Faculty of Medicine
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Item type:Publication, Incidence and Prevalence of Vaginal Infections in Women of Reproductive Age in North Macedonia(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-07-01); In the available literature on this subject there are many studies which describe the effects of sexually transmitted infections on pregnancy and fertility of women. Because of the frequency of the infections with the atypical bacteria of the Ureaplasma Spp., Mycoplasma Spp., Chlamydia Trachomatis, as well as HPV infections in women of reproductive age, it is easy to underestimate their importance when establishing the basis of the genital health of women of reproductive age. In this prospective analysis, conducted from 2014 to 2018 in the laboratory for HPV and Molecular diagnostics at the University Clinic of Gynaecology and Obstetrics in Skopje, North Macedonia, we analysed the results of 10,387 patients of all ages, of which 973 patients were of reproductive age. A Panel analysis was also conducted (including the above-mentioned pathogens). An HPV analysis was also conducted on 643 patients in this group. Within the group of 643 patients, there was a positive result for HPV in 26.7% of them, while in 40.9% there was a positive result for one or more pathogens on the Panel analysis of bacterial pathogens. The statistical analysis of the results showed that the most frequent of all bacterial pathogens within the Macedonian population of women of reproductive age is Ureaplasma Spp, with an incidence of 33%, followed by Mycoplasma Spp., with 7.8%, while Chlamydia Trachomatis was present in 6.4% of the cases. We should highlight that a co-infection with HPV was present in 18.5% of all the patients where there was analysis of both diagnostic procedures. The analysis of the results in the patients co-infected with HPV and at least one bacterial pathogen on the Panel Analysis, showed a very high statistical correlation (p<001). - Some of the metrics are blocked by yourconsent settings
Item type:Publication, LOCAL NITRIC OXIDE SYNTHESIS IN THE VAGINA AND ITS IMPLICATION ON PREMATURE DELIVERY(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; Nitric oxide is a ubiquitous molecule involved in a range of physiologic and pathophysiologic processes, and is often at the centre of the scientific debate with its inherent complexity. Synthesised under the influence of its three isoenzymes, this molecule has been implicated in processes like inflammation, premature birth and carcinogenesis. Via comparative and experimental biochemical analysis of the cervical fluid of a group of patients with premature labour pains, using the indirect method of detection (the Griess spectrophotometric analysis), as well as analysis of the systemic inflammatory response, this study shows the association of nitric oxide with the premature births before the gestational week 34 as an independent marker for development of premature birth. It also showsthe association between the local nitric oxide synthesis in the vagina and the systemic inflammatory response and the significance of this association in the development of premature birth - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Periureteralna endometrioza - prikaz slučaja(Serbian Medical Society, 2022); ; ; Cilj rada bio je da se prikaže redak slučaj periureteralne endometrioze kod odrasle pacijentkinje, i da se naglase značaj sumnje na endometriozu urinarnog trakta i važna uloga skenera male karlice u postavljanju tačne dijagnoze ove retke bolesti. Autori prikazuju redak slučaj periureteralne endometrioze sa simptomima koji prvenstveno potiču od endometrioze jajnika. Dijagnoza periureteralne endometrioze utvrđena je na osnovu skenera male karlice i abdomena. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HETEROGENEITY OF ENDOMETRIUM – AN INCREASED RISK FACTOR FOR ENDOMETRIAL MALIGNANCY(Македонско лекарско друштво = Macedonian Medical Association, 2021-03); ; ; Introduction. The normal postmenopausal endometrium should appear thin, homogeneous and echogenic. Endometrial cancer causes the endometrium to thicken, appear heterogeneous, have irregular or poorly defined margins, and show increased color Doppler signals. Aim. To examine the correlation between endometrial echogenicity and the risk of endometrial malignancy in postmenopausal women. Methods. This was a prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics-Skopje, divided into two groups: control and examined. The coнtrol group included 40 postmenopausal patients, hospitalized and operated on due to urogenital pathology. The examined group consisted of 80 patients divided into two subgroups – a group with uterine bleeding and the other one without uterine bleeding. According to the ultrasound verified thickness of the endometrium, the two subgroups were divided according to endometrial thickness into: the first group with endometrial thick ness from 5-8 mm; the second from > 8-11mm and the third group above 11 mm. We made ultrasound examination by measuring the echogenicity of the endometrium in both groups of patients as well as in sub groups, which were also divided into other subgroups according to endometrial thickness. Results. The probability of endometrial malignancy was significantly increased by 4,938 in heterogenous endometrium. Conclusion. There are many examples of intratumor heterogeneity in endometrial malignancy, either at the morphologic or the molecular level. Attention should be paid so as not to miss minor subpopulations of tumor cells with diagnostic and prognostic relevance.