Faculty of Medicine

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Author: search.filters.author.Krstev, Toni

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    THE IMPACT OF NUTRITIONAL STATUS ON GROWTH AND ANTHROPOMETRIC PARAMETERS IN CHILDREN
    (Macedonian Association of Anatomists and Morphologists, 2024)
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    Evaluation of sex-specific differences of anthropometric parameters as impact of growth and nutritional status in preschool children from Macedonian nationality. The study included a total of 200 healthy 5-5.99 years-old preschool children from Macedonian nationality. Twelve anthropometric parameters were measured, defining longitudinal, circular and transversal dimensionality of the skeleton using standard technique and instruments for measurement. The following indices were selected and calculated: weight-for –age; height-for-age and BMI. Skin –folds (triceps, scapula and thigh) were also measured. Sex-specific differences for almost all anthropometric parameters were detected, but they were not significant. Boys showed higher values than girls regarding height, weight but for BMI were not significant. Values at the 50th percentile in boys were 20 kg for BW, 113.2 cm for BH and 15.94 kg/m². The values of these parameters in girls were 20 kg for BW, 115.4 cm for BH and 15.64 for kg/m² for BMI. The values for skin fold for biceps were higher in boys (10.6. ± 3.9) instead of girls (9.7 ± 3.3). The results obtained can be used for criteria for assessment and detecting deviations in growth and nutritional status in preschool children.
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    COMBINING PROSTATE HEALTH INDEX AND ampMRI DATA (MRI SPECTROSCOPY) TO MANAGE PI-RADS LESIONS AND REDUCE EXCESSIVE BIOPSY, A SINGLE CENTER STUDY
    (Macedonian Association of Anatomists and Morphologists, 2023)
    Krstev, Toni
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    Stojanoski, Ivica
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    Ilievski, Lazar
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    Tufekchioski, Nerhim
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    To evaluate the values of PHI and PI-RADS findings in the early detection and prediction of prostate cancer, as well as their application in clinical trials, especially when values of PSA are in the „ grey zone„ with negative DRE. The 100 patients, men aged 50 years or older with prostate-specific antigen 4 to 10 ng/ml („gray zone„) and normal digital rectal examinationwith suspected prostate cancer were examined, who had undergone biopsy and were divided in two groups. A group with no evidence of PCa (non PCa) and the group with PCa. The performance of PHI and mpMRI PI-RADS score was compared to predict biopsy results and, specifically, the presence of clinically significant prostate cancer (csPCa) using multiple criteria. Among 100 subjects, 21 (21.0%) were diagnosed with PC, including 13 (61.95%) with csPC (Gleason≥7). By the threshold of PHI≥36, the sensitivity, specificity, PPV, and NPV to predict PCa were 100%, 68.35%, 45.65%, and 100%, respectively. The best cut-off (PHI) was 42.8% with sensitivity 85.7% and specificity 86.1%. The area under the receiver operator characteristic curve (AUC) of combining PHI and mpMRI was greater than that of PHI alone (0.993 vs. 0.954, p=0.002) and mpMRI alone (0.993 vs. 0.976, p=0.025). Comparing the performance in the identification of clinically significant prostate cancer (csPCa), we found that PHI ≥ 73.04 and PI-RADS score ≥ 4 were able to identify csPCa (Gleason score ≥ 7 (3 + 4)) both alone and added to a base model including age, PSA, fPSA-to-tPSA ratio and prostate volume. If biopsy was restricted to patients with PI-RADS 5 as well as PI-RADS 3 or 4 and PHI≥36.0, 50% of biopsy could be avoided with one csPCa patient being missed. The analyzed correlation between PHI and PI-RADS score was statistically significant (p<0.0001). According to the value of Spearman's coefficient, R=0.748, the correlation is positive, i.e. direct, and they showed that with an increase in the value of the prostatic health index, (PHI) the PI-RADS score increases, and vice versa. The combination of PHI and mpMRI had higher accuracy for detection of csPC compared with PHI or mpMRI alone.