Faculty of Medicine

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Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry
(Oxford University Press (OUP), 2019)
Boriani, Giuseppe
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Proietti, Marco
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Laroche, Cécile
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Fauchier, Laurent
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Marin, Francisco
In recent years, stroke prevention in patients with atrial fibrillation (AF) has radically changed, with increasing use of non-vitamin K antagonist oral anticoagulants (NOACs). Contemporary European data on AF thromboprophylaxis are needed.
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Contemporary stroke prevention strategies in 11 096 European patients with atrial fibrillation: a report from the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) Long-Term General Registry
(Oxford University Press (OUP), 2018)
Boriani, Giuseppe
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Proietti, Marco
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Laroche, Cécile
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Fauchier, Laurent
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Marin, Francisco
Contemporary data regarding atrial fibrillation (AF) management and current use of oral anticoagulants (OACs) for stroke prevention are needed.
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Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EURObservational research programme in atrial fibrillation general long-term registry
(Wiley, 2022-07)
Malavasi, Vincenzo L
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Vitolo, Marco
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Proietti, Marco
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Diemberger, Igor
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Fauchier, Laurent
The management of patients with atrial fibrillation (AF) and malignancy is challenging given the paucity of evidence supporting their appropriate clinical management.
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Impact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry
(Wiley, 2022-06)
Ding, Wern Yew
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Potpara, Tatjana S
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Blomström-Lundqvist, Carina
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Boriani, Giuseppe
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Marin, Francisco
Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF.
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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
(Springer Science and Business Media LLC, 2020)
Zhang, Haoyu
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Ahearn, Thomas U
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Lecarpentier, Julie
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Barnes, Daniel
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Beesley, Jonathan
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P < 5.0 × 10-8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate < 0.05). Five loci showed associations (P < 0.05) in opposite directions between luminal and non-luminal subtypes. In silico analyses showed that these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease and 37.6% for triple-negative disease. The odds ratios of polygenic risk scores, which included 330 variants, for the highest 1% of quantiles compared with middle quantiles were 5.63 and 3.02 for luminal A-like and triple-negative disease, respectively. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
(Cold Spring Harbor Laboratory, 2019-09-24)
Zhang, Haoyu
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Ahearn, Thomas U.
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Lecarpentier, Julie
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Barnes, Daniel
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Beesley, Jonathan
<jats:title>Abstract</jats:title><jats:p>Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 <jats:italic>BRCA1</jats:italic> mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status and tumor grade. We identified 32 novel susceptibility loci (<jats:italic>P</jats:italic><5.0×10<jats:sup>-8</jats:sup>), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate <0.05). Five loci showed associations (<jats:italic>P</jats:italic><0.05) in opposite directions between luminal- and non-luminal subtypes. <jats:italic>In-silico</jats:italic> analyses showed these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 37.6% for triple-negative and 54.2% for luminal A-like disease. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.</jats:p>
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Dosimetric comparison of two-dimensional versus three-dimensional intracavitary brachytherapy in locally advanced cervical cancer
(National Library of Serbia, 2018)
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Chakalaroski, Petar
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Dimitrovska, Nadica
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Long Term Trastuzumab in Metastatic Setting of the Patients with HER2Positive Breast Cancer
(OMICS Publishing Group, 2016)
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Lazarova, Emilija
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BRCA1 and BRCA2 germline variants in breast cancer patients from the Republic of Macedonia
(Springer Science and Business Media LLC, 2018-04)
Jakimovska, Milena
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Maleva Kostovska, Ivana
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Popovska-Jankovic, Katerina
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Kubelka-Sabit, Katerina
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Karadjozov, Mitko
We aimed to establish the spectrum of BRCA1/2 mutations among the breast cancer (BC) patients from the Republic of Macedonia.

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