Faculty of Medicine

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Author: search.filters.author.Krsteska, Roza

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    Item type:Publication,
    Our preliminary experience with SPECT 99m Tc-HMPAO brain perfusion scans in diagnosis of dementia
    (2015)
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    Crcareva, Biljana
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    Zdraveska-Kocova, Marina
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    Krsteska, Roza
    ABSTRACT Introduction: Dementia is a clinical syndrome caused by a spectrum of different etiopathogenetic disorders, such as neurodegenerative, infective, expansive or other morphological processes in the brain tissue. Several studies indicate the possibility of differential diagnosis of dementia according to the findings of brain SPECT study. Aim: The objective of the paper is to present our preliminary experiences with SPECT 99mTc-HMPAO brain perfusion scintigraphy in the diagnosis of dementia. Materials and methods: 99mTc-HMPAO SPECT brain perfusion was performed on 9 patients selected after detailed neuropsychiatric investigations conducted by specialist psychiatrist. Obtained images were reconstructed with commercial software Mediso Brain SP128 and the qualitative and semiquantitative analysis of the data was carried out. Results: We found hypoperfusion defects in all evaluated patients, in most cases unilateral hypoperfusion in the left hemisphere, respectively in 56% of evaluated patients and in six out of nine, respectively in 67%, hypoperfusion of the left temporal lobe. Most common finding was parietal hypoperfusion, found in 8 patients (89%) and left mesial temporal lobe hypoperfusion, detected in 6 patients (67%). Conclusion: Findings of all the evaluated patients showed indisputable defects in perfusion which in correlation with clinical criteria give useful guidance in diagnosis of dementia. We concluded that it is necessary to continue with the prospective study of larger number of patients and with multidisciplinary approach in order to obtain relevant conclusions with statistical significance.
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    Dementia and depression in older adults: a southeast European perspective: summary of a dementia psychogeriatric symposium held in Ohrid, Macedonia, 23 May 2013
    (2014)
    Mukaetova-Ladinska, Elizabeta B
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    Krsteska, Roza
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    Tsolaki, Magda
    We present a report on the recent symposium on dementia and depression in older adults, held in Ohrid, Macedonia and discuss the urgent need for development of psychogeriatric and affiliated services in the Southeast European region. The limited epidemiological data from nine countries in this region suggest high variability of prevalence rates for mental health problems in older adults (>65 years of age). At the moment, there are over 520,000 older adults in the region living with dementia alone. The prevalence rates for dementia (%) are either similar to those of the developed countries (9-9.6% in build-up northern Greece and Albania, respectively) or substantially lower (3.6-4% in rural northern Greece and Montenegro, respectively). The latter may be due to either cultural diversity or lack of adequate medical health service provision and expertise to recognize and diagnose dementia. Indeed, there is a lack of organized specialized services for older adults with mental health problem in the region. The symposium raised the awareness of this problem in the region and called for networking between isolated individuals working in this field to improve the current situation and facilitate further development of adequate clinical services to meet the growing needs of the older adults in the countries of the Southeast Europe.