Faculty of Medicine
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Item type:Publication, Costs of treating serious adverse effects of drugs used for treatment of obesity: comparison of selected European countries(Informa UK Limited, 2024-11-03) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Seminal Fluid Microbiota and Male Infertility: An Emerging Frontier(Macedonian Association of Anatomists and Morphologists, 2024-10); ; ; ; Infertility is a multifaceted issue affecting millions globally, with male factors contributing to approximately 50% of cases. Traditionally, male infertility has been linked to genetic, hormonal, and environmental factors. However, emerging research highlights that disruptions or imbalances of the microbiota residing in the male reproductive tract, including the prostate, seminal vesicles, and urethra have significant implications for male reproductive health. Male urogenital system, particularly the urethra is home to a wide variety of microorganisms with rather high quantity. The composition of male genital microbiome can vary significantly between individuals and while the core microbiome is consised of a few dominant species a high variability is noted in minor species. It is predominantly composed of bacteria, with species from the genera Lactobacillus, Staphylococcus, Corynebacterium, and Propionibacterium being commonly found. Differentiating between pathogenic bacteria and the usual resident microflora is a difficulty in clinical practice, especially when it comes to male infertility. Furthermore, even though it is often benign, an imbalance in the commensal microbiota might encourage inflammation or foster an atmosphere that is favorable for pathogenic infections. Therefore, it is crucial to comprehend and maintain this equilibrium in order to create successful plans for the treatment and prevention of infertility. Traditional diagnostic approaches on male infertility focus on hormonal levels, sperm analysis, sperm culture and genetic factors, but unlike conventional culture methods which might find it difficult to distinguish between pathogenic and benign microorganisms because of genotypic and phenotypic overlaps and low pathogen presentation, developments in molecular methods for microbiota analysis, offer the possibility of more precise diagnosis and treatment of urogenital infections and imbalances. Modulating the genital microbiome could offer new treatment strategies for male infertility and related conditions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ADJUVANT TREATMENT WITH POLYPHENOLS REDUCES OXIDATIVE STRESS PARAMETERS IN IMATINIB TREATED PATIENTS WITH CHRONIC MYELOID LEUKEMIA(Serbian Redox Society, 2024-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with chronic myeloid leukemia treated with imatinib(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2024-03); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, NEPHROPROTECTIV EFFECTS OF CANDESARTAN ON DIABETIC NEPHROPATHY IN RATS(Macedonian Association of Anatomists and Morphologists, 2023); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The role of TGF-β1 in the development of diabetic nephropathy experimentally induced by Streptozotocin and the nephroprotective effects of Candesartan(Macedonian Association of Anatomists and Morphologists, 2023-12); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ASSESSMENT AND CORELATION OF OXIDATIVE STRESS BETWEEN HEALTHY ADULTS AND ADULT PATIENTS WITH CHRONIC MYELOID LEUKEMIA TREATED WITH IMATINIB(Macedonian Association of Anatomists, 2023-05-10); ; Reactive oxygen species (ROS) are oxygen-containing radicals essential for cell signaling and other vital physiological functions. However, their increased production to an excessive amount can cause alterations in the cellular redox status with consecutive disruption of various normal biological functions. Oxidative stress (OS) occurs when there is an imbalance between ROS production and antioxidant defence mechanisms. Chronic OS results in many DNA modifications, and alterations in DNA repair, leading to DNA lesions of which many can be toxic and/or mutagenic. It is proven that OS is involved in the pathogenesis of chronic myeloid leukaemia (CML), a myeloproliferative neoplasm characterized by uncontrolled proliferation of maturing and mature myeloid cells, caused by the presence of translocation t(9;22) leading to the abnormal BCR-ABL fusion protein. Historically treatment options for this disease were limited, with allogeneic stem cell transplant being the only potential curative therapy, but still with poor prognosis. Fortunately, the introduction of tyrosine kinase inhibitors (TKIs) changed dramatically the prognosis of CML patients, turning a once fatal disease, into a chronic and manageable disorder. Analysis of CML patients treated with TKIs revealed a potential correlation between toxic effects of TKIs and levels of ROS. Even though the innovation of this therapy has significantly improved the life expectancy CML patients, still, in some cases, this treatment becomes ineffective. In order to clarify these observations, we measured and correlated the level of oxidative stress between healthy individuals and patients with chronic myeloid leukemia (CML) treated with first generation tyrosine kinase inhibitors (TKIs).The two markers of oxidative stress, d-ROMs and OSI were significantly higher in the group of patients with CML compared to healthy subjects. No statistically significant differences were observed between CML patients and healthy subjects regarding the oxidative stress marker PAT. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Treatment of patients with severe aplastic anaemia with allogeneic stem cell transplantation - single centre experience(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2022-04); ; ; Aplastic anemia is a rare hematological syndrome caused by bone marrow failure and pancytopenia. It can be either inherited or acquired, the second one being more common. A variety of trigger factors have been implicated in the etiology of acquired aplastic anemia. However, in around 70% of the cases, the reason remains unknown. The two first line treatment options with competitive rate of success are immunosuppressive therapy (IST) and allogeneic stem cell transplantation (SCT). In this retrospective study we present our experience in the treatment of thirteen patients with severe acquired aplastic anemia. Six of the patients mentioned underwent matched unrelated (MUD) SCT and had all been previously treated with IST, except for one patient. The remaining seven patients included in our study underwent matched related SCT, without previous IST. Conditioning regimen, graft versus host prophylaxis, veno occlusive disease prophylaxis, antimicrobial prophylaxis and treatment, source of stem cells, as well as blood counts were taken into account, within a 7 year follow up period on average. Our findings revealed an overall survival rate of 92%. Three cases of graft versus host disease were observed, two within the MUD SCT group of patients (33%) and one within the matched related SCT group (17%). Faster engraftment was reached in patients treated with matched related SCT. One patient demanded a second allogeneic SCT. Comparable to other findings in literature, our study corroborated the favorable outcome of both allogeneic related and unrelated hematopoietic stem cell transplantation in the treatment of patients with severe aplastic anemia. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Current treatment options and considerations for patients with relapsed/refractory diffuse large B cell lymphoma in North Macedonia(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2021-12); ; ; ; Kocoski, BozidarAutologous stem cell transplantation (ASCT) is considered standard therapeutic approach for patients with relapsed and refractory (R/R) diffuse large B cell lymphoma (DLBCL) that are transplant eligible. For transplant ineligible patients there are few therapeutic options and novel targeted therapies and immunotherapy that are still in development. Treatment of such patients with poor prognosis is considered to be a challenge and there is constant need for new salvage treatment regimens. The aim of this study was to evaluate patients’ characteristics and treatment strategies and considerations for diffuse large B cell lymphoma in our department, and to promote new therapeutic possibilities for R/R patients with NHL DLBCL. A total of 308 patients with NHL were treated at University Clinic for hematology from 2008 until 2020 and 49% (151) of patients with NHL DLBCL were included in this study. Survival analysis of all analyzed relapsed/refractory NHL patients revealed statistically significant better survival in patients with low risk IPI score, disease stage I/II and patients with age <60 years. R CHOP was superior treatment as first line regimen and in the R/R patients, ASCT was statistically superior to other available second line treatment options. Overall survival in patients with DLBCL that achieved complete response after initial treatment was 80%. The incidence of disease relapse after initial treatment in the first 12 months was 18%. Overall survival in all treatment groups was 60% in the evaluated period of 2.5 years follow up. A total of 60% of patients with relapsed forms of NHL DLBCL were candidates for treatment with high-dose chemotherapy and ASCT. Other 40% patients were not candidates for ASCT. In conclusion we confirm the need for new treatment options for patients that relapse after ASCT and that are transplant ineligible. Patients and disease characteristics can be used to identify high-risk patients, classify once relapsed patients and define decision on further treatment - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREDICTIVE INSTRUMENT FOR ASYMPTOMATIC EARLY-STAGE CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS-SINGLE CENTRE EXPERIENCE(Macedonian Association of Anatomists, 2021-12-28); ; ; ; Stojanovska, SimonaEarly-stage patients with Chronic lymphocytic leukemia (CLL) are diagnosed without need for treatment, managed with following. The distinct course of the disease is diverse, and planing treatment is barely projected at diagnosis. The aim of the study was first-time evaluation of international prognostic score to predict time to first treatment (TFT) in patients with early stage CLL (International Prognostic Score for Early-stage CLL IPS-E). Retrospective study of asymptomatic patients with CLL at early stage of disease in a period of time from January 2011 to January 2021. The median follow-up was 60 months (1-120 months). Individual patient data from 120 treatment-naïve CLL patients with Binet A stage were analyzed to composed International Prognostic Score for Early-stage CLL and correlated with Time to treatment failure (TTF). Using IPS-E patients were distributed in three groups: low risk with 7, 5%, intermediate risk with 44 % and high risk patients 49%. Average TFS was 29, 3 months for low risk group, 28, 6 months for intermediate-risk group and 27,1 months for high-risk group. Using prognostic nomogram we calculated 5 years probability of survival for low, intermediate and high risk group: 73%, 72% and 70% respectively with projected median survival of 9, 1 year for low risk group and 9, 0 year, 8, 9 years for intermediate and high risk groups.