preliminary data analysis revealed significantly higher levels of stress factors in the group of patients with persistent HPV infections compared to the control group. The insights gained from assessing the impact of workplace stress on HPV infection progression will help formulate recommendations to promote the health of the working population. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HETEROGENEITY OF ENDOMETRIUM – AN INCREASED RISK FACTOR FOR ENDOMETRIAL MALIGNANCY(Македонско лекарско друштво = Macedonian Medical Association, 2021-03); ; ; Introduction. The normal postmenopausal endometrium should appear thin, homogeneous and echogenic. Endometrial cancer causes the endometrium to thicken, appear heterogeneous, have irregular or poorly defined margins, and show increased color Doppler signals. Aim. To examine the correlation between endometrial echogenicity and the risk of endometrial malignancy in postmenopausal women. Methods. This was a prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics-Skopje, divided into two groups: control and examined. The coнtrol group included 40 postmenopausal patients, hospitalized and operated on due to urogenital pathology. The examined group consisted of 80 patients divided into two subgroups – a group with uterine bleeding and the other one without uterine bleeding. According to the ultrasound verified thickness of the endometrium, the two subgroups were divided according to endometrial thickness into: the first group with endometrial thick ness from 5-8 mm; the second from > 8-11mm and the third group above 11 mm. We made ultrasound examination by measuring the echogenicity of the endometrium in both groups of patients as well as in sub groups, which were also divided into other subgroups according to endometrial thickness. Results. The probability of endometrial malignancy was significantly increased by 4,938 in heterogenous endometrium. Conclusion. There are many examples of intratumor heterogeneity in endometrial malignancy, either at the morphologic or the molecular level. Attention should be paid so as not to miss minor subpopulations of tumor cells with diagnostic and prognostic relevance. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-risk HPV E6/E7 messenger RNA testing versus HPV DNA testing in women with squamous cell abnormalities of the uterine cervix(BMJ Publishing Group Ltd, International Gynecologic Cancer Society & European Society of Gynaecological Oncology, 2017-11); ; Dabeski, AnaAims The study is performed in order to compare the results of two HPV screening methods: High-risk HPV E6/E7 mRNA and HPV DNA. Method Comparative prospective study, conducted in the period for April 2016 to March 2017 at the University Clinics for Gynecology and Obstetrics and Radiotherapy and Oncology in Skopje and Institute of Public Health of Republic of Macedonia of 98 sexually active women, age groups of 20 to 60 years, with squamous cell abnormalities on the cervical cytology. In all 98 women were done: HPV DNA testing, High-risk HPV E6/E7 mRNA testing and colposcopy and directed biopsy with endocervical curettage for histopathological analysis. Results Histopathologically, there were: 36.7% non-neoplastic lesions, 20.4% LGSIL cases, 29.6% HGSIL cases and 13.3% invasive squamous cell carcinomas. HPV DNA was found 78.6% of the cases; E6 and E7 transcripts were found in 58.2%. The rates of detection of HPV DNA and E6 and E7 transcripts were 83.3% and 22.2% for cases with non-neoplastic finding; 65.0% and 45.0% for cases with LGSIL; 75.9% and 93.1% for cases with HGSIL and 92.3% and 100% for cases with invasive squamous cell carcinoma. High-risk HPV E6/E7 mRNA testing showed a higher sensitivity than the HPV DNA testing (79.0% and 75.8%), higher specificity (77.8% and 16.7%) and a higher positive predictive value for HGSIL ( 93.1% and 75.9%) and invasive squamous cell carcinoma (100% and 92.3%). Conclusion High-risk HPV E6/E7 mRNA testing could be more powerful than HPV DNA testing for screening and investigation of HGSIL and invasive squamous cell carcinoma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prevalence of Specific Types of Human Papiloma Virus in Cervical Intraepithelial Lesions and Cervical Cancer in Macedonian Women(Academy of Medical Sciences of Bosnia and Herzegovina, 2018-02);