(Macedonian Academy of Sciences and Arts /Walter de Gruyter GmbH, 2016-11-01) ;
Nojkov, Jordan
; ; ;
Spiroska, Tatjana
The minimal effective analgesic concentration of opioids required for satisfactory analgesia may differ significantly among the patients. Genetic factors may contribute to the variable response to opioids by affecting their pharmacokinetics or pharmacodynamics.