Faculty of Medicine
Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/14
Browse
2 results
Search Results
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, LOCAL NITRIC OXIDE SYNTHESIS IN THE VAGINA AND ITS IMPLICATION ON PREMATURE DELIVERY(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; Nitric oxide is a ubiquitous molecule involved in a range of physiologic and pathophysiologic processes, and is often at the centre of the scientific debate with its inherent complexity. Synthesised under the influence of its three isoenzymes, this molecule has been implicated in processes like inflammation, premature birth and carcinogenesis. Via comparative and experimental biochemical analysis of the cervical fluid of a group of patients with premature labour pains, using the indirect method of detection (the Griess spectrophotometric analysis), as well as analysis of the systemic inflammatory response, this study shows the association of nitric oxide with the premature births before the gestational week 34 as an independent marker for development of premature birth. It also showsthe association between the local nitric oxide synthesis in the vagina and the systemic inflammatory response and the significance of this association in the development of premature birth - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HETEROGENEITY OF ENDOMETRIUM – AN INCREASED RISK FACTOR FOR ENDOMETRIAL MALIGNANCY(Македонско лекарско друштво = Macedonian Medical Association, 2021-03); ; ; Introduction. The normal postmenopausal endometrium should appear thin, homogeneous and echogenic. Endometrial cancer causes the endometrium to thicken, appear heterogeneous, have irregular or poorly defined margins, and show increased color Doppler signals. Aim. To examine the correlation between endometrial echogenicity and the risk of endometrial malignancy in postmenopausal women. Methods. This was a prospective clinical study involving 120 postmenopausal patients treated at the University Clinic for Gynecology and Obstetrics-Skopje, divided into two groups: control and examined. The coнtrol group included 40 postmenopausal patients, hospitalized and operated on due to urogenital pathology. The examined group consisted of 80 patients divided into two subgroups – a group with uterine bleeding and the other one without uterine bleeding. According to the ultrasound verified thickness of the endometrium, the two subgroups were divided according to endometrial thickness into: the first group with endometrial thick ness from 5-8 mm; the second from > 8-11mm and the third group above 11 mm. We made ultrasound examination by measuring the echogenicity of the endometrium in both groups of patients as well as in sub groups, which were also divided into other subgroups according to endometrial thickness. Results. The probability of endometrial malignancy was significantly increased by 4,938 in heterogenous endometrium. Conclusion. There are many examples of intratumor heterogeneity in endometrial malignancy, either at the morphologic or the molecular level. Attention should be paid so as not to miss minor subpopulations of tumor cells with diagnostic and prognostic relevance.